Polyethyleneimine-Based Core-Shell Nanogels: A Promising siRNA Carrier for Argininosuccinate Synthetase mRNA Knockdown in HeLa Cells

Mimi, Hetti; Ho, Kin Man; Siu, Yuen Shan; Wu, Aihua; Li, Pei

doi:10.1016/j.jconrel.2011.10.035

Cited by 66 publications

(43 citation statements)

References 24 publications

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“…Cationic gelatin, where the introduction of amine residues on the carboxyl groups increases the polymer positive charge, has been successfully employed for delivery of small interfering RNA (siRNA) [38, 50], as well as intracellular DNA [51, 52]. Several agents have been used to “cationize” gelatin, such as ethylenediamine [38, 49], polyethylenimine [50, 53], and spermine [9, 54, 55]. …”

Section: Modification Of Gelatinmentioning

confidence: 99%

“…The use of PEI-modified gelatin systems bypasses this issue, improving simultaneously plasmid entrapment efficiency of pure gelatin [9]. Mimi et al implemented this strategy and reported a novel core-shell nanocarrier for siRNA delivery [50]. The presence of a gelatin core posed steric limitations to the PEI molecules in the outer shell, thus limiting PEI interaction with cell membranes [50].…”

Section: Modification Of Gelatinmentioning

confidence: 99%

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Gelatin carriers for drug and cell delivery in tissue engineering

Santoro

Tatara

Mikos

2014

Journal of Controlled Release

326

202

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The ability of gelatin to form complexes with different drugs has been investigated for controlled release applications. Gelatin parameters, such as crosslinking density and isoelectric point, have been tuned in order to optimize gelatin degradation and drug delivery kinetics. In recent years, focus has shifted away from the use of gelatin in isolation towards the modification of gelatin with functional groups and the fabrication of material composites with embedded gelatin carriers. In this review, we highlight some of the latest work being performed in these areas and comment on trends in the field. Specifically, we discuss gelatin modifications for immune system evasion, drug stabilization, and targeted delivery, as well as gelatin composite systems based on ceramics, naturally-occurring polymers, and synthetic polymers.

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Section: Modification Of Gelatinmentioning

confidence: 99%

Section: Modification Of Gelatinmentioning

confidence: 99%

Gelatin carriers for drug and cell delivery in tissue engineering

Santoro

Tatara

Mikos

2014

Journal of Controlled Release

326

202

View full text Add to dashboard Cite

show abstract

“…Our group has already synthesized a variety of PEI-based coreeshell particles and studied their formation mechanism [26e28]. We have also developed diverse applications using these coreeshell particles because of their unique chemical and physical properties such as high surface area to volume ratio, well-defined coreeshell nanostructure with tunable composition, surface functionality, and good water dispersibility [29,30].…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of gold/polymer nanocomposite particles using polymeric amine-based particles as dual reductants and templates

Tan

Lee

Chen

et al. 2015

Polymer

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“…Ethylenediamine GNPs succeeded to prolong release of luciferase siRNA correspond to those of nanospheres degradation [107]. Polyethylenimine loaded GNPs are also able to completely condense with siRNA and effectively protect siRNA against enzymatic degradation [108].Cationized GNPs are favorable phagocytized by dendritic cells (DCs) and macrophages compared to neutral or negatively charged particulate formulations [109].…”

Section: Pegylated Gnpsmentioning

confidence: 99%