Polydopamine nanostructures as biomaterials for medical applications

Kwon, Ik Soo; Bettinger, Christopher J.

doi:10.1039/c8tb02310g

Cited by 73 publications

(61 citation statements)

References 47 publications

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“…Of particular interest is polydopamine (PDA), a coating material that has many appealing characteristics such as the ability to coat most inorganic and organic materials, low toxicity, one-step deposition using a simple method, and multiple functional properties 1 – 3 . Hence, since its inception in 2007, its utilization has grown extensively in numerous fields of engineering, including biomaterials 4 , 5 , energy storage and harvesting devices 6 , photonics 7 , 8 , and medical therapeutics 9 .…”

Section: Introductionmentioning

confidence: 99%

Laser-induced graphitization of polydopamine leads to enhanced mechanical performance while preserving multifunctionality

et al. 2020

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Polydopamine (PDA) is a simple and versatile conformal coating material that has been proposed for a variety of uses; however in practice its performance is often hindered by poor mechanical properties and high roughness. Here, we show that blue-diode laser annealing dramatically improves mechanical performance and reduces roughness of PDA coatings. Laser-annealed PDA (LAPDA) was shown to be >100-fold more scratch resistant than pristine PDA and even better than hard inorganic substrates, which we attribute to partial graphitization and covalent coupling between PDA subunits during annealing. Moreover, laser annealing provides these benefits while preserving other attractive properties of PDA, as demonstrated by the superior biofouling resistance of antifouling polymer-grafted LAPDA compared to PDA modified with the same polymer. Our work suggests that laser annealing may allow the use of PDA in mechanically demanding applications previously considered inaccessible, without sacrificing the functional versatility that is so characteristic of PDA.

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Section: Introductionmentioning

confidence: 99%

Laser-induced graphitization of polydopamine leads to enhanced mechanical performance while preserving multifunctionality

et al. 2020

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“… 54 , 55 Produced by the self-polymerization of dopamine, PDA contains catechol and amine groups and presents a chemical composition analogous to that of the mussel adhesive proteins. 56 , 57 Due to its unique chemistry and the interesting assortment of reactive functional groups, this bioinspired coating can act as a compatibilizer in multiple filler/matrix systems and can be subsequently functionalized. 54 , 58 PDA has been proven to be effective in improving the filler–matrix adhesion with several types of fillers (e.g., nanoclays, 59 carbon nanotubes 60 ), but a very limited number of articles can be found on the application of this coating procedure to formaldehyde-based resins and, to the best of the authors’ knowledge, no articles have been published on the coating of PCM microcapsules with PDA.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Polydopamine Coating as an Adhesion Enhancer Between Paraffin Microcapsules and an Epoxy Matrix

et al. 2020

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Microencapsulated phase change materials (PCMs) are attracting increasing attention as functional fillers in polymer matrices, to produce smart thermoregulating composites for applications in thermal energy storage (TES) and thermal management. In a polymer composite, the filler–matrix interfacial adhesion plays a fundamental role in the thermomechanical properties. Hence, this work aims to modify the surface of commercial PCM microcapsules through the formation of a layer of polydopamine (PDA), a bioinspired polymer that is emerging as a powerful tool to functionalize chemically inert surfaces due to its versatility and great adhesive potential in many different materials. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) evidenced that after PDA coating, the surface roughness increased from 9 to 86 nm, which is beneficial, as it allows a further increase in the interfacial interaction by mechanical interlocking. Spectroscopic techniques allowed investigating the surface chemistry and identifying reactive functional groups of the PDA layer and highlighted that, unlike the uncoated microcapsules, the PDA layer is able to react with oxirane groups, thereby forming a covalent bond with the epoxy matrix. Hot-stage optical microscopy and differential scanning calorimetry (DSC) highlighted that the PDA modification does not hinder the melting/crystallization process of the paraffinic core. Finally, SEM micrographs of the cryofracture surface of epoxy composites containing neat or PDA-modified microcapsules clearly evidenced improved adhesion between the capsule shell and the epoxy matrix. These results showed that PDA is a suitable coating material with considerable potential for increasing the interfacial adhesion between an epoxy matrix and polymer microcapsules with low surface reactivity. This is remarkably important not only for this specific application but also for other classes of composite materials. Future studies will investigate how the deposition parameters affect the morphology, roughness, and thickness of the PDA layer and how the layer properties influence the capsule–matrix adhesion.

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“…We consistently found modest, yet statistically significant, reductions in cell numbers for each of the PDA-functionalised TCP wells compared to untreated controls ( Figure 1A). The reduction in cell number was approximately 11% (p = 0.01) for PDA films formed over 24 h. A further reduction at around 16% (p < 0.001) occurred for cells exposed to PDA films generated over 48 and 72 h. Extended DHC exposure times generate thick PDA films with greater roughness [27], a feature that can have a negative effect on cell attachment and growth [28]. We subsequently found that TCP wells treated for two hours with DHC resulted in the development of PDA films that were completely compatible with MG63 viability ( Figure 1B).…”

Section: Short-term Development Of Pda Films Are Compatible With Ostementioning

confidence: 90%

Polydopamine-Lysophosphatidate-Functionalised Titanium: A Novel Hybrid Surface Finish for Bone Regenerative Applications

et al. 2020

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Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the United Kingdom alone, it is estimated that £135m is spent annually on revision arthroplasties. Enhancing the longevity of titanium implants will help reduce the incidence and overall cost of failed devices. In realising the development of a superior titanium (Ti) technology, we took inspiration from the growing interest in reactive polydopamine thin films for biomaterial surface functionalisations. Adopting a “one-pot” approach, we exposed medical-grade titanium to a mildly alkaline solution of dopamine hydrochloride (DHC) supplemented with (3S)1-fluoro-3-hydroxy-4-(oleoyloxy)butyl-1-phosphonate (FHBP), a phosphatase-resistant analogue of lysophosphatidic acid (LPA). Importantly, LPA and selected LPA analogues like FHBP synergistically cooperate with calcitriol to promote human osteoblast formation and maturation. Herein, we provide evidence that simply immersing Ti in aqueous solutions of DHC-FHBP afforded a surface that was superior to FHBP-Ti at enhancing osteoblast maturation. The facile step we have taken to modify Ti and the biological performance of the final surface finish are appealing properties that may attract the attention of implant manufacturers in the future.

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Polydopamine nanostructures as biomaterials for medical applications

Abstract: Recent advances in polydopamine synthesis are described with a particular focus on biomedical applications. Prospects and future challenges for the application of polydopamine as a biomaterial are also described.

Cited by 73 publications

References 47 publications

Laser-induced graphitization of polydopamine leads to enhanced mechanical performance while preserving multifunctionality

Laser-induced graphitization of polydopamine leads to enhanced mechanical performance while preserving multifunctionality

Bioinspired Polydopamine Coating as an Adhesion Enhancer Between Paraffin Microcapsules and an Epoxy Matrix

Polydopamine-Lysophosphatidate-Functionalised Titanium: A Novel Hybrid Surface Finish for Bone Regenerative Applications

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