Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites

Pandey, Nikhil; Soto-Garcia, Luis; Yaman, Serkan; Kuriakose, Aneetta E.; Rivera, Andres Urias; Jones, Valinda; Liao, Jun; Nguyen, Kytai T.; Hong, Yi

doi:10.1016/j.msec.2021.112589

Cited by 23 publications

(17 citation statements)

References 104 publications

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“…The advantage of using PDA is its ability to chemically interact with proteins and biological molecules that contain thiols, amine, hydroxyl, among other nucleophilic groups by Michael addition and Schiff base reaction . It has also been reported that the mussel-inspired PDA is an excellent candidate for tissue attachment . Therefore, we treated GelMA-nSi cryogel with polydopamine to improve the cryogels’ bioadhesivity.…”

Section: Resultsmentioning

confidence: 99%

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Nanoparticle-Reinforced Tough Hydrogel as a Versatile Platform for Pharmaceutical Drug Delivery: Preparation and in Vitro Characterization

et al. 2022

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Natural polymer-based hydrogels are excellent for encapsulating hydrophilic drugs, but they are mechanically weak and degrade easily. In this communication, we exploit the electrostatic interaction between nanosilicates (nSi) and gelatin methacrylate (GelMA) to form a mechanically tough nanocomposite hydrogel for pharmaceutical drug delivery. These hydrogels, prepared at subzero temperatures to form cryogels, displayed macroporous structures, which favors cell infiltration. The designed tough cryogel also showed a slower rate of degradation. Furthermore, we encapsulated the small molecule metformin and sustained the drug release under physiological conditions. Cryogel-loaded metformin reduced the effect of endothelial cell injury caused by nutrient deprivation in vitro. Finally, we hypothesize that this versatile nanocomposite material will find use in diverse biomedical applications.

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Section: Resultsmentioning

confidence: 99%

“…54 It has also been reported that the mussel-inspired PDA is an excellent candidate for tissue attachment. 55 Therefore, we treated GelMA-nSi cryogel with polydopamine to improve the cryogels' bioadhesivity. Figure 4C displays a schematic of PDA-treated cryogel attached to tissue.…”

Section: Drug Release and In Vitromentioning

confidence: 99%

Nanoparticle-Reinforced Tough Hydrogel as a Versatile Platform for Pharmaceutical Drug Delivery: Preparation and in Vitro Characterization

et al. 2022

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“…Due to its rich content of reactive functional groups, PDA not only has unique adhesion properties but also superior hydrophilic properties. 28–30 It has been shown that nanoclay can induce the oxidation of dopamine to form PDA-clay nanosheets rich in catechol groups, which contributes to the uniform distribution of nanoclay in the polymer network and further enhances mechanical and adhesion properties. 16 Given this, we envisioned a new composite coating by embedding PDA-clay nano layers into MAO active coating, so that this composite coating can achieve both adhesion and osteogenesis effects.…”

Section: Discussionmentioning

confidence: 99%

Multidynamic Osteogenic Differentiation by Effective Polydopamine Micro-Arc Oxide Manipulations

Zhou¹,

Wang²,

Wang³

et al. 2022

IJN

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Introduction The nanostructural modification of the oral implant surface can effectively mimic the morphology of natural bone tissue, allowing osteoblasts to achieve both proliferation and differentiation capabilities at the bone interface of the dental implant. To improve the osteoinductive activity on the surface of titanium implants for rapid osseointegration, we prepared a novel composite coating (MAO-PDA-NC) by micro-arc oxidation technique and immersion method and evaluated the proliferation, adhesion, and osteogenic differentiation of osteoblasts on this coating. Methods The coatings were prepared by micro-arc oxidation (MAO) technique and immersion method, and characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) for different coatings; the loading of PDA was examined using Fourier transform infrared spectroscopy (FTIR); the ion release capacity of the coatings was determined by inductively coupled plasma emission spectrometry (ICP-OES); the interfacial bonding of the coatings was examined using nanoscratch experiment strength. The cytotoxicity of the coating was examined by live/dead staining kit; cell proliferation viability was examined by CCK-8 kit; adhesion and osteogenic effect of the coating were examined by immunofluorescence staining and RT-PCR; osteogenic differentiation was examined by alkaline phosphatase staining. Results The surface morphology of titanium implants was modified by micro-arc oxidation technology, and a new MAO-PDA-NC composite coating was successfully prepared. The results showed that the MAO-PDA-NC coating not only optimized the physical and chemical properties of the titanium implant surface but also significantly stimulated the biological properties of osteoblast adhesion, proliferation, and osteogenic differentiation on the coating surface. Conclusion These results show that MAO-PDA-NC composite coating can significantly improve the surface properties of titanium implants and achieve a stable bond between implant and bone tissue, thus accelerating early osseointegration.

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“…Besides, cysteine contributes to the presentation of the thiol group, but its concentration is generally low. Among these groups, primary amines are the most extensively utilized ones in the adhesive strategy since they are abundant and chemically reactive 19,27,28 . Additional constituents of the ECM can be a target as well.…”

Section: Design Requirements For the Adhesivesmentioning

confidence: 99%

“…primary amines are the most extensively utilized ones in the adhesive strategy since they are abundant and chemically reactive. 19,27,28 Additional constituents of the ECM can be a target as well. For instance, fatty acids, terminated with carboxylic acids, can allow firm adhesion to the tissue.…”

Section: Highlightsmentioning

confidence: 99%

Tissue adhesives for wound closure

et al. 2023

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Tissue adhesives have raised much attention from scientists in recent years.They have been extensively utilized in various medical fields, such as wound closure, due to the advantages of being simple, time-saving, and avoiding the problems and complications associated with surgical sutures. Besides, the tissue adhesives can absorb wound exudates and promote tissue repair. The rapid evolution in the field of tissue adhesives has resulted in the development of various adhesives with excellent mechanical properties and superior functions. However, many challenges still restrict their use in numerous clinical applications. In this paper, we present an up-to-date review of tissue adhesives for wound closure. We mainly discussed the fundamental design requirements for the adhesives, the fabrication of tissue adhesives, and the application of tissue adhesives on skin healing, corneal patch, and gastrointestinal tissues. We then highlighted the current challenges and unmet needs and delineated potential new clinical development directions for future adhesives. The progress in tissue adhesives will provide novel approaches for wound management and has the potential to supply effective treatments for a variety of medical applications.

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Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites

Cited by 23 publications

References 104 publications

Nanoparticle-Reinforced Tough Hydrogel as a Versatile Platform for Pharmaceutical Drug Delivery: Preparation and in Vitro Characterization

Nanoparticle-Reinforced Tough Hydrogel as a Versatile Platform for Pharmaceutical Drug Delivery: Preparation and in Vitro Characterization

Multidynamic Osteogenic Differentiation by Effective Polydopamine Micro-Arc Oxide Manipulations

Tissue adhesives for wound closure

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