Tissue adhesives for wound closure

Abstract

Tissue adhesives have raised much attention from scientists in recent years.They have been extensively utilized in various medical fields, such as wound closure, due to the advantages of being simple, time-saving, and avoiding the problems and complications associated with surgical sutures. Besides, the tissue adhesives can absorb wound exudates and promote tissue repair. The rapid evolution in the field of tissue adhesives has resulted in the development of various adhesives with excellent mechanical properties and superior functions. However, many challenges still restrict their use in numerous clinical applications. In this paper, we present an up-to-date review of tissue adhesives for wound closure. We mainly discussed the fundamental design requirements for the adhesives, the fabrication of tissue adhesives, and the application of tissue adhesives on skin healing, corneal patch, and gastrointestinal tissues. We then highlighted the current challenges and unmet needs and delineated potential new clinical development directions for future adhesives. The progress in tissue adhesives will provide novel approaches for wound management and has the potential to supply effective treatments for a variety of medical applications.

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

“…Among them, microfluidics is a technology that can precisely modulate the fluid on a microscale. [89][90][91][92][93][94][95][96][97][98][99][100] Therefore, it can be used as a reliable method to generate droplets or fibers with tunable and uniform sizes. [62,[101][102][103][104][105][106][107][108] For example, Zhang et al designed a microfluidic chip whose inner and outer phases were the colloidal suspension and silicon oil, respectively.…”

Functional adhesive hydrogels for biological interfaces

“…An ideal hydrogel adhesive for wound dressings may also need to be reusable, cleanable, and simple to remove without causing further harm. 31 Adhesive hydrogels must also possess other functionalities such as self-healing, electrical conductivity, antiswelling, and stimulus responsiveness in order to be employed effectively in applications such as bone regeneration, nerve stimulation, controllable drug release, and other bio-interface applications. [32][33][34][35] In this review, we provide an overview of recent advances in multifunctional adhesive hydrogels for biointerfaces, with a focus on bioelectronics and tissue engineering applications (Figure 1).…”

“…In this scenario, it also needs to have functions such as antibacterial, anti‐oxidation, thermal insulation, and comfortable softness. An ideal hydrogel adhesive for wound dressings may also need to be reusable, cleanable, and simple to remove without causing further harm 31 . Adhesive hydrogels must also possess other functionalities such as self‐healing, electrical conductivity, anti‐swelling, and stimulus responsiveness in order to be employed effectively in applications such as bone regeneration, nerve stimulation, controllable drug release, and other bio‐interface applications 32–35 …”

Bioinspired Asymmetric Double-Layer Dressings for Stepwise Treatment of Hemorrhagic Wounds

“…30−32 Although these elements have been used in different dressings, in terms of the management of hemorrhagic wounds, 33,34 current dressings are still lacking to meet the demands of coordinated hemostasis and angiogenesis during the whole stages of wound healing. 35,36 In this paper, our design of the double-layer BSP-PNS@ CMCS dressings along with the stepwise treatment strategy is expected for the advanced management of hemorrhagic wounds. The desired dressing (BSP-PNS@CMCS) with natural skin-mimicking asymmetric double-layer structures was fabricated via a two-step approach of lyophilizing BSP and PNS-laden CMCS hydrogels.…”

“…Such dressing (BSP-PNS@CMCS) is designed with an inner loose layer of Bletilla striata polysaccharide (BSP) sponges for adhering and retaining the blood cells via those loose pore-channels during the initial bleeding period and an outer dense layer of carboxymethyl chitosan (CMCS) loaded with panax notoginseng saponines (PNS) for promoting angiogenesis and defensing outside pathogenic microorganisms during subsequent tissue reconstruction period. BSP has been widely used for the development of advanced hemostatic materials and wound dressings, because it could accelerate coagulation by shortening the activation time of coagulation-related enzymes and increasing fibrinogen contents. , By contrast, PNS, the main constituent of panax notoginseng (Sanqi), has been employed in the design of microspheres/scaffolds for wound healing due to its intrinsic proangiogenic effects and tissue regenerative activity. , Additionally, CMCS, known as a carboxymethylated derivate of chitosan (CS), can bind and interact with the negatively charged bacterial cell membranes, exhibiting enhanced antibacterial property in various wound managements. − Although these elements have been used in different dressings, in terms of the management of hemorrhagic wounds, , current dressings are still lacking to meet the demands of coordinated hemostasis and angiogenesis during the whole stages of wound healing. , …”