Functional adhesive hydrogels for biological interfaces

Abstract

Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.

Nanofiber Hydrogel Drug Delivery System for Prevention of Postsurgical Intestinal Adhesion

“…Ideal physical barriers should be biocompatible and biodegradable, have sufficient mechanical strength, easily attach to the wound, and prevent cell penetration without restricting nutrient flow. This can be achieved by using dense poly porous materials with pore sizes smaller than the diameter of a eukaryoyic (10–100 μm). − Due to their dual function as barriers and drug transporters, biomaterials have received considerable attention in preventing PIAs. , Biomaterials engineered with micro- or nanosized structures exhibit outstanding performance, possess desirable properties, and meet the demands of clinical antiadhesive barriers. , Hydrogels, , nanofibers, sponges, − microparticles, , and cast films have been used as physical barriers frequently. Compared to sponges, microparticles, and cast films, nanofibers and hydrogels are widely used due to their ease of forming a two-dimensional membrane and better physical performance.…”