Polycystic Ovary Syndrome (PCOS) and Fertility

Barbosa, Guilherme Oliveira; Sá, Larissa Bianca Paiva Cunha de; Rocha, Denise Rosso Tenório Wanderley; Arbex, Alberto Krayyem

doi:10.4236/ojemd.2016.61008

Cited by 26 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Barbosa G et al in mentioned in their study that majority of patients with PCOS 80% presents with oligomenorrhea and 40% with amenorrhea. 8 In present study, 62% in primary infertility group and 91% in secondary infertility group had abnormal DHL findings. Table 8 shows comparing to the other studies, the prevalence of abnormal findings by DHL is comparable in primary infertility but differs in secondary infertility as in our study the secondary infertility patients were less in number.…”

Section: Discussionsupporting

confidence: 50%

Role of hysterolaparoscopy in the evaluation of female infertility in a tertiary care centre

Parihar

Gowri

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Infertility is one of the most important and underappreciated reproductive health problems in developing countries. Inability to conceive bears a social stigma which causes societal repercussion and personal suffering. The advent of hysterolaparoscopy have redefined the evaluation and treatment of infertile women. Study aimed to assess the role of hysterolaparoscopy in the evaluation of female infertility.Methods: This prospective observational study was done in the department of obstetrics and gynaecology, Gandhi Medical College, Sultania Zanana Hospital, Bhopal, during the period between 1st December 2016 to 30th November 2017. 104 infertile patients either with primary or secondary infertility were included after thorough evaluation.Results: Out of 104 infertile patients, 82(78.8%) women had primary infertility and rest 22(21.1%) women had secondary infertility. In primary infertility group, most common laparoscopic finding was PCOD in 24(29%) women and in secondary infertility group, tubal blockage was seen in 9(40%) women. The most common pathology seen in hysteroscopy was submucous fibroid in 6(7.3%) women with primary infertility, whereas in secondary infertility group, synechiae was found in 2(9%) patients and septum was seen in 1(4.5%) patient. Out of 104 patients, 33 (31.7%) patients underwent various interventions. The most common intervention was ovarian drilling for PCOS in 21(63.3%) patients followed by hysteroscopic cannulation in 5(15.5%) patients.Conclusions: Hysterolaparoscopy is a very useful tool that can detect various structural abnormalities in multiple sites like uterus, tubes, ovaries and peritoneal cavity in the same sitting. When done by experienced hands and proper selection of patients, hysterolaparoscopy can be considered as a definitive investigative procedure for evaluation of female infertility.

show abstract

Section: Discussionsupporting

confidence: 50%

Role of hysterolaparoscopy in the evaluation of female infertility in a tertiary care centre

Parihar

Gowri

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…PCOS is the most prevalent endocrinopathy of reproductive-aged women. However, infertility occurs in about 10–20% of patients with PCOS 45,46 . In our study, there is a potential selection bias since the study only included infertile patients with or without PCOS, which might be a surrogate for the severity/chronicity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome

Peng

Feng

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fertilization (IVF) in infertile women with or without PCOS. The levels of cluster of differentiation 25 (CD25), CD69, programmed death 1 (PD-1), interferon-γ (IFN-γ), interleukin 17A (IL-17A) and IL-10 in T lymphocytes were determined by flow cytometry. Our results showed that the percentage of FF CD8 + T cells was significantly decreased in infertile patients with PCOS ( P < 0.05). Furthermore, the levels of CD69 and IFN-γ were significantly decreased and the level of PD-1 was increased in both CD4 + and CD8 + T cells from infertile patients with PCOS ( P < 0.05). Moreover, the expression of PD-1 on CD4 + or CD8 + T cells was positively correlated with the estradiol (E2) levels in the serum and reversely correlated with the expression of IFN-γ in CD4 + or CD8 + T cells in infertile patients with PCOS. These results suggested that T cell dysfunction may be involved in the pathogenesis of PCOS.

show abstract

“…[3] It causes infertility primarily due to ovulatory dysfunction. [4] However, the underlying mechanisms of PCOS-associated infertility remain unclear. Many factors may lead to PCOS-associated infertility, and an impaired endometrial implantation could be responsible for this situation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of endometrial receptivity by measuring HOXA-10, HOXA-11, and leukemia inhibitory factor expression in patients with polycystic ovary syndrome

Kara

Özcan

Aran

et al. 2019

Gynecol Minim Invasive Ther

View full text Add to dashboard Cite

Context:Polycystic ovary syndrome (PCOS) is an important cause of infertility. In women with PCOS have increased rate of spontaneous abortion and reduced rate of conception. HOXA–10 and HOXA–11 are proteinous products of homeobox gene group and play an important role during implantation.Aims:The aim of this study was to evaluate endometrial receptivity by measuring HOXA–10, HOXA–11, and leukemia inhibitory factor (LIF) gene expressions in women with PCOS.Settings and Design:A tertiary referral center.Materials and Methods:This study was conducted on reproductive age women with abnormal uterine bleeding without sonographically proven anatomical reason. Endometrial sampling procedures were done in proliferative phase using low-pressure endometrial suction device to exclude endometrial pathology. HOXA–10, HOXA–11, and LIF gene expressions were measured from endometrial sampling material. Blood sample was taken to measure serum estradiol level on the day of endometrial sampling.Statistical Analysis Used:Statistical analysis was performed using SPSS software version 17 (SPSS Inc., Chicago, IL, USA). Mann–Whitney U-test was used to compare the variables.Results:A total of 53 patients were included in this study. Study group consisted of 33 patients with PCOS. Gene expressions of HOXA–10, HOXA–11, and LIF were significantly lower in patients with PCOS (P < 0.05).Conclusions:This study results showed that in patients with PCOS have decreased gene expression of HOXA-10, HOXA-11, and LIF which might contribute PCOS-related infertility.

show abstract

Polycystic Ovary Syndrome (PCOS) and Fertility

Cited by 26 publications

References 29 publications

Role of hysterolaparoscopy in the evaluation of female infertility in a tertiary care centre

Role of hysterolaparoscopy in the evaluation of female infertility in a tertiary care centre

Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome

Evaluation of endometrial receptivity by measuring HOXA-10, HOXA-11, and leukemia inhibitory factor expression in patients with polycystic ovary syndrome

Contact Info

Product

Resources

About