Polycaprolactone-gelatin nanofibers incorporated with dual antibiotic-loaded carboxyl-modified silica nanoparticles

Gounani, Zahra; Pourianejad, Sajedeh; Asadollahi, Mohammad Ali; Rosenholm, Jessica M.; Arpanaei, Ayyoob

doi:10.1007/s10853-020-05253-7

Cited by 18 publications

(11 citation statements)

References 58 publications

(77 reference statements)

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“…PCL/GEL NFs with excellent biocompatibility and appropriate mechanical and chemo-physical properties has been successfully exploited for controlled drug delivery approaches and various tissue engineering purposes. 41,42 The findings of drug release agreed with the results of recent studies, showing that MSNs could warrant a slow and partial discharge with a reduced initial drug release rate of small therapeutic molecules from NFs. 19,38 A combination of initial burst release and late sustained release was observed in CUR/CUR@MSNs-NFs.…”

Section: Discussionsupporting

confidence: 87%

“…In this work, PCL/GEL hybrid polymer was utilized to fabricate the CUR/CUR@MSNs‐loaded electrospun nanofibrous scaffolds. PCL/GEL NFs with excellent biocompatibility and appropriate mechanical and chemo‐physical properties has been successfully exploited for controlled drug delivery approaches and various tissue engineering purposes 41,42 …”

Section: Discussionmentioning

confidence: 99%

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Dual drug release mechanisms through mesoporous silica nanoparticle/electrospun nanofiber for enhanced anticancer efficiency of curcumin

Sadeghi-Soureh

et al. 2021

J Biomedical Materials Res

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Electrospun nanofibers (NFs)‐based drug delivery approaches are of particular interest as a hopeful implantable nanoplatform for localized cancer therapy and treating tissue defect after resection, allowing the on‐site drug delivery with minimal side effect to healthy cells. To maintain therapeutic concentrations of anticancer molecules for a relatively long time through a combination of burst and sustained drug release mechanisms, a hybrid of polycaprolactone and gelatin (PCL/GEL) was used for co‐encapsulation of free curcumin (CUR) and CUR‐loaded mesoporous silica nanoparticles (CUR@MSNs) via electrospinning, resulting in a novel drug‐loaded nanofibrous scaffold, CUR/CUR@MSNs‐NFs. The as‐prepared MSNs and composite NFs were characterized via TGA, FTIR, FE‐SEM, TEM, and BET. In vitro release profile of CUR from CUR/CUR@MSNs‐NFs was examined, and the in vitro antitumor efficacy against MDA‐MB‐231 breast cancer cells was also evaluated through MTT, scratch assay, DAPI staining, and real‐time PCR. The results disclosed that the smooth, bead‐free, and randomly oriented CUR/CUR@MSNs‐NFs displayed a combination of initial rapid discharge and sustained release for CUR, which led to higher cytotoxicity, lower migration as well as a more pronounced effect on apoptosis induction than CUR‐NFs and CUR@MSNs‐NFs. The present study illustrated that the dual drug release mechanisms through MSN/NF‐mediated drug delivery systems might have a highly hopeful application as a localized implantable scaffold for potential postoperative breast cancer therapy.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Dual drug release mechanisms through mesoporous silica nanoparticle/electrospun nanofiber for enhanced anticancer efficiency of curcumin

Sadeghi-Soureh

et al. 2021

J Biomedical Materials Res

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“… 48 Also, Gounani et al prepared PCL NF with a fiber diameter range between 156 and 179 nm, considered to be in the same range of the prepared fibers in this study. 49 …”

Section: Discussionmentioning

confidence: 99%

In Vitro Biological Evaluation of a Fabricated Polycaprolactone/Pomegranate Electrospun Scaffold for Bone Regeneration

et al. 2021

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Different scaffold biomaterials are being investigated as a solution for bone loss due to disease or trauma. The aim of this study is the fabrication, characterization, and in vitro biological evaluation of a novel polycaprolactone (PCL) nanoscaffold incorporating pomegranate peel extract (PG) for bone regeneration. Using electrospinning, three groups of scaffolds were prepared: the control group PCL and two groups of PCL with PG concentrations (11 and 18 weight %). The antioxidant activity and the total phenolic content (TPC) of the fabricated nanoscaffolds were evaluated, in addition to the porosity and degradation measurement. Cultured osteoblasts derived from rabbit bone marrow mesenchymal stem cells were used for the assessment of cell proliferation and attachment on the scaffold’s surface. Scaffolds’ characterization showed uniform nanofibers (NFs) with a fiber diameter range of 149–168 nm. Meanwhile, higher antioxidant activity and TPC of the PG groups were detected. Furthermore, total porosities of 59 and 62% were determined for the PCL–PG scaffolds. An increased degradation rate and significant improvement in cell proliferation and cell attachment were revealed for the PCL–PG fabricated scaffolds. Such incorporation of natural food waste, PG, in PCL NFs offered novel PCL–PG scaffolds as a promising candidate for bone regeneration applications.

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“…Other recent examples include fibers electrospun from poly(vinyl pyrrolidone), 101 polystyrene (PS), 105 PLA, 106 and PLGA. 107 The SyPs for electrospinning can be surface treated with laminin, 108 FN, 109 gelatin, 110 and other proteins to improve cell adhesion or they can be chemicaly functionalization with cell adhesion motifs. For example, Amores-de Sousa et al fabricated highly aligned PCL electrospun nanofibers functionalized with a peptide that contained RGD motifs (GRGDSP).…”

Section: Materials Advancesmentioning

confidence: 99%

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

et al. 2021

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Polycaprolactone-gelatin nanofibers incorporated with dual antibiotic-loaded carboxyl-modified silica nanoparticles

Abstract: Polycaprolactone-gelatin nanofibers incorporated with dual antibiotic-loaded carboxyl-modified silica nanoparticles.

Cited by 18 publications

References 58 publications

Dual drug release mechanisms through mesoporous silica nanoparticle/electrospun nanofiber for enhanced anticancer efficiency of curcumin

Dual drug release mechanisms through mesoporous silica nanoparticle/electrospun nanofiber for enhanced anticancer efficiency of curcumin

In Vitro Biological Evaluation of a Fabricated Polycaprolactone/Pomegranate Electrospun Scaffold for Bone Regeneration

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

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