Polyacetylene aus Pimpinella‐Arten

Schulte, K. E.; Rüċker, G.; Backe, W.

doi:10.1002/ardp.19703031109

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…The seeds of Pimpinella anisum contain anethole (Chandler & Hawkes, 1984), pseudoisoeugenol (Reichling et al, 1995), coumarins, scopoletin, umbelliferon, estrols (Burkhardt et al, 1986), terpene hydrocarbons (Kartnig et al, 1975), polyenes and polyactylenes (Schulte et al, 1970).…”

Section: Introductionmentioning

confidence: 98%

Possible Mechanism for the Relaxant Effect ofPimpinella anisum. on Guinea Pig Tracheal Chains

Boskabady

Ramazani-Assari

2005

Pharmaceutical Biology

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Pimpinella anisum L. is a grassy plant that is believed to have several therapeutic effects including antiasthmatic uses. In a previous study, the relaxant (bronchodilatory) effect of this plant on isolated guinea pig tracheal chains was demonstrated. To study mechanisms responsible for this effect, the inhibitory effect of this plant on contracted tracheal chains of guinea pig was evaluated in the current study. The relaxant effects of aqueous and ethanol extracts and essential oil from P. anisum compared to negative controls (saline for aqueous extract and essential oil and ethanol for ethanol extract) and positive control (diltiazem) were examined on precontracted isolated tracheal chains of the guinea pig by 10 mM methacholine (group 1) and 60 mM KCl (group 2, n ¼ 7 for each group). In group 1 experiments, diltiazem, both extracts, and essential oil from P. anisum showed significant relaxant effect on methacholine-induced contraction of tracheal chains compared to those of negative controls (p < 0.05 to p < 0.001). In addition, the effects of extracts were significantly greater than that of diltiazem (for aqueous and ethanol extracts p < 0.05 and p < 0.01, respectively). However, in group 2 experiments, only diltiazem and ethanol extract showed significant relaxant effects on KCl-induced contraction of tracheal chains (p < 0.05 for ethanol extract and p < 0.001 for diltiazem). Relaxant effects of extracts and essential oil obtained in group 2 experiments were significantly lower than those of group 1 (p < 0.05 to p < 0.001). These results confirm the bronchodilatory effects of extracts and essential oil from P. anisum. However, with regard to the effect of KCl on calcium channels, the results indicated that inhibitory effect of only ethanol extract from P. anisum on calcium channels may contribute to its relaxant (bronchodilatory) effects on guinea pig tracheal chains. In addition, the results suggest a potassium channel opening effect for this plant, which may contribute on its relaxant effect on tracheal chains of guinea pig.

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Section: Introductionmentioning

confidence: 98%

Possible Mechanism for the Relaxant Effect ofPimpinella anisum. on Guinea Pig Tracheal Chains

Boskabady

Ramazani-Assari

2005

Pharmaceutical Biology

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“…Essential oils from this genus are common and have been well studied in some species. Besides essential oils, some bioactive compounds from this genus include flavonoids,[ 1 , 2 ] phenols, phenylpropanoids,[ 2 ] saponins,[ 2 ] furanochromones,[ 3 ] furanocoumarins,[ 3 , 4 ] coumarins,[ 5 ] polyacetylenes,[ 6 ] steroids, and diterpens. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Pimpinella pruatjan Molk: LC-MS/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts

Timotius

Rahayu

Nurcahyanti

2023

Journal of Pharmacy and Bioallied Sciences

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Pimpinella pruatjan Molk is native to Java and well known as aphrodisiac in traditional medicine. A water-boiled extract of the plant has been used in the treatment of erectile dysfunction (ED). No study has been found on the phytochemical constituents and identification of corresponding biological activities in water and polar extract. This study is aimed to identify phytoconstituents of a decoction and ethanol extract from the aerial parts of P. pruatjan Molk. Liquid chromatography-tandem mass spectroscopy (LC-MS/MS) was used to analyze and predict the bioactive compounds in both extracts. LC-MS/MS revealed both extracts contained two important compounds: Luteolin-7-O-β-D glucopyranoside and Undulatoside A. Luteolin and Luteolin glucoside are also found in P.anisum L. Lutein 7-O glucoside was found in water extract, while more bioactive compounds, including populnin, 3,5-O-dicaffeoylquinic acid, quercetin-3’- O glucoside, methylophiopogononeone-A, kaempferol-7-O-α-L-arabinofuranoside, and 7-hydroxy-3,5,6,3’,4’- pentamethoxyflavone, were found in ethanol extract. Accumulation of flavonoids, phenols, phenylpropanoids, alkaloids, and furanochromone in low quantities was observed in both extracts. This is the first report providing evidence justifying its use as a traditional medicine. Further investigation into the pharmacology mechanism of action is required.

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Acetylenes and Psoralens

Christensen¹,

Brandt²

2006

Plant Secondary Metabolites

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Polyacetylene aus Pimpinella‐Arten

Cited by 13 publications

References 12 publications

Possible Mechanism for the Relaxant Effect ofPimpinella anisum. on Guinea Pig Tracheal Chains

Possible Mechanism for the Relaxant Effect ofPimpinella anisum. on Guinea Pig Tracheal Chains

Pimpinella pruatjan Molk: LC-MS/MS-QTFT Analysis of Bioactive Compounds from Decoction and Ethanol Extract of Aerial Parts

Acetylenes and Psoralens

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