Possible Mechanism for the Relaxant Effect of<i>Pimpinella anisum</i>. on Guinea Pig Tracheal Chains

Boskabady, Mohammad Hossein; Ramazani-Assari, M

doi:10.1080/13880200490902527

Cited by 10 publications

(13 citation statements)

References 16 publications

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“…(Boskabady, Khatami, 2003) H. canadensis EE 0.1, 0.5, 0.75, 1, 2.5, 5 μg/ml Cch→TSM contraction 0, 7, 21, 40, 64, 97 (Abdel-Haq et al, 2000) L. acidissima ME AE ME AE ME AE -5, -11, -16 1, 3, 9, 15 4, 8, 11, 67, 16 2.5, 7, 12.5, 20 7, 18, 26, 36 15, 44, 17, 51 (Keyhanmanesh et al, 2007) (Boskabady, Aslani, 2005) O. basilicum ME AE ME AE 0.25, 0.5, 0.75, 1.0 KCl→TSM contraction Meth→TSM contraction 2, 2, 3, 4 3, 5, 7, 9.5 7, 11, 15, 19.5 14, 19.5, 25.5, 31 (Boskabady et al, 2005b) P and KCl-induced (fine-filled bars) contraction of tracheal smooth muscles. KCl-induced (fine-filled bars) contraction of tracheal smooth muscles.…”

Section: Resultsmentioning

confidence: 97%

“…basilicum (Boskabady et al, 2005a;Boskabady et al, 2005b), S. hortensis (Boskabady et al, 2007a) and P. anisum (Boskabady and Ramazani-Assari, 2005) was more marked on tracheal smooth muscles contracted by methacholine than by KCl, which indicates the potassium channel-opening effect of these plants.…”

Section: Potassium Channel-opening Effectmentioning

confidence: 90%

“…indicates that this effect cannot be attributed to its thymoquinone constituent (Boskabady and Aslani, 2005).…”

Section: Ferula Assa-foetidamentioning

confidence: 96%

“…All extracts had a higher relaxant effect on methacholine-induced contraction of tracheal smooth muscles than on KCl-induced contraction. In addition, thymoquinone, one of the main constituents of N. sativa, did not show any relaxant effect on methacholine-and KClinduced contraction of tracheal smooth muscles (Boskabady and Aslani, 2005). However, carvacrol, another constituent, showed a potent relaxant effect on both methacholine-and KClinduced smooth muscle contraction (Boskabady and Jandaghi, 2003), which is suggested to be responsible for the relaxant effect of N. sativa.…”

Section: Toxicological Effectsmentioning

confidence: 97%

“…Similarly, Pimpinella anisum L. (P. anisum) (Boskabady and Ramazani-Assari, 2005), Satureja hortensis L. (S. hortensis) (Boskabady et al, 2007a), Ocimum basilicum L. (O.…”

Section: Calcium Channel-blocking Effectmentioning

confidence: 98%

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A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 97%

Section: Potassium Channel-opening Effectmentioning

confidence: 90%

“…indicates that this effect cannot be attributed to its thymoquinone constituent (Boskabady and Aslani, 2005).…”

Section: Ferula Assa-foetidamentioning

confidence: 96%

Section: Toxicological Effectsmentioning

confidence: 97%

“…Similarly, Pimpinella anisum L. (P. anisum) (Boskabady and Ramazani-Assari, 2005), Satureja hortensis L. (S. hortensis) (Boskabady et al, 2007a), Ocimum basilicum L. (O.…”

Section: Calcium Channel-blocking Effectmentioning

confidence: 98%

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A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Shakeri

Boskabady

2015

Journal of Ethnopharmacology

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Effect of high fat diet on NF‐кB microRNA146a negative feedback loop in ovalbumin‐sensitized rats

et al. 2018

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The present study aimed to investigate the role of microRNA‐146a and its adapter proteins [interleukin‐1 receptor‐associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor‐associated factor 6 (TRAF6)] in the pathogenesis of ovalbumin (OVA)‐sensitized rats in association with the diet‐induced obesity condition. Twenty male Wistar rats were divided into four groups: control with normal diet (ND), OVA‐sensitized with normal diet (S + ND), high‐fat diet (HFD), and OVA‐sensitized with high‐fat diet (S + HFD). All the animals were fed for 8 weeks with standard pelts or high‐fat diet, and were then sensitized and challenged with OVA or saline for another 4 weeks. The tracheal responsiveness to methacholine, serum protein levels, and lipid profile levels was measured by the ELISA method. Moreover, the gene expression level of microRNA‐146a (miR‐146a) was measured in the lung tissue of the rats using the real‐time PCR method. Maximum response to methacholin increased in the S + HFD group in compared with ND, S + ND, and HFD groups (P < 0.05 to P < 0.001). Moreover, in the S + HFD group the mRNA expression levels of miRNA‐146a increased in the lung tissue (P < 0.001). In addition, the protein analysis results showed that IRAK1, TRAF6, NF‐kB, and IL‐1β protein levels were high in the S + HFD group compared to the ND and HFD groups; however, in compared with the S + ND group, only the IL‐1β protein level was higher in the S + HFD group (P < 0.05). These results suggest that a defect in the NF‐kB–miR‐146a negative feedback loop may be involved in the pathogenesis of obesity associated with OVA‐sensitized condition. © 2018 BioFactors, 45(1):75–84, 2019

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The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

Gholamnezhad

Ghorani

Saadat

et al. 2018

Phytotherapy Research

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Pharmacological agents that can affect muscarinic receptors are commonly used to treat or manage various diseases. Medicinal plants have been used from ancient time to treat cardiovascular, gastrointestinal, respiratory, and urogenital disorders, which may related to their muscarinic receptors effects. Several pharmacological studies revealed the inhibitory or stimulatory effect of some herbal plants on muscarinic receptors. Medline, PubMed, Science Direct, Scopus, and Google Scholar as online database were searched from the beginning of 1983 to March 2018 using following keywords: muscarinic receptor, medicinal plant, herbal medicine, and smooth muscle, animal, human, in vivo, and in vitro. The original studies in English language were included. Based on the results of the reviewed articles, more than 70 medicinal plants extracts or constituents affected muscarinic receptors (stimulatory or inhibitory) of smooth muscles in cardiovascular, gastrointestinal, respiratory, and urogenital systems. Among them, there are some tropical plant and herbs that have been traditionally used as food additive. The therapeutic properties of these plants may be regarded in treatment of cardiovascular (hypertension and tachycardia); gastrointestinal (diarrhea, colitis, and constipation); and urological (overactive bladder, abortion, and preterm labor) diseases. However, more clinical trials are needed to use some of these medicinal plants in clinical target therapy.

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Possible Mechanism for the Relaxant Effect ofPimpinella anisum. on Guinea Pig Tracheal Chains

Cited by 10 publications

References 16 publications

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency

Effect of high fat diet on NF‐кB microRNA146a negative feedback loop in ovalbumin‐sensitized rats

The effects of medicinal plants on muscarinic receptors in various types of smooth muscle

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