Poly(ε-caprolactone) filled with electrospun nylon fibres: A model for a facile composite fabrication

Neppalli, Ramesh; Marega, Carla; Marigo, Antonio; Bajgai, Madhab Prasad; Kim, Hee Young; Causin, Valerio

doi:10.1016/j.eurpolymj.2010.01.004

Cited by 94 publications

(77 citation statements)

References 40 publications

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“…Due to their high specific surface area and porous structure [2], the electrospun nonwoven fabrics that consisted of ultrafine fibers have found wide biomedical applications such as scaffolds for tissue engineering [3,4], wound dressing materials [5] and carriers for drug delivery [6]. Many polymers have been successfully electrospun as promising materials for several years [7][8][9][10]. Especially, alginate, as a biopolymer for preparing nanofibers, has attracted a lot of attention in recent years [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

et al. 2015

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As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1 H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/ PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % k-cyhalothrin during the initial period of 10 h.

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Section: Introductionmentioning

confidence: 99%

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

et al. 2015

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“…Polycaprolactone (PCL) is one of the most commonly applied synthetic polymers for medical use because of its biocompatibility and slow biodegradability [1,2,3]. By combining the favourable intrinsic properties of the polymer PCL with the unique characteristics of a nanofibrous structure a promising material for biomedical applications can be obtained [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

An alternative solvent system for the steady state electrospinning of polycaprolactone

Schueren

Schoenmaker

Kalaoğlu

et al. 2011

European Polymer Journal

240

139

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Polycaprolactone (PCL) is a biocompatible aliphatic polyester with many possible applications in the medical field. PCL nanofibres, produced by electrospinning, could provide new characteristics that are of interest for these applications. However, a key prerequisite is the ability to obtain bead-free fibres with diameters in the nanoscale range. At present the most commonly used solvent for electrospinning PCL is chloroform, but this only leads to fibres in the microscale range. Therefore various solvent systems were examined in this study.The innovative solvent mixture formic acid/acetic acid was found to allow for nanofibres with a diameter ten times smaller than chloroform. Moreover, steady state conditions could be obtained which thus allow electrospinning in a stable and reproducible way. Further it was noticed that the average fibre diameter decreased with decreasing polymer concentration while the diameter distribution decreased with increasing amount of formic acid. Also the humidity, an often overlooked yet important parameter, was noted to affect both diameter 2 characteristics. Generally it can be concluded that the solvent system formic acid/acetic acid could fill the gap in electrospinning PCL since it is readily able to produce uniform fibres in the nanoscale range.

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“…We chose to focus on polycaprolactone (PCL) as the device material because of its well established biocompatibility (12,13). There is a large body of literature on use of PCL based devices for extended delivery of many compounds (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Hybrid Electrospun Polycaprolactone Mats Consisting of Nanofibers and Microbeads for Extended Release of Dexamethasone

et al. 2016

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Poly(ε-caprolactone) filled with electrospun nylon fibres: A model for a facile composite fabrication

Cited by 94 publications

References 40 publications

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

An alternative solvent system for the steady state electrospinning of polycaprolactone

Hybrid Electrospun Polycaprolactone Mats Consisting of Nanofibers and Microbeads for Extended Release of Dexamethasone

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