“…For example, the most common thermoresponsive polymer poly( N -isopropylacrylamide) (PNIPAm) was used to copolymerize with various natural polysaccharides (such as chitosan, dextran, cellulose, mannan, etc.) to obtain polysaccharide hydrogels with thermally responsive behavior. , As chitosan contains amino groups in the chain, anionic polysaccharide alginate, polyacrylic acid or poly (methacrylic acid) with ionizable acid groups are widely used to develop pH-responsive properties of hydrogel materials through protonation and deprotonation processes. − Polysaccharide-based photoresponsive hydrogels usually require the introduction of photoresponsive chromophores (trisodium salt of copper chlorophyllinate, photoactive cinnamon garlic juice) into the gel system or the simultaneous introduction of metal nanoparticles to obtain photothermalresponsive polysaccharide hydrogels. − The polysaccharide-based conductive hydrogels combine polyelectrolyte polysaccharides with conductive metal nanoparticles, carbon nanomaterials, and conductive polymers to develop electrically responsive polysaccharide-based hydrogels. − To the best of our knowledge, there are few studies that pay attention to the responsiveness of polysaccharide hydrogels themselves, such as solvent-responsive properties, especially ethanol-responsive polysaccharide hydrogels. , Recently, there have been reports to study the effect of ethanol on the molecular chain of xanthan gum, but the studies on the interaction between polysaccharide hydrogels and ethanol limits in the evaluation of swelling–deswelling behavior of hydrogel drug-loaded systems. , In previous studies, ethanol has been used to prepare multimembrane hydrogel systems with microstructures and used in cell culture, , confirming the potential of ethanol in constructing functional polysaccharide hydrogels. Therefore, it is necessary to broaden the response behavior of polysaccharides to ethanol.…”