The transplantation of human mesenchymal stem cells (hMSCs), such as bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs), has shown beneficial effects in protecting transplanted tissues and cells...

The binding of stem cells with a peptide-immobilized material surface, where several peptides are designed and conjugated on the material with multiple reactions, activates several signaling pathways that determine the stem cell fate.

Human pluripotent stem cells (hPSCs) have the ability to differentiate into cells derived from three germ layers and are an attractive cell source for cell therapy in regenerative medicine. However,...

Purpose: To explore the research areas, hotspots, and progress of meibomian gland dysfunction through bibliometrics.Methods: Related publications were retrieved from the Web of Science Core Collection from 2011 to 2020. VOSviewer1.6.16, Citespace.5.7. R2, and GraphPad Prism 8 were used to visualize the distribution of countries, research institutions, journals, authors, keywords, and annual publication numbers in this field.Results: A total number of 716 relevant publications were retrieved. The United States and Keio University ranked the first among the countries and organizations with the most publications. Cornea, Investigative Ophthalmology & Visual Science, and Ocular Surface were the top three journals with the highest publication counts and citations. The authors who contributed to this topic mainly formed three clusters which manifested the research areas, and the extracted keywords mainly formed four clusters which manifested the hotspots were explored. The research areas and hotspots of meibomian gland dysfunction were as follow: (1) Pathogenesis or potential etiology of meibomian gland dysfunction; (2) Diagnosis of meibomian gland dysfunction; (3) Therapy of meibomian gland dysfunction and the International Workshop`s dedication to it; (4) Epidemiology of meibomian gland dysfunction.Conclusions: In the last ten years, hundreds of publications revealed that the pathogenesis, diagnosis, epidemiology, and therapy were the research hotspots in meibomian gland dysfunction research area.

Background To explore the research areas, hotspots, and progress of meibomian gland dysfunction through bibliometrics. Methods Related publications were retrieved from the Web of Science Core Collection from 2011 to 2020. VOSviewer1.6.16, Citespace.5.7.R2, and GraphPad Prism 8 were used to visualize the distribution of countries, research institutions, journals, authors, keywords, and annual publication numbers in this field. Results A total number of 716 relevant publications were retrieved. The United States and Keio University ranked the first among the countries and organizations with the most publications. Cornea, Investigative Ophthalmology & Visual Science, and Ocular Surface were the top three journals with the highest publication counts and citations. The authors who contributed to this topic mainly formed three clusters which manifested the research areas, and the extracted keywords mainly formed four clusters which manifested the hotspots were explored. Conclusions The research areas and hotspots of meibomian gland dysfunction were as follow: (1) Pathogenesis or potential etiology of meibomian gland dysfunction; (2) Diagnosis of meibomian gland dysfunction; (3) Therapy of meibomian gland dysfunction and the International Workshop`s dedication to it; (4) Epidemiology of meibomian gland dysfunction.