Poly Lactic Acid Fibre Based Biodegradable Stents and Their Functionalization Techniques

Rebelo, Rita; Vila, Nívea Taís; Rana, Sohel; Fangueiro, Raúl

doi:10.1007/978-94-017-7515-1_25

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Chitosan is the second most abundant polymer, after cellulose. It is a cationic polysaccharide produced by deacetylation of chitin, which is found in the exoskeletons of insects, the cell walls of fungi, and certain hard structures in invertebrates and fish [78,86]. This natural polymer is structurally composed of N -acetyl- d -glucosamine and d -glucosamine units with one amino (NH 2 ) group and two hydroxyl (–OH) groups in each repeating glycosidic units [87].…”

Section: Polymers Used For Implantable Polymeric Drug Delivery Devmentioning

confidence: 99%

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

et al. 2018

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The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.

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Section: Polymers Used For Implantable Polymeric Drug Delivery Devmentioning

confidence: 99%

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

et al. 2018

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“…For several years now, chitosan has been of interest in many studies that have shown that it can be used to prolong storage of an array of fruit and vegetables worldwide, where it has been shown to have three major activities: including biofilm formation on treated surfaces (El Ghaouth, Arul, Ponnampalam, & Boulet, 1991; Romanazzi et al., 2018; Valencia‐Chamorro, Palou, & Del Río, 2011); as an antimicrobial (Cheung, Ng, Wong, & Chan, 2015; Duan et al., 2019; Feliziani, Landi, & Romanazzi, 2015; Goy, De Britto, & Assis, 2009; Kong, Chen, Xing, & Park, 2010; Pétriacq, López, & Luna, 2018; Wang, Li, & Zhang, 2017); and as an elicitor of host defense mechanisms (Colman et al., 2019; Coqueiro et al., 2015; Landi et al., 2017; Landi, Feliziani, & Romanazzi, 2014; Obianom, Romanazzi, & Sivakumar, 2019; Xoca‐Orozco et al., 2019). For these reasons, chitosan can be used as a biodegradable fungicide (Liang et al., 2017; Rebelo, Vila, Rana, & Fangueiro, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chitosan and postharvest decay of fresh fruit: Meta‐analysis of disease control and antimicrobial and eliciting activities

Rajestary

Landi

Romanazzi

2020

Comp Rev Food Sci Food Safe

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Consumers are increasingly aware of the importance of regular consumption of fresh fruit in their diet. Since fresh fruit are highly sensitive to postharvest decay, several investigations focused on the study natural compounds alternative to synthetic fungicides, to extend their shelf life. A long list of studies reported the effectiveness of the natural biopolymer chitosan in control of postharvest diseases of fresh fruit. However, these findings remain controversial, with many mixed claims in the literature. In this work, we used random‐effects meta‐analysis to investigate the effects of 1% chitosan on (a) postharvest decay incidence; (b) mycelium growth of fungal pathogens Botrytis cinerea, Penicillium spp., Colletotrichum spp. and Alternaria spp.; and (c) phenylalanine ammonia‐lyase, chitinase and β‐1,3‐glucanase activities. Chitosan significantly reduced postharvest disease incidence (mean difference [MD], −30.22; p < 0.00001) and in vitro mycelium growth (MD, −54.32; p < 0.00001). For host defense responses, there were significantly increased activities of β‐1,3‐glucanase (MD, 115.06; p = 0.003) and chitinase (MD, 75.95; p < 0.0002). This systematic review contributes to confirm the multiple mechanisms of mechanisms of action of chitosan, which has unique properties in the natural compound panorama. Chitosan thus represents a model plant protection biopolymer for sustainable control of postharvest decay of fresh fruit.

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“…Alloys for stents have been designed previously based on desired mechanical properties, which has led to a decrease in environment interaction control. 73 Most mechanisms consist of the introduction of a polymeric layer on the surface of the stent to inhibit cellular adhesion. 155 Polymeric coatings deposited on the stent surface are also aimed at improving corrosion resistance and biocompatibility and reducing the risk of thrombosis.…”

Section: Surface Polymer Coatingsmentioning

confidence: 99%

“…Studies in which the objectives were the total elimination of the metallic stent have been reviewed. − The premise consisted of the design of stents based on polymeric materials that are capable of eventually being fully resorbed by the body. The theoretical advantages of these designs promised flexion in the blood vessel, less cyclical wear on the arterial walls, and an adaptive vascular response .…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

“…A number of polymers have been selected for the incorporation of drugs onto the stent surface. Alloys for stents have been designed previously based on desired mechanical properties, which has led to a decrease in environment interaction control . Most mechanisms consist of the introduction of a polymeric layer on the surface of the stent to inhibit cellular adhesion .…”

Section: Surface Polymer Coatingsmentioning

confidence: 99%

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Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

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Poly Lactic Acid Fibre Based Biodegradable Stents and Their Functionalization Techniques

Cited by 8 publications

References 24 publications

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

Chitosan and postharvest decay of fresh fruit: Meta‐analysis of disease control and antimicrobial and eliciting activities

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

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