Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

Stewart, Sarah A.; Domínguez-Robles, Juan; Donnelly, Ryan F.; Larrañeta, Eneko

doi:10.3390/polym10121379

Cited by 261 publications

(191 citation statements)

References 139 publications

Supporting

Mentioning

186

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, chemotherapeutic approaches are focused on the design of the biomaterial-based structures able to act locally, in order to enhance treatment and minimize the side effects of therapy. 1,2 This new concept of a regional chemotherapy makes it necessary to design novel types of polymeric materials that exhibit cytostatic properties or that can act as the carriers for anti-cancer agents.…”

Section: Introductionmentioning

confidence: 99%

Novel polymeric derivatives of betulin with anticancer activity

et al. 2019

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Novel polymeric derivatives of betulin with anticancer activity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Polycaprolactone is a non-toxic, degradable, biocompatible and absorbent polymer that does not produce harmful byproducts (Cho, 2014;Teo et al 2015). It is approved by the US Food and Drug Administration for use in various devices for medical applications, including implants, drug delivery devices, and sutures (Place et al 2009;Stewart et al 2018). PCL implants will disintegrate after more than 2 years (Gunatillake & Adhikari, 2003), stimulating osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Restoration of the inferomedial orbital strut using a standardized three‐dimensional printing implant

Kim

Lee

et al. 2019

Journal of Anatomy

View full text Add to dashboard Cite

The inferomedial orbital strut (IOS) is the thin bony junction of the orbital medial wall and floor. Its fracture is common and leads to serious complications, including enophthalmos, globe dystopia and diplopia. However, anatomical restoration of the IOS is challenging owing to reduced structural support; sound anatomical background and accurate implants are therefore essential. The aim of the present study was to incorporate data from cadaveric orbit anatomy into three-dimensional (3D) printing technology and to reconstruct the complex orbital fracture elaborately. After averaging the data from computed tomography (CT) images of 100 adult cadavers, the dimensions of the IOS were extracted, and a tangent sphere was created using a computeraided design program. The curves were compared with the CT data of 10 adult patients from the simulation test. Based on these data, a standardized 3D implant, 1.15 mm thick, was designed using polycaprolactone. The implant was placed in five patients with complex orbital fractures. The radius of the sphere in contact with the orbit, measuring 33.54 mm, was confirmed to be appropriate. A comparison between the normal side volume (V0) and the postoperative volume (V post ) showed that they were statistically similar. Furthermore, a comparison between V0 and the preoperative volume (V pre ), and V post compared with V pre also showed a statistically significant difference (P < 0.05). On follow-up, the preoperative ocular symptoms were resolved. The orbital data obtained from 100 cadavers provided standardized orbital anatomy, and 3D printed implants were created. The implants were anatomically accurate with regard to the orbital cavity and adequately covered the simulation model. The implant also showed satisfactory results when applied clinically in actual patients.

show abstract

“…3Dprinted systems allow more efficient drug delivery as their geometry and design are capable of providing sustained/unattended drug release (e.g. vaginal rings and implants [4]) and the possibility of administering drug across biological barriers (e.g. microneedles [5]).…”

Section: D Printingmentioning

confidence: 99%