Poly(glycidyl methacrylate) coated dual mode upconverting nanoparticles for neuronal cell imaging

Abstract

NaGdF4:Yb,Er nanoparticles with a functional poly(glycidyl methacrylate) (PGMA) coating, as a biocompatible multimodal formulation for neuronal cell imaging.

Poly(4-Styrenesulfonic Acid-co-maleic Anhydride)-Coated NaGdF4:Yb,Tb,Nd Nanoparticles with Luminescence and Magnetic Properties for Imaging of Pancreatic Islets and β-Cells

“…The larger hydrodynamic diameter than the number-average size of the particles according to TEM indicated their slight tendency for aggregation. By comparison, the post-synthesis modification of NaGdF 4 nanoparticles with poly­(glycidyl methacrylate) or poly­(ethylene glycol)- b -poly­(pentafluorophenyl methacrylate) resulted in high hydrodynamic sizes of 171 or 142 nm, respectively. , Also, the NaGdF 4 @SiO 2 particles prepared from gadolinium oxide, perchloric acid, and sodium fluoride in the presence of trisodium citrate were relatively large, 120–250 nm in diameter, which is not optimal for labeling of pancreatic islets with a typical size of ∼100 μm.…”

“…The larger hydrodynamic diameter than the number-average size of the particles according to TEM indicated their slight tendency for aggregation. By 48,49 Also, the NaGdF 4 @SiO 2 particles prepared from gadolinium oxide, perchloric acid, and sodium fluoride in the presence of trisodium citrate were relatively large, 120−250 nm in diameter, 50 which is not optimal for labeling of pancreatic islets with a typical size of ∼100 μm. XPS, FTIR, and TGA Characterization.…”

Neuro‐Nano Interfaces: Utilizing Nano‐Coatings and Nanoparticles to Enable Next‐Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation

“…This upconverted light then activates neurons surrounding the particle. This system is useful because it enables the exposure of cells to visible light without any implanted optical device; furthermore, the optoelectronic properties of UCNPs are chemically robust and photo‐stable, making them suitable for long‐term application in the CNS and other biomedical applications . Specifically, UCNPs are gaining momentum as alternative neuro‐nano interfaces and optogenetic transducers because early reports suggest negligible toxicity at low dosage; however, there is significant research that needs to be carried out to elucidate the mechanisms of the long‐term biodistribution and potential toxicity of UCNPs.…”

“…This can be achieved through the addition of MRI of the UCNPs during IR radiation. To this end, Smith et al used a NaGdF 4 :Yb,Er core particle with a poly(glycidyl methacrylate) (PGMA) coating . Using NIR radiation, these UCNPs were heated to excite neurons, and then tracked via MRI.…”