to record or modulate electrical activity of the nervous system. Although these electrode systems are both mechanically and operationally robust, they have limited utility due to the resultant macroscale damage from invasive implantation. For this reason, novel nanomaterials are being investigated to enable new strategies to chronically interact with the nervous system at both the cellular and network level. In this feature article, the use of nanomaterials to improve current electrophysiological interfaces, as well as enable new nano-interfaces to modulate neural activity via alternative mechanisms, such as remote transduction of electromagnetic fields are explored. Specifically, this article will review the current use of nanoparticle coatings to enhance electrode function, then an analysis of the cuttingedge, targeted nanoparticle technologies being utilized to interface with both the electrophysiological and biochemical behavior of the nervous system will be provided. Furthermore, an emerging, specialized-use case for neural interfaces will be presented: the modulation of the blood-brain barrier.

In article number https://doi.org/10.1002/adfm.201700239, Michael Daniele and co‐workers evaluate the state‐of‐the‐art in next‐generation neuro‐nano interfaces. Functional nanomaterials are being developed to improve neural implants, as well as, enable the modulation of neural activity and blood‐brain barrier function via the remote transduction of optical and electromagnetic fields.

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