Results taken from 270 publications on rates are summarized, and collated with those from 149 publications reriewed previously (Young, 1969(Young, ,1974. The data are classified by major climatic zone, normal or steep relief, and consolid ited or unconsolidated rocks. Representative rates and their ranges are given for soil creep, solifluction, surface wash, solution (chemical denudation), rock weathering, slope retreat, cliff (free face) retreat, marine cliff retreat, and denudation, the last being compared with representative rates of uplift. Solifluction is of the order of 10 times faster than soil creep, but both cause only very slow ground loss. Solution is an important cause of ground loss for siliceous rocks, on which it may be half as rapid as on limestones. Total denudation, brought about mainly by surface wash, reaches a maximum in the semi-arid and probably also the tropical savanna zones. Acceleration of natural erosion rates by human activities ranges from 2-3 times with moderately intense land use to about 10 times with intensive land use (and considerably higher still where there is recognized accelerated soil erosion). Where there is active uplift, typical rates are of the order of 10 times faster than denudation, although in some high, steep mountain ranges these may approach equality.
Abstract. The most sensitive direct method to establish the absolute neutrino mass is observation of the endpoint of the tritium beta-decay spectrum. Cyclotron Radiation Emission Spectroscopy (CRES) is a precision spectrographic technique that can probe much of the unexplored neutrino mass range with O(eV) resolution. A lower bound of m(ν e ) 9(0.1) meV is set by observations of neutrino oscillations, while the KATRIN Experiment -the current-generation tritium beta-decay experiment that is based on Magnetic Adiabatic Collimation with an Electrostatic (MAC-E) filter -will achieve a arXiv:1703.02037v1 [physics.ins-det]
Diagnostic study, Level III (Study of nonconsecutive patients; without consistently applied reference "gold" standard). See the Guidelines for Authors for a complete description of levels of evidence.
Cardiovascular disease is the leading cause of mortality in the world. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. A platelet-inspired nano-cell (PINC) that incorporates both prostaglandin E2 (PGE 2 )-modified platelet membrane and cardiac stromal cellsecreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct-homing ability of platelet membrane and the overexpression of PGE 2 receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targeted delivery of therapeutic payload to the injured heart. Furthermore, a synergistic treatment efficacy can be This article is protected by copyright. All rights reserved. 3 achieved by PINC, which combines the paracrine mechanism of stem cell therapy with the PGE 2 /EP receptor signaling that is involved in the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R injury, intravenous injection of PINCs results in augmented cardiac function and mitigated heart remodeling, which is accompanied by the increase in cycling cardiomyocytes, activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This approach represents a promising therapeutic delivery platform for treating I/R injury.
Synthetically modified proteins, such as gelatin methacryloyl (GelMA), are growing in popularity for bioprinting and biofabrication. GelMA is a photocurable macromer that can rapidly form hydrogels, while also presenting bioactive peptide sequences for cellular adhesion and proliferation. The mechanical properties of GelMA are highly tunable by modifying the degree of substitution via synthesis conditions, though the effects of source material and thermal gelation have not been comprehensively characterized for lower concentration gels. Herein, the effects of animal source and processing sequence are investigated on scaffold mechanical properties. Hydrogels of 4–6 wt% are characterized. Depending on the temperature at crosslinking, the storage moduli for GelMA derived from pigs, cows, and cold‐water fish range from 723 to 7340 Pa, 516 to 3484 Pa, and 294 to 464 Pa, respectively. The maximum storage moduli are achieved only by coordinated physical gelation and chemical crosslinking. In this method, the classic thermo‐reversible gelation of gelatin occurs when GelMA is cooled below a thermal transition temperature, which is subsequently “locked in” by chemical crosslinking via photocuring. The effects of coordinated physical gelation and chemical crosslinking are demonstrated by precise photopatterning of cell‐laden microstructures, inducing different cellular behavior depending on the selected mechanical properties of GelMA.
Cardiac stem cell (CSC) therapy has shown preclinical and clinical evidence for ischemic heart repair but is limited by low cellular engraftment and survival after transplantation. Previous versions of the cardiac patch strategy improve stem cell engraftment and encourage repair of cardiac tissue. However, cardiac patches that can enhance cardiomyogenesis and angiogenesis at the injured site remain elusive. Therapies that target cardiomyocyte proliferation and new blood vessel formation hold great potential for the protection against acute myocardial infarction (MI). Here, we report a new strategy for creating a vascularized cardiac patch in a facile and modular fashion by leveraging microfluidic hydrodynamic focusing to construct the biomimetic microvessels (BMVs) that include human umbilical vein endothelial cells (HUVECs) lining the luminal surface and then encapsulating the BMVs in a fibrin gel spiked with human CSCs. We show that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture. In a rat model of acute MI, the BMV-CSC patch therapy induced profound mitotic activities of cardiomyocytes in the peri-infarct region 4 weeks post-treatment. A significant increase in myocardial capillary density was noted in the infarcted hearts that received BMV-CSC patch treatment compared to the infarcted hearts treated with conventional CSC patches. The striking therapeutic benefits and the fast and facile fabrication of the BMV-CSC patch make it promising for practical applications. Our findings suggest that the BMV-CSC patch strategy may open up new possibilities for the treatment of ischemic heart injury.
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