Poly(glutamic acid): Production, composites, and medical applications of the next-generation biopolymer

Park, Sung-Bin; Sung, Moon-Hee; Uyama, Hiroshi; Han, Dong Keun

doi:10.1016/j.progpolymsci.2020.101341

Cited by 82 publications

(66 citation statements)

References 150 publications

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“…[ [130][131][132] Cartilage regeneration Microsphere developed from γ-PGA/chitosan showed propagation and attachment of chondrocytes forming fibrous tissue.…”

Section: Medicinementioning

confidence: 99%

Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization

Nair

Navale

Dharne

2021

Biomass Conv. Bioref.

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Poly-gamma-glutamic acid (γ-PGA) is a biodegradable, non-toxic, ecofriendly, and non-immunogenic biopolymer. Its phenomenal properties have gained immense attention in the field of regenerative medicine, the food industry, wastewater treatment, and even in 3D printing bio-ink. The γ-PGA has the potential to replace synthetic non-degradable counterparts, but the main obstacle is the high production cost and lower productivity. Extensive research has been carried out to reduce the production cost by using different waste; however, it is unable to match the commercialization needs. This review focuses on the biosynthetic mechanism of γ-PGA, its production using the synthetic medium as well as different wastes by L-glutamic acid-dependent and independent microbial strains. Furthermore, various metabolic engineering strategies and the recovery processes for γ-PGA and their possible applications are discussed. Finally, highlights on the challenges and unique approaches to reduce the production cost and to increase the productivity for commercialization of γ-PGA are also summarized.

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“…[ [130][131][132] Cartilage regeneration Microsphere developed from γ-PGA/chitosan showed propagation and attachment of chondrocytes forming fibrous tissue.…”

Section: Medicinementioning

confidence: 99%

Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization

Nair

Navale

Dharne

2021

Biomass Conv. Bioref.

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“…Other synthetic polymers that have attracted research interest for delivery purposes include, but are not limited to, poly β-hydroxybutyrate [159,160], polyurethane (PU) [161,162], polyvinyl pyrrolidone (PVP) [163][164][165], poly (γ-glutamic acid) (PGA) [166,167], and polymethyl methacrylate [168][169][170].…”

Section: Other Synthetic Polymersmentioning

confidence: 99%

Polymer-Based Nanosystems—A Versatile Delivery Approach

Niculescu

Grumezescu

2021

Materials

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Polymer-based nanoparticles of tailored size, morphology, and surface properties have attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting the payload from degradation and maintaining sustained and controlled release of the drug, polymeric nanoparticles can reduce drug clearance, increase their cargo’s stability and solubility, prolong its half-life, and ensure optimal concentration at the target site. The inherent immunomodulatory properties of specific polymer nanoparticles, coupled with their drug encapsulation ability, have raised particular interest in vaccine delivery. This paper aims to review current and emerging drug delivery applications of both branched and linear, natural, and synthetic polymer nanostructures, focusing on their role in vaccine development.

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“…Poly(amino acid)s belong to the polyamides family forming only a single type of amino acid making them different from multi amino acid polyamides such as proteins. Among the poly(amino acid)s discovered to date, poly(glutamic acid) (PGA) has attracted the most attention due to itsnon-toxicity, water-solubility, excellent biocompatibility, and high functionability 23 – 26 . Owing to these features, PGA materials and composites have been promising in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Application of green synthesized WO3-poly glutamic acid nanobiocomposite for early stage biosensing of breast cancer using electrochemical approach

Nasrollahpour

Naseri

Rashidi

et al. 2021

Sci Rep

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Biopolymer films have drawn growing demand for their application in the point of care domain owing to their biocompatibility, eco-friendly, and eligibility for in vivo analyses. However, their poor conductivity restricts their sensitivity in diagnostics. For high-quality electrochemical biosensor monitoring, two vital factors to be greatly paid attention are the effective merge of amplification modifiers with transducing surface and the superior linking across the recognition interface. Here, we introduce an enzyme-free electrochemical biosensor based on electrosynthesized biocompatible WO3/poly glutamic acid nano-biocomposites to address the hardships specific to the analysis of circulating proteins clinical samples. In addition to its green synthesis route, the poor tendency of both components of the prepared nano-biocomposite to amine groups makes it excellent working in untreated biological samples with high contents of proteins. Several electrochemical and morphological investigations (SEM, EDX, and dot mapping) were fulfilled to gain a reliable and trustful standpoint of the framework. By using this nanobiosensor, the concentration of HER-2 was detectable as low as 1 fg mL−1 with a wide linear response between 1 ng mL−1 and 1 fg mL−1. Meanwhile, the protocol depicted ideal specificity, stability, and reproducibility for the detection of HER-2 protein in untreated serum samples of breast cancer patients.

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Poly(glutamic acid): Production, composites, and medical applications of the next-generation biopolymer

Cited by 82 publications

References 150 publications

Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization

Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization

Polymer-Based Nanosystems—A Versatile Delivery Approach

Application of green synthesized WO3-poly glutamic acid nanobiocomposite for early stage biosensing of breast cancer using electrochemical approach

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