Poly(diethyl methylidenemalonate) Nanoparticles as a Potential Drug Carrier: Preparation, Distribution and Elimination after Intravenous and Peroral Administration to Mice

Keyser, J.-L. De; Poupaert, Jacques H.; Dumont, Pierre

doi:10.1002/jps.2600800117

Cited by 32 publications

(3 citation statements)

References 18 publications

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“…The nanoparticle is a passive target preparation and transported through the peyer's pathes in gastrointestinal tract. When the particle diameter of the nanoparticle is less than 200nm, it can be captured by reticuloendothelial system, especially by the Kupffer cell in the liver [5]. On the other hand, nanoparticle may increase the absorption and prolong efficacy and also reduce toxicity in vivo.…”

Section: Intruductionmentioning

confidence: 98%

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Xue-nong

Gong²,

Tang³

et al. 2008

CNANO

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Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole-polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution.

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Section: Intruductionmentioning

confidence: 98%

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Xue-nong

Gong²,

Tang³

et al. 2008

CNANO

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“…The mechanisms of the improved efficacy of drug delivery systems using nanocarriers have been extensively researched. Previous studies have shown that nano-and microparticles are easily taken up by a group of localized endothelial cells in the small intestine, especially by Peyer's patch [7][8][9][10]. Therefore, the drug absorption is highly increased.…”

Section: Oral Administrationmentioning

confidence: 99%

Drug Delivery Strategies for Treating Osteoporosis

Zhang

Dusad²,

Ren³

2014

Orthopedic Muscul Sys

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Osteoporosis is characterized by a decrease in bone mass and micro architectural deterioration of bone tissue. Current treatments for osteoporosis are generally associated with many limitations, including low oral bioavailability, short half time and long-term side effects. Drug delivery systems are developed to reduce off-target side effects, protect drugs from degradation and control release of the therapeutic agents at the desired sites. This review presents current research strategies adopted for delivery anti-osteoporosis agents. Oral delivery systems were developed to facilitate the oral administration of protein drugs. Targeted delivery systems based on bone seeking agents (such as bisphosphonate) greatly enhanced the distribution of therapeutic agents to bone tissue. Local administration based on nanoparticles and hydrogels slowly released incorporated drugs and remained a sustained therapeutic effect in disease site. Though the effects of these systems have been widely approved in animal models, further researches are needed for a bench-to-bedside transition.

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“…Unlike cyanoacrylates, methylidene malonates have been shown to produce narrower weight distributions (Đ = 1.63 compared to 2.14), better biocompatibility, and more controlled reactivity (less sensitive to moisture for example). 16,24,25 Some reversible-deactivation radical polymerization schemes can occur in the presence of oxygen or air, but usually require elevated temperatures, mitigation of moisture, and/or complicated processes to graft initiators to the substrate prior to polymerization. [26][27][28][29] Thus, this study evaluates the grafting and polymerization of methylidene malonates under practical conditions, i.e., in the presence of air and water.…”

Section: Introductionmentioning

confidence: 99%

Anionic polymerization and transport of diethyl methylidene malonate on polyolefin copolymer surfaces

2023

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Poly(diethyl methylidenemalonate) Nanoparticles as a Potential Drug Carrier: Preparation, Distribution and Elimination after Intravenous and Peroral Administration to Mice

Cited by 32 publications

References 18 publications

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Drug Delivery Strategies for Treating Osteoporosis

Anionic polymerization and transport of diethyl methylidene malonate on polyolefin copolymer surfaces

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