Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Xue-nong, Zhang; Gong, Jinhong; Tang, Lihua; Qiang, Zhang

doi:10.2174/157341308783591834

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…Several studies have been conducted on the use of albendazole along with surgery and have shown satisfactory results in the treatment of patients (29), but an appropriate formulation to increase the efficacy of the drug has not been found yet. Nano-particles are among the appropriate drug carriers for loading and transferring drugs (30).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Protoscolicidal Effects of Albendazole and Albendazole Loaded Solid Lipid Nanoparticles

Aminpour¹,

Rafiei²,

Jelowdar

et al. 2019

IJPA

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Background: Protoscolex plays an important role in the development of hydatid cyst. Albendazole is one of the most effectual protoscolicidal agents for averting the reappearance of this disease, nonetheless, its low solubility and its low intestinal absorption necessitates the presence of a drug carrier to enhance its efficacy. In this study, the effect of albendazole and its nano-form on protoscolices in cultured media and in vivo was evaluated. Methods: Microemulsion method was used to prepare the Solid lipid nanoparticles (SLNs) containing albendazole. Infected livers were collected from the Slaughterhouse of Ahvaz, Khuzestan in 2017. The protoscolices were stored in RPMI 1640 for one week, and their survival under the influence of albendazole and nano-albendazole on days 3 and 7 at concentrations of 250 and 500µg / ml was investigated. The live protoscolices exposed on day 3 at a concentration of 250 μg/ml were injected to mice for evaluation of pathogenicity. Three months later, after autopsy of the mice, the pathogenicity was evaluated. Results: Protoscolicidal efficacy was highest in both concentrations on day 7 for albendazole and on day 5 for nano-albendazole. Following the autopsy of the mice, cyst growth was reported in all mice, and only two mice from the albandazole loaded SLNs group did not have any cyst. Conclusion: Albendazole loaded SLNs showed a higher protoscolicidal property than the free form of this drug; therefore, the use of nano-formulation of this drug is recommended to prevent the onset of this disease.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Protoscolicidal Effects of Albendazole and Albendazole Loaded Solid Lipid Nanoparticles

Aminpour¹,

Rafiei²,

Jelowdar

et al. 2019

IJPA

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Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

et al. 2013

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To improve the treatment of helminthiasis, filariasis, and colorectal cancer, albendazole-associated chitosan nanoparticles (ABZ-CS-NPs) were prepared using the emulsion crosslinking volatile technique with contained sodium tripolyphosphate as the crosslinking agent and Poloxamer 188 as the auxiliary solvent. The structural characteristics of the NPs were determined using X-ray diffraction to analyze the interaction between CS and the drug. The NPs were then evaluated in terms of their physicochemical characteristics, drug release behavior, in vivo pharmacokinetic parameters, and biodistribution in animal studies. ABZ-loaded NPs with a uniformly spherical particle sizes (157.8 ± 2.82 nm) showed efficient drug loading, encapsulated efficiency, and high physical stability. The drug release from ABZ-CS-NPs was extended over several periods. Kinetic models were then fitted to determine the release mechanisms. ABZ and its metabolite albendazole sulfoxide (ABZSX) were analyzed in rats with mebendazole as the internal standard using reversed-phase high-performance liquid chromatography. Compared with the ABZ suspension groups, the relative bioavailability values of ABZ and ABZSX were 146.05 and 222.15%, respectively. In addition, the plasma concentration versus time curve is consistent with that of the two compartment models in the plasma concentration versus time curve. The results indicate that the ABZ-loaded NPs are promising novel ABZ candidates for passive diffusion in the treatment of hydatid cysts in the liver via oral administration.

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Study of the interaction of β-cyclodextrin with albendazole in aqueous solutions

Stępniak

Buczkowski

Zavodnik

et al. 2017

Journal of Molecular Liquids

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Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Cited by 6 publications

References 9 publications

Evaluation of the Protoscolicidal Effects of Albendazole and Albendazole Loaded Solid Lipid Nanoparticles

Evaluation of the Protoscolicidal Effects of Albendazole and Albendazole Loaded Solid Lipid Nanoparticles

Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

Study of the interaction of β-cyclodextrin with albendazole in aqueous solutions

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