Osteoporosis is characterized by a decrease in bone mass and micro architectural deterioration of bone tissue. Current treatments for osteoporosis are generally associated with many limitations, including low oral bioavailability, short half time and long-term side effects. Drug delivery systems are developed to reduce off-target side effects, protect drugs from degradation and control release of the therapeutic agents at the desired sites. This review presents current research strategies adopted for delivery anti-osteoporosis agents. Oral delivery systems were developed to facilitate the oral administration of protein drugs. Targeted delivery systems based on bone seeking agents (such as bisphosphonate) greatly enhanced the distribution of therapeutic agents to bone tissue. Local administration based on nanoparticles and hydrogels slowly released incorporated drugs and remained a sustained therapeutic effect in disease site. Though the effects of these systems have been widely approved in animal models, further researches are needed for a bench-to-bedside transition.
Rheumatoid Arthritis (RA) is a chronic autoimmune disease and considered to be one of the major public health problems worldwide. In the past decade numerous drug delivery systems have been developed to improve the treatment outcome of RA. A stable endogenous protein, albumin has been employed as a non-immunogenic delivery carrier and extensively researched in various disease therapies. To provide the prospective for future research, this review summarizes the application of albumin as drug or imaging agent carriers for RA and proposes potential future directions. There are three major types of albumin-based carrier systems for RA, including albumin drug conjugates, albumin particles and genetic infusion albumin. Their imaging or therapeutic effects have been proved in clinic or preclinical studies.Citation: Ren K, Dusad A, Dong R, Quan L (2013) Albumin as a Delivery Carrier for Rheumatoid Arthritis.
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