Poly(acrylic acid) nanocomposites: Design of advanced materials

Kausar, Ayesha

doi:10.1177/8756087920981615

Cited by 30 publications

(20 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also acts as a super-adsorbent polymer, which makes it helpful in removing organic pollutants. The PAA with a high carboxylic group density could improve the hydrophilicity of the resultant nanocomposite . CS with functional groups −OH and −NH 2 is grafted to hydrophilic vinyl monomers via polymerization.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan-Grafted Polyacrylic Acid-Doped Copper Oxide Nanoflakes Used as a Potential Dye Degrader and Antibacterial Agent: In Silico Molecular Docking Analysis

et al. 2022

View full text Add to dashboard Cite

This study examined the catalytic and bactericidal properties of polymer-doped copper oxide (CuO). For this purpose, a facile co-precipitation method was used to synthesize CuO nanostructures doped with CS-g-PAA. Various concentrations (2, 4, and 6%) of dopants were systematically incorporated into a fixed amount of CuO. The prepared samples were analyzed by different optical, structural, and morphological characterizations. Field emission scanning electron microscopy and transmission electron microscopy micrographs indicated that doping transformed CuO’s agglomerated rod-like surface morphology to form nanoflakes. UV–vis spectroscopy revealed that the optical spectra of the samples exhibit a redshift after doping, leading to a decrease in band gap energy from 3.3 to 2.5 eV. The purpose of the study was to test the catalytic activity of pristine and CS-g-PAA doped CuO for the degradation of methylene blue in acidic, basic, and neutral conditions using NaBH4 as a reducing agent in an aqueous medium. Furthermore, antibacterial activity was evaluated against Gram-positive and Gram-negative bacteria, namely, Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Overall, enhanced bactericidal performance was observed upon doping CS-g-PAA into CuO, i.e., 4.25–6.15 and 4.40–8.15 mm against S. aureus and 1.35–4.20 and 2.25–5.25 mm against E. coli at the lowest and highest doses, respectively. The relevant catalytic and bactericidal action mechanisms of samples are also proposed in the study. Moreover, in silico molecular docking studies illustrated the role of these prepared nanomaterials as possible inhibitors of FabH and FabI enzymes of the fatty acid biosynthetic pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Further, it exhibits a high capacity to eliminate pollutants from water, significantly exceeding that of activated carbon . Polyacrylic acid (PAA) is also a commercially cost-effective polymer produced by combining acrylic acid monomers . PAA behaves as an anionic polymer in water due to the loss of protons .…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Grafted Polyacrylic Acid-Doped Copper Oxide Nanoflakes Used as a Potential Dye Degrader and Antibacterial Agent: In Silico Molecular Docking Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The mechanical characteristics of PAA are improved by crosslinking it. Polymeric moderators in PAA might even help increase their tensile strength [ 48 ]. Furthermore, the cross-linked PAA has an incredible amount of water absorption.…”

Section: Synthesis and Structure Characteristicsmentioning

confidence: 99%

“…Furthermore, cross-linked PAA can be employed as a medicinal adhesive due to its excellent bonding strength. PAA has hardness and barrier qualities in film form, making it ideal for packaged food [ 48 , 52 ]. Poly (acrylic acid) varies its characteristics in response to changes in ionic strength and pH; for example, at pH < 4, precipitate occurs in aqueous solutions due to the carboxylate groups’ protonation making the polymer sparsely soluble in water [ 53 ].…”

Section: Synthesis and Structure Characteristicsmentioning

confidence: 99%

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

et al. 2022

View full text Add to dashboard Cite

Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA. For example, nano-particles produced from PAA derivatives can be used to deliver drugs due to their stability and biocompatibility. PAA and its nanoconjugates could also be regarded as stimuli-responsive platforms that make them ideal for drug delivery and antimicrobial applications. These properties make PAA a good candidate for conventional and novel drug carrier systems. Here, we started with synthesis approaches, structure characteristics, and other architectures of PAA nanoplatforms. Then, different conjugations of PAA/nanostructures and their potential in various fields of nanomedicine such as antimicrobial, anticancer, imaging, biosensor, and tissue engineering were discussed. Finally, biocompatibility and challenges of PAA nanoplatforms were highlighted. This review will provide fundamental knowledge and current information connected to the PAA nanoplatforms and their applications in biological fields for a broad audience of researchers, engineers, and newcomers. In this light, PAA nanoplatforms could have great potential for the research and development of new nano vaccines and nano drugs in the future.

show abstract

“…13 Negatively charged polymers can be considered an intermediate case, which generally show lower cellular interactions than their positively charged counterparts and different uptake preferences. 14 Carboxylated polymers are one important class of anionic polymers, which can be divided into natural carboxylated polymers, such as hyaluronic acid (HA) and other glycosaminoglycans, 15 and synthetic carboxylated polymers, such as poly(glutamic acid) (PGA), 16 (PAA), 17 and poly(methacrylic acid) (PMA). 18 These polymers have received significant attention for their potential applications in biomedical research due to their biocompatibility, adequate blood circulation half-life, and limited cellular uptake.…”

Section: ■ Introductionmentioning

confidence: 99%

Hydrophobicity Regulates the Cellular Interaction of Cyanine5-Labeled Poly(3-hydroxypropionate)-Based Comb Polymers

et al. 2022

View full text Add to dashboard Cite

An in-depth understanding of the effect of physicochemical properties of nanocarriers on their cellular uptake and fate is crucial for the development of novel delivery systems. In this study, well-defined hydrophobic carboxylated poly(3-hydroxypropionate)-based comb polymers were synthesized. Two oligo(3-hydroxypropionate) (HP n ) of different degrees of polymerization (DP; 5 and 9) bearing α-vinyl end-groups were obtained by an hydrogen transfer polymerization (HTP)-liquid/liquid extraction strategy. 2-Carboxyethyl acrylate (CEA), representing the DP 1 analogue of HP n , was also included in the study. (Macro)monomers were polymerized via reversible addition–fragmentation chain-transfer (RAFT) polymerization and fully characterized by 1H NMR spectroscopy and size exclusion chromatography. All polymers were non-hemolytic and non-cytotoxic against NIH/3T3 cells. Detailed cellular association and uptake studies of Cy5-labeled polymers by flow cytometry and confocal laser scanning microscopy (CLSM) revealed that the carboxylated water-soluble PCEA, the polymer with the shortest side chain, efficiently targets mitochondria. However, increasing the side-chain DP led to a change in the intracellular fate. P(HP5) was trafficked to both mitochondria and lysosomes, while P(HP9) was exclusively found in lysosomes. Importantly, FLIM-FRET investigation of P(HP5) provided initial insight into the mitochondria subcompartment location of Cy5-labeled carboxylated polymers. Moreover, intracellular uptake mechanism studies were performed. Blocking scavenger receptors by dextran sulfate or cooling cells to 4 °C significantly affected the cell association of hydrophobic carboxylated polymers with an insignificant response to membrane-potential inhibitors. In contrast, water-soluble carboxylated polymers’ cellular association was substantially inhibited in cells treated with compounds depleting the mitochondrial potential (ΔΨ). Overall, this study highlights hydrophobicity as a valuable means to tune the cellular interaction of carboxylated polymers and thus will inform the design of future drug carriers based on Cy5-modified carboxylated polymers.

show abstract

Poly(acrylic acid) nanocomposites: Design of advanced materials

Cited by 30 publications

References 94 publications

Chitosan-Grafted Polyacrylic Acid-Doped Copper Oxide Nanoflakes Used as a Potential Dye Degrader and Antibacterial Agent: In Silico Molecular Docking Analysis

Chitosan-Grafted Polyacrylic Acid-Doped Copper Oxide Nanoflakes Used as a Potential Dye Degrader and Antibacterial Agent: In Silico Molecular Docking Analysis

Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications

Hydrophobicity Regulates the Cellular Interaction of Cyanine5-Labeled Poly(3-hydroxypropionate)-Based Comb Polymers

Contact Info

Product

Resources

About