Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery

Abstract

The aim of this study was to develop a stomach-specific drug delivery system to increase the efficacy of amoxicillin against Helicobacter pylori. Polyacrylic acid (PAA), chitosan (CS), and amoxicillin (A) were employed to obtain polyionic complexes. The design of the hydrogel delivery system was based on the swellable approach; with a floating feature to prolong the Gastric Residence Time (GRT). The polyionic complex (PAA:CS:A 2.5:5:2) showed a sustained drug release profile in enzyme-free simulated gastric fluid (SGF) and pH 4.0. A pH independent swelling-eroding pattern with adequate maximum swelling ratios of 17.76 and 13.42 was obtained at in SGF and pH 4.0, respectively, with similar eroding profiles in both pH media. This network carrier provides an amoxicillin protective effect towards the hydrolytic degradation in SGF. The in vivo study was performed on healthy volunteers, using the [ 13 C] octanoic acid breath test. The proposed hydrogel showed a prolonged GRT of up to 3 h. The preliminary results from this study suggest that amoxicillin polyionic complexes have potential for improving local antibiotic therapy against H. pylori.

Bovine serum albumin release from novel chitosan-fluoro-aluminosilicate glass ionomer cement: Stability and cytotoxicity studies

“…Many studies have postulated that the interpolymer complex based on poly (acrylic acid) and chitosan can generate polyionic complexes 13 with different porous structures and can be used to prolong drug delivery. 12,24 Because chitosan is a naturally biodegradable polymer, 25 it might be possible that the release rate of BSA, as the dispersed active agent in this study, may be influenced by the rate of diffusion and also from degradation. However, the total amount of BSA that can be released from this new material for 2 weeks is only about 1.19% of the total BSA that was added, so the residual protein might be entrapped in the polymer network.…”

“…10 Many studies have shown that the interpolymer complex from the reaction of poly (acrylic acid) and chitosan can generate polyionic complexes, which can be used to prolong drug delivery. [11][12][13] Chitosan (CS) is a deacetylation product of chitin, a high molecular weight natural polymer found in shells of marine crustaceans and cell walls of fungi. Chitosan is a co-polymer of glucosamine and N-acetyl-D-glucosamine.…”

Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

“…Consequently the amount of initiator added also greatly affects the molecular weight with a higher initial initiator concentration resulting in a higher concentration of initiator radicals and therefore multiple competing polymerisation events and a lower final molecular weight ( Figure 5). 48 This effect is more pronounce at the higher temperatures evaluated as the initiator half-life time is shorter and so the systematic changes in starting initiator concentration are seen more significantly. The final parameter that impacts the molecular weight is the monomer feed concentration.…”

Measurement of gastric emptying by octanoate metabolism

“…Other pharmaceutical applications have included the assessment of gastric retentive systems for the stomach-specific drug delivery of antibiotics [39,40]. Both studies successfully demonstrated prolonged emptying of the gastric retentive dose forms when compared with conventional dose forms.…”