Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous iron

Putra, N.E.; Tigrine, Ali; Aksakal, Suzan; Rosa, Victor Retamero De La; Taheri, Peyman; Fratila‐Apachitei, Lidy E.; Mol, J.M.C.; Zhou, Jie; Zadpoor, Amir A.

doi:10.1016/j.msec.2021.112617

Cited by 8 publications

(7 citation statements)

References 67 publications

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“…Therefore, the findings from the SEM images also confirm that the PEtOx NPs are digestible in SLF at pH 7.4. However, the PEtOx polymer itself is not digestible in the lung fluids and retains its stability for a long time, which also matches previous findings [61].…”

Section: Morphology Studies By Scanning Electron Microscopy (Sem)supporting

confidence: 91%

“…The PEtOx powder did not produce new peaks at the end of 6 weeks, indicating that the polymer might not be digestible in lung fluids. Similar stable FTIR spectra were also reported by Putra et al [61] when they used PEtOx as the coating of the additively manufactured biodegradable porous iron. Although the layer significantly enhanced the porous iron's biodegradation rate, the polymer remained stable for 28 days.…”

Section: Petox Polymer Digestionsupporting

confidence: 84%

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Cytotoxic and Bactericidal Effects of Inhalable Ciprofloxacin-Loaded Poly(2-ethyl-2-oxazoline) Nanoparticles with Traces of Zinc Oxide

Sabuj

Huygens

Spann

et al. 2023

IJMS

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The bactericidal effects of inhalable ciprofloxacin (CIP) loaded-poly(2-ethyl-2-oxazoline) (PEtOx) nanoparticles (NPs) with traces of zinc oxide (ZnO) were investigated against clinical strains of the respiratory pathogens Staphylococcus aureus and Pseudomonas aeruginosa. CIP-loaded PEtOx NPs retained their bactericidal activity within the formulations compared to free CIP drugs against these two pathogens, and bactericidal effects were enhanced with the inclusion of ZnO. PEtOx polymer and ZnO NPs did not show bactericidal activity alone or in combination against these pathogens. The formulations were tested to determine the cytotoxic and proinflammatory effects on airway epithelial cells derived from healthy donors (NHBE), donors with chronic obstructive pulmonary disease (COPD, DHBE), and a cell line derived from adults with cystic fibrosis (CFBE41o-) and macrophages from healthy adult controls (HCs), and those with either COPD or CF. NHBE cells demonstrated maximum cell viability (66%) against CIP-loaded PEtOx NPs with the half maximal inhibitory concentration (IC50) value of 50.7 mg/mL. CIP-loaded PEtOx NPs were more toxic to epithelial cells from donors with respiratory diseases than NHBEs, with respective IC50 values of 0.103 mg/mL for DHBEs and 0.514 mg/mL for CFBE41o- cells. However, high concentrations of CIP-loaded PEtOx NPs were toxic to macrophages, with respective IC50 values of 0.002 mg/mL for HC macrophages and 0.021 mg/mL for CF-like macrophages. PEtOx NPs, ZnO NPs, and ZnO-PEtOx NPs with no drug were not cytotoxic to any cells investigated. The in vitro digestibility of PEtOx and its NPs was investigated in simulated lung fluid (SLF) (pH 7.4). The analysed samples were characterized using Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and UV–Vis spectroscopy. Digestion of PEtOx NPs commenced one week following incubation and was completely digested after four weeks; however, the original PEtOx was not digested after six weeks of incubation. The outcome of this study revealed that PEtOx polymer could be considered an efficient drug delivery carrier in respiratory linings, and CIP-loaded PEtOx NPs with traces of ZnO could be a promising addition to inhalable treatments against resistant bacteria with reduced toxicity.

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Section: Morphology Studies By Scanning Electron Microscopy (Sem)supporting

confidence: 91%

Section: Petox Polymer Digestionsupporting

confidence: 84%

Cytotoxic and Bactericidal Effects of Inhalable Ciprofloxacin-Loaded Poly(2-ethyl-2-oxazoline) Nanoparticles with Traces of Zinc Oxide

Sabuj

Huygens

Spann

et al. 2023

IJMS

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“…33,34 PEOx is a tertiary polyamide, and it has been widely studied since it shows similar hydrophilicity to PEG and balanced amphiphilicity, demonstrating potential applications in tissue regeneration and drug delivery systems. 35 As previously pointed out, the objective of this work is to prepare porous poly(m-phenylene isophthalamide) films using these polymers as porosity promoters in an inexpensive and simple way without impairing their performance, establishing relationships between the porosity former and the properties of the films. The obtention of porous highperformance polymers with controlled pore morphology and outstanding properties plays a key role in the development of separators for ion lithium batteries, [36][37][38][39][40] or osmosis membranes.…”

Section: Methodsmentioning

confidence: 99%

“…PVA possesses a number of hydroxyl groups in its structure, as well as CA, providing many interactive sites to form hydrogen bonds with amide groups in aramids 33,34 . PEOx is a tertiary polyamide, and it has been widely studied since it shows similar hydrophilicity to PEG and balanced amphiphilicity, demonstrating potential applications in tissue regeneration and drug delivery systems 35 …”

Section: Introductionmentioning

confidence: 99%

Preparation of low‐density high‐performance porous aramid films using porosity promoter polymers

Rubio‐Aguinaga

Ruiz

Muñoz

et al. 2022

J of Applied Polymer Sci

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Low-density porous aramid films using inexpensive and widely available polymers as porosity promoters, that is, polyvinyl alcohol (PVA), poly(2-ethyl-2-oxazoline) (PEOx), and cellulose polyacetate (CA) were fabricated. Porous poly (m-phenylene isophthalamide) films were obtained by the standard casting procedure using mixtures of the aramid with either PVA, PEOx, or CA, followed by the removal of the porosity promoter polymers by immersing them in water or acetone. As a result, films with up to a 65% density reduction with pore sizes ranging from 0.02 to 10 μm and up to 30% increment in Young's modulus were obtained. In addition, the morphology of the films was homogeneous and was controlled by the proportion and nature of the porosity promoter polymer. The density reduction of materials plays a significant role in energy crises and the need for fuel reduction. This study revealed that it is possible to prepare low-density porous aramid films inexpensively without impairing their outstanding performance by using PVA in the casting procedure as a porosity promoter polymer.

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“…Furthermore, the respective strong double peaks at 2874, 2933 and 2974 are attributed to alkane -CH 2 -stretching and bending groups [45,46]. The OH bonding at 3484 cm − 1 on the PEtOx hydrogel was attributed to the hydroxyl terminated feature of the hydrogel [47]. The band at 1428 cm − 1 was attributed to CH 3 bending groups [48].…”

Section: Ftir Analysismentioning

confidence: 99%

The Synergistic Effect of Biochar and Poly(2-ethyl-2-oxazoline)/poly(2- hydroxyethylmethacarylate)/Chitosan) Hydrogels on Saline Soil Properties and Carrot Productivity

Abdeen

Hefni

Awadallah‐F

et al. 2023

Preprint

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Background Soil Salinity is one of the most important factors limiting crop production. Moreover, with the increasing population and saline soil worldwide there is no choice but to use saline soil to increase the agricultural area. Therefore, to increase carrot productivity under saline conditions, it's necessary to provide good management such as applying hydrogels and biochar for improving soil properties. Methodology Hydrogels (PEtOx-HEMA-CS) were prepared from poly (2-ethyl-2-oxazoline), chitosan (CS), and 2-hydroxyethyl methacrylate (HEMA as crosslinker), by exposure those to gamma irradiation at range from 0–50 kGy with 0.9 kGy/h, and obtained three types of hydrogels according to concentration of chitosan. The PEtOx-HEMA-CS hydrogels were prepared for enhanced water holding capacity for agriculture purposes. The chemical structures of those were investigated by FTIR, XRD and SEM. Biochar (BC) as an active substance was physically mixed with those hydrogels at different ratios (0/100, 0.5/99.5, 1/99 and 100/0 (g/g) biochar/hydrogels). BC, PEtOx-HEMA-CS and the mixture of PEtOx-HEMA-CS-BC were mixed with saline soil at ratio 0.05 and 0.1% w/w of prepared materials/soil. Pot agriculture carrot experiments were conducted to mitigate the salinity hazards by using biochar with and without hydrogels. Findings The obtained data referred that there is a significant decrease in soil salinity and exchangeable sodium percentage and increase in organic matter, cation exchange capacity, field capacity, permanent wilting point and available water especially at (PEtOx-HEMA-CS5)0.1-BC1. The highest increment percentage of NP and K were 36.36, 70 and 72%, respectively. Also, the relative increase of carrot productivity was 49.63% at the highest rates of biochar and hydrogels. However, the highest value of water use efficiency was observed at the mixture of biochar and hydrogels at (PEtOx-HEMA-CS5)0.1-BC1. Conclusion Finally, applying biochar combined with (PEtOx-HEMA-CS5) could be recommended as a good approach to enhance carrot productivity and water use efficiency under saline soil conditions.

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Poly(2-ethyl-2-oxazoline) coating of additively manufactured biodegradable porous iron

Cited by 8 publications

References 67 publications

Cytotoxic and Bactericidal Effects of Inhalable Ciprofloxacin-Loaded Poly(2-ethyl-2-oxazoline) Nanoparticles with Traces of Zinc Oxide

Cytotoxic and Bactericidal Effects of Inhalable Ciprofloxacin-Loaded Poly(2-ethyl-2-oxazoline) Nanoparticles with Traces of Zinc Oxide

Preparation of low‐density high‐performance porous aramid films using porosity promoter polymers

The Synergistic Effect of Biochar and Poly(2-ethyl-2-oxazoline)/poly(2- hydroxyethylmethacarylate)/Chitosan) Hydrogels on Saline Soil Properties and Carrot Productivity

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