Abstract:RESUMO -
INTRODUÇÃOEm nossas viagens anuais às reservas indíge-nas Xavantes de Sangradouro e São Marcos, observamos seis casos com um mesmo quadro clínico de fraqueza progressiva, emagrecimento progressivo, perda da massa muscular e dificuldade motora. Dos seis casos observados, dois ocorreram em Sangradouro, um dos quais evoluiu para caquexia e morte e o outro faz parte deste nosso relatório; quatro ocorreram em São Marcos, um dos quais faz parte deste relatório, outros dois evoluíram para caquexia e morte, o… Show more
“…O primeiro estudo que investigou a ocorrência de diabetes mellitus ocorreu em 1975 com indígenas do Norte do Pará, não sendo encontrado nenhum caso 9 . Em 1977, os indígenas do Norte do Amapá foram avaliados, e 1% dos indivíduos apresentou diabetes mellitus 10 . Na aldeia Jaguapiru, localizada no Município de Dourados, Mato Grosso do Sul, Região Centro-oeste do Brasil, um estudo realizado entre 2007 e 2008 detectou que 6,8% das mulheres possuíam diabetes mellitus 11 .…”
Section: No Modelo Linear Generalizado Permaneceram Associadas No Munclassified
Resumo: O objetivo do estudo foi estimar a prevalência de glicemia capilar casual alterada, sugestiva de diabetes mellitus, e sua associação com os fatores socioeconômicos, demográficos, antropométricos e clínicos em mulheres indígenas do Município de Dourados, Mato Grosso do Sul, Brasil. Trata-se de um estudo transversal, com amostra probabilística composta por mulheres de 18-59 anos, residentes nas aldeias Bororó e Jaguapiru. Foi utilizado um questionário padronizado para a coleta das informações, e a análise estatística, realizada por meio dos testes Kruskal Wallis, Mann Whitney e do modelo linear generalizado. Entre as 385 mulheres, 7% apresentaram glicemia capilar casual alterada sugestiva de diabetes mellitus. No modelo linear generalizado, permaneceram associadas, no modelo final, as variáveis idade (p < 0,001), pressão arterial sistólica (p = 0,002) e etnia (p = 0,022). Este estudo demonstra a necessidade de mudanças comportamentais, com o auxílio de intervenções educativas como estratégia de prevenção e controle do diabetes mellitus.
“…O primeiro estudo que investigou a ocorrência de diabetes mellitus ocorreu em 1975 com indígenas do Norte do Pará, não sendo encontrado nenhum caso 9 . Em 1977, os indígenas do Norte do Amapá foram avaliados, e 1% dos indivíduos apresentou diabetes mellitus 10 . Na aldeia Jaguapiru, localizada no Município de Dourados, Mato Grosso do Sul, Região Centro-oeste do Brasil, um estudo realizado entre 2007 e 2008 detectou que 6,8% das mulheres possuíam diabetes mellitus 11 .…”
Section: No Modelo Linear Generalizado Permaneceram Associadas No Munclassified
Resumo: O objetivo do estudo foi estimar a prevalência de glicemia capilar casual alterada, sugestiva de diabetes mellitus, e sua associação com os fatores socioeconômicos, demográficos, antropométricos e clínicos em mulheres indígenas do Município de Dourados, Mato Grosso do Sul, Brasil. Trata-se de um estudo transversal, com amostra probabilística composta por mulheres de 18-59 anos, residentes nas aldeias Bororó e Jaguapiru. Foi utilizado um questionário padronizado para a coleta das informações, e a análise estatística, realizada por meio dos testes Kruskal Wallis, Mann Whitney e do modelo linear generalizado. Entre as 385 mulheres, 7% apresentaram glicemia capilar casual alterada sugestiva de diabetes mellitus. No modelo linear generalizado, permaneceram associadas, no modelo final, as variáveis idade (p < 0,001), pressão arterial sistólica (p = 0,002) e etnia (p = 0,022). Este estudo demonstra a necessidade de mudanças comportamentais, com o auxílio de intervenções educativas como estratégia de prevenção e controle do diabetes mellitus.
“…No Brasil, quadro semelhante tem sido observado em estudos realizados na última década e que incluíram um componente sobre consumo alimentar (Lima, 2004;Ribas & Phillippi, 2003;Santos et al, 1997;Schuch, 2001). Um exemplo drástico das implicações nutricionais desse tipo de mudança é representado pelo caso Xavánte, onde recentemente foram registrados casos de béri-béri, alguns evoluindo para o óbito -em decorrência de uma dieta extremamente monótona e baseada no arroz polido (Vieira-Filho et al, 1997).…”
“…We wonder if Xikrin working habits could contribute to the disease. An interesting observation of Werneck et al 11 and Vieira-Filho 12 drives us to a few hypothesis. In Werneck´s report, statistical relationships were found between heavy occupations, such as agricultural, forestery and fishery workers, and males with ALS 11 .…”
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confidence: 91%
“…The absence of family history and no other patient in his tribe with ALS does not give us a hint of a possible mechanism to explain the development of disease in this unique ethnic group. A previous report of Vieira-Filho and coworkers 12 showed two Brazilian natives of the Xavantes group who developed polyneuropathy related initially to thiamin deficiency. In their report, the authors identified that the consume, almost exclusively, of manufactured rice, poor in thiamine, contributed to development of this polyneuropathy.…”
mentioning
confidence: 93%
“…In native communities men are responsible for hunting and agriculture such as reported by Vieira-Filho and coworkers 4 . On the other hand, women have a hard occupation in agriculture, hand craft and taking care of children 12 . More specific association of ALS with different occupation have appeared in some casecontrol studies.…”
Amyotrophic lateral sclerosis (ALS) is one of the major neurodegenerative disorders alongside Alzheimer's disease and Parkinson's disease. It is a progressive disorder that involves degeneration of motor system at all levels, leading to muscle weakness and fatal course. Physical signs of this disease thus encompass both upper and lower motor neurons.The former is characterized by brisk reflexes and signs of pyramidal release such as Babinski sign, and the latter by muscle atrophy and fasciculation 1 . The diagnostic criteria for ALS were published elsewhere 2 . The incidence of sporadic ALS is between 1.5-2/ 100000 per year, giving a prevalence of around 6/100000. Males are usually more affected than females (ratio 1.6:1) 1 . In Brazil, an attempt to put together a comprehensive database to assess ALS's epidemiological aspects was performed. The incidence and prevalence were lower than in Europe and USA. Regarding the clinical characteristics the same clinical pattern as in European and North-American patients was found. Minor differences in Brazilian patients were found on their lower age at onset and a higher incidence of bulbar onset among women 3 . Several causal and pathogenic hypotheses for ALS have been proposed over the years, ranging from genetic to environmental etiology. Approximately 5-10% patients with the diagnosis of ALS present a positive family history. Autosomal recessive and dominant pattern of inheritance were already described. Between 10-20% of autosomal-dominant patients have mutations in superoxide dismuatse (SOD1) gene on chromosome 21. Numerous other genetic mutations were reported: angiogenin (14q11.2), vascular endothelial growth factor (6p12), survival motor neuron (5q12.2-q13.3), neurofilament protein (22q12.2), and charged multivesicular body protein 2B (2p11.2) 4 . A host of environmental factors have been investigated as potential risk factors, ranging from heavy-metal toxic effects to occupational exposures. Current research are focusing largely on excitotoxicity and oxidative stress, even the cycad exposure has been revisited 5,6 . Chomorros, a native population of Guam Island, were the first group in which a clear environmental toxin exposure was related to increased risk of ALS 6 . In Brazil, there is no description of a native group with increased risk of ALS.Herein we describe the first report of ALS in a Brazilian native of the Xikrin group. This group of natives belongs to a larger group known as Kayapó from "Jê" linguistic family. Their village extends along the Cateté river, in eastern Amazonia, State of Para, north of Brazil. The Xikrin were almost extinct by 1968, reaching the number of only 98 7 . However, in the last four decades, with an appropriate health support, their population has been increasing due to a great number of births and reduction in infantile mortality, reaching a total population of 947 natives (512 male and 435 female) in July 2007 8 . Figure shows Xikrin village during a traditional ritual for old and young men.
CASeA 46-year-old female Xikrin...
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