Polarographic and voltammetric behaviour of ofloxacin and its analytical application

Ge-rong, Zhou; Pan, Jing-Hao

doi:10.1016/0003-2670(95)00028-x

Cited by 55 publications

(19 citation statements)

References 14 publications

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“…160,161 Several conventional anticancer drugs with autofluorescence often have tunable fluorescence when coordinating with central metal atoms. 162,163 ICP-type nanomedicines are believed to be suitable candidates for computational design and combinatorial chemistry for drug content-specific nanomedicine development, because of their high drug-loading content and efficiency. 164 This section outlines recent advances in ICP I-type high drugloading nanomedicines that consist of metal atoms and two kinds of organic ligands, with one of the ligands being the drug molecule.…”

Section: Icp I-type Nanomedicinesmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

423

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Icp I-type Nanomedicinesmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

423

268

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“…However, in spite of their high selectivity and sensitivities, these techniques are time-consuming, require complex sample procedures and involve the use of large amounts of reagents and organic solvents thus incurring in considerable costs. Other alternatives described include spectrophotometric [21][22][23], fluorimetric [24][25][26], chemiluminesce [27][28][29], voltammetric [30][31][32], and immunoassay [33] methodologies. Most of them present several disadvantages such as use of expensive equipment, inadequate selectivity, requirement of long sample pretreatment or even complex treatment of the analytical results.…”

Section: Introductionmentioning

confidence: 99%

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

et al. 2011

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An ofloxacin-selective electrode was developed for application in pharmaceutical preparations, serum and urine analysis. The electrode is based on tetrakis[3,5-bis(trifluoromethyl)phenyl]borate as ion exchanger in a poly(vinyl chloride) membrane. The sensor displayed a Nernstian response for ofloxacin over a wide concentration range (3 10) with a slope of 55 AE 1 mV per decade of concentration and a practical detection limit of 1 10 À6 mol L À1. The electrode was successfully applied to the determination of ofloxacin in samples with no pretreatment steps, adequate accuracy and precision and recoveries within the intervals of 94-107 %.

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“…HPLC has been used for the assay of OFX in pharmaceuticals when present either alone [5][6][7] or in combination with nitazoxanide [8]. Various other techniques including HPTLC [9], capillary electrophoresis [10,11], atomic absorption spectrometry [12], spectrofluorometry [12], chemiluminescence spectrometry [13][14][15], UV-spectrophotometry [16][17][18], stripping voltammetry [19], potentiometry and conductometry [20], polarography [21], and microbiological method [22] have been reported for the assay of OFX in pharmaceuticals. Many of the above techniques are deficient on simplicity, cost-effectiveness, and easy accessibility.…”

Section: Introductionmentioning

confidence: 99%

Simple and Selective Spectrophotometric Determination of Ofloxacin in Pharmaceutical Formulations Using Two Sulphonphthalein Acid Dyes

2013

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Two new simple and sensitive extraction-free spectrophotometric methods have been established for the determination of ofloxacin (OFX). The methods are based on ion-pair complex formation reaction between OFX and acidic sulphonphthalein dyes, bromocresol purple (method A), and bromocresol green (method B) in dichloromethane. The experimental variables such as reaction medium, reaction time, and reagent concentration have been carefully optimized to achieve the highest sensitivity. Both dyes react spontaneously with OFX to give yellow-colored complexes. Beer's law is obeyed over the concentration ranges of 1.0-16 g ml . The limits of detection (LOD) and quantification (LOQ) are also reported. A Job's plot of the absorbance versus the molar ratio of OFX to each of dyes under consideration indicated (1 : 1) ratio and the conditional stability constant ( ) of the complexes have been calculated. The proposed methods were applied successfully to the determination of OFX in tablets with good accuracy and precision and without interference from common additives. The results obtained by the proposed methods were compared favorably with those of the reference method.

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Polarographic and voltammetric behaviour of ofloxacin and its analytical application

Cited by 55 publications

References 14 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

Determination of Ofloxacin in Pharmaceuticals, Human Urine and Serum Using a Potentiometric Sensor

Simple and Selective Spectrophotometric Determination of Ofloxacin in Pharmaceutical Formulations Using Two Sulphonphthalein Acid Dyes

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