Poison Oak Hyposensitization

Protective Effect of DetoxifiedRhus vernicifluaStokes on Human Keratinocytes and Dermal Fibroblasts against Oxidative Stress and Identification of the Bioactive Phenolics

“…15,16) Despite these studies, the application of RVS as a food additive or source of pharmaceutical ingredients has been limited, because urushiol derivatives in RVS are known to cause irritation, inflammation or blistering in sensitive individuals, a reaction known as urushiolinduced contact dermatitis. 17) For this reason, research has been focused on removing urushiol derivatives from RSV by heat treatment, solvent extraction, far-infrared radiation, and enzyme treatment. 18) Nevertheless, little information is available on the health effects of detoxified R. verniciflua Stokes (DRVS) devoid of urushiol.…”

Kontaktallergie auf Poison ivy ( Toxicodendron spp.)

“…Neben der Aufklärung der Bevölkerung (v. a. Erkennen der Pflanzen) werden Barriereschutzpräparate eingesetzt [7,9,21]. Eine Hyposensibilisierung wird kontrovers diskutiert [5,6,9,20,21,24].Als Nebenwirkungen sind Pruritus ani und ausgeprägte kutane Reaktionen bekannt.…”

Immunologic (Allergic) Contact Dermatitis*

“…In the United States, poison oak/ivy is the single most common cause of C.D. At least half the population is clinically sensitive and attempts to prevent the dermatitis by immunological means have thus far proved relatively unsuccessful (46,47). Utilizing a modified cytotoxicity assay, developed for the study of human cancers (48) we have begun to develop in vitro methods to investigate poison oak/ivy sensitization and tolerization in vitro.…”