Point-of-need detection of microcystin-LR using a smartphone-controlled electrochemical analyzer

Guan, Tian; Huang, Wenzheng; Xu, Ningxia; Xu, Zhenzhen; Jiang, Lelun; Li, Mengting; Wei, Xiaoqun; Liu, Yingju; Shen, Xing; Li, Xiangmei; Yi, Changqing; Lei, Hongtao

doi:10.1016/j.snb.2019.05.028

Cited by 43 publications

(15 citation statements)

References 46 publications

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Section: Resultsmentioning

confidence: 99%

“…These types of applications are extremely different in terms of the variety of chemical structures to be analyzed (samples) and the functionality of the smartphone application used to process the samples. [161][162][163][164][165][166][167] Imaging techniques are not popular in this category, as the adapter consists of special electronics that are designed specifically to target a unique chemical compound. [168][169][170][171][172][173][174] Using a smartphone proved to be cost effective (see Figure 12), and extremely accurate results were reported when comparing the performance of the smartphone-based adapters to those of laboratory equipment and devices with a low CV%, a high regression coefficient, lower costs, and a low LOD (see Figures 10 to 13).…”

Section: Electrochemical Applicationsmentioning

confidence: 99%

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A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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In this review, we explore the potential of smartphone‐based applications based on their unique ability to support portable, easy‐to‐use, precise, and efficient functions, which, in turn, makes lab‐on‐hardware a trending area of novel research. Smartphones can assist surgeons, physicians, biologists, chemists, ophthalmologists, and laboratory technicians in maintaining an easy‐to‐use, cost‐effective, and integrated environment for treatment, diagnosis, and point‐of‐care (POC) applications. These POC applications can improve patients' quality of life, offering patients a precise diagnosis and the correct treatment. This is a noble goal that aims to reduce costs and to increase the accuracy of sample testing, treatment, and diagnosis. Recent innovations have made major advances in smartphone adapters, providing portability, robustness, self‐powered devices, small‐sized adapters, and ease of usage. Lab‐on‐hardware is a progressing field, and smartphone imaging applications are increasingly expanding, resulting in POC applications with the latest and most advanced image analysis, enhancement, recognition, and other image processing techniques. The most recent studies in the field are explored to provide a solid background to interested researchers against which they can choose of application and/or adapter design they aim to develop, with a discussion of the methods reviewed here.

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Section: Resultsmentioning

confidence: 99%

Section: Electrochemical Applicationsmentioning

confidence: 99%

A review of smartphone point‐of‐care adapter design

Alawsi

Al-Bawi

2019

Engineering Reports

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“…Thus, their overall score is 3.1, still placing them in the top 3 most promising portable food analyzers, along with paper-based and smartphone-based optical food analyzers. While smartphone-based electrochemical devices have been developed for medical diagnostics and environmental analysis, there are very few examples of smartphone-based electrochemical biosensors for food safety testing [ 127 , 128 , 129 , 130 , 131 ].…”

Section: Portable Electrochemical Food Analyzersmentioning

confidence: 99%

ASSURED Point-of-Need Food Safety Screening: A Critical Assessment of Portable Food Analyzers

Jafari

Guercetti

Geballa-Koukoula

et al. 2021

Foods

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Standard methods for chemical food safety testing in official laboratories rely largely on liquid or gas chromatography coupled with mass spectrometry. Although these methods are considered the gold standard for quantitative confirmatory analysis, they require sampling, transferring the samples to a central laboratory to be tested by highly trained personnel, and the use of expensive equipment. Therefore, there is an increasing demand for portable and handheld devices to provide rapid, efficient, and on-site screening of food contaminants. Recent technological advancements in the field include smartphone-based, microfluidic chip-based, and paper-based devices integrated with electrochemical and optical biosensing platforms. Furthermore, the potential application of portable mass spectrometers in food testing might bring the confirmatory analysis from the laboratory to the field in the future. Although such systems open new promising possibilities for portable food testing, few of these devices are commercially available. To understand why barriers remain, portable food analyzers reported in the literature over the last ten years were reviewed. To this end, the analytical performance of these devices and the extent they match the World Health Organization benchmark for diagnostic tests, i.e., the Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end-users (ASSURED) criteria, was evaluated critically. A five-star scoring system was used to assess their potential to be implemented as food safety testing systems. The main findings highlight the need for concentrated efforts towards combining the best features of different technologies, to bridge technological gaps and meet commercialization requirements.

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“…Microcystins, produced by cyanobacteria in a water environment, belong to cyclic heptapeptide group toxins [ 164 ]. This is the most toxic and common variant among different microcystin congeners and is considered as a great threat to human health, which can lead to liver damage and even tumor promotion through the consumption of polluted food products and drinking water [ 165 , 166 ].…”

Section: Analytes For Nucleic Acids Aptamers In the Modern Medicalmentioning

confidence: 99%

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

Ziółkowski

Jarczewska

Górski

et al. 2021

Sensors

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This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.

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Point-of-need detection of microcystin-LR using a smartphone-controlled electrochemical analyzer

Cited by 43 publications

References 46 publications

A review of smartphone point‐of‐care adapter design

A review of smartphone point‐of‐care adapter design

ASSURED Point-of-Need Food Safety Screening: A Critical Assessment of Portable Food Analyzers

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

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