Point-of-Care for Evaluating Antimicrobial Resistance through the Adoption of Functional Materials

Singh, Sima; Numan, Arshid; Cinti, Stefano

doi:10.1021/acs.analchem.1c03856

Cited by 33 publications

(29 citation statements)

References 168 publications

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“…51 Using the SWASV approach, Hwang et al coupled the biocompatibility of chitosan and Fe to design a composite modified sensor to detect As(III) in mine wastewater and soil leachate. SPCE without chitosan-Fe modification had a surface area of 0.0105 cm 2 and SPCE with chitosan-Fe modification had a surface area of 0.17769 cm 2 , respectively. The result shows that the electrode surface can be increased by the composite modification process.…”

Section: Modification Of Printing Ink To Improve the Sensitivity Of Spesmentioning

confidence: 99%

“…1 Yet, despite its fundamental reach, current traditional techniques have been constrained within the blocks of a laboratory because of their instrumental sophistication and overpriced, limiting external application in low-resource settings, making them bot suitable for in situ and point-of-care (POC) solutions. 2 One of the major areas of interest for both centralized and non-centralized analysis is the development of portable systems and the reduction of sample volume. And this interest is fulfilled by combination of electrochemical techniques with screen printed electrodes (SPEs).…”

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confidence: 99%

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Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors

2022

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Portability is one of the essential keys in the development of modern analytical devices. Screen printing technology is an established technology for both chemical and biosensor development. Screen printing technology has been used to generate a variety of electronic sensors that are rapid, cost-effective, on-site, real-time, inexpensive, and practical for use in healthcare, environmental monitoring, industrial monitoring, and agricultural monitoring. This review aims to describe recent research progress related to the development and improvement of screen-printed electrodes (SPEs). We also demonstrate the wide range of applications, also highlighting the market directions and the need for novel devices to be used by non-specialists. Finally, we conclude and provide an overview of the constraints and future opportunities of SPEs in biosensor application.

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Section: Modification Of Printing Ink To Improve the Sensitivity Of Spesmentioning

confidence: 99%

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confidence: 99%

Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors

2022

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“…Antibiotics, which are used in treating diseases that affect both humans and animals, are commonly shown to be ineffective due to the rapidly increasing antimicrobial resistance (AMR). 8 Then, the effectiveness of antibiotics is slowly decreasing, challenging current research on the design of innovative antimicrobial therapies. 9 Antibiotic-resistant bacteria are a major problem worldwide.…”

Section: Introductionmentioning

confidence: 99%

Site-Specific Evaluation of Bioactive Coumarin-Loaded Dendrimer G4 Nanoparticles against Methicillin Resistant Staphylococcus aureus

et al. 2022

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Methicillin-resistant Staphylococcus aureus (MRSA) is a foremost treatment challenge in today’s clinical practice. Natural coumarins contain a variety of bioactivities and have the ability to alter resistance in several ways. In developing effective drug delivery methods, the goal is to maximize biocompatibility while minimizing toxicity. With this in mind, this work investigated the site-specific potential of dendrimer G4 poloxamer nanoparticles loaded with bioactive coumarin. The goal of the current work is to deliver a complete evaluation of dendrimer G4 poloxamer nanoparticles against MRSA. Coumarin-loaded dendrimer G4 poloxamer nanoparticles were thoroughly investigated and characterized using various techniques, including particle size, shape, entrapment efficiency, in vitro drug release, hemolysis assay, cytotoxicity, antibacterial activity, and bactericidal kinetics. Studies showed that the newly developed dendrimer G4 poloxamer nanoparticles exhibited significantly lower levels of hemolysis and cytotoxicity. The results showed that the in vitro drug release of coumarin from dendrimer G4 poloxamer nanoparticles was slower compared to coumarin in its free form. This innovative therapeutic delivery technology may enhance the defense of coumarin against MRSA.

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“…It is portable and allows point-of-care testing (POCT) to perform real-time monitoring of the analyte of interest. 33 Fluorescence platforms rely on on/off fluorescence signals and wavelength shifts with overlapping fluorescence pairs. Fluorescence detection may have a low detection limit due to the limited extinction coefficients and labeling ratios of organic dyes.…”

Section: Introductionmentioning

confidence: 99%

“…Fluorescence-based techniques are widely used in trace detection, biological imaging, diagnostics, optoelectronics, and forensics because they represent simple and ubiquitous analytical approaches. , With its fast response time, low false alarm rate, low cost, and realistic temperature range, it provides “naked eye” detection with contrast and versatility. It is portable and allows point-of-care testing (POCT) to perform real-time monitoring of the analyte of interest . Fluorescence platforms rely on on/off fluorescence signals and wavelength shifts with overlapping fluorescence pairs.…”

Section: Introductionmentioning

confidence: 99%

Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

et al. 2022

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Efficient and simple detection of chemical warfare agents (CWAs) is an essential step in minimizing the potentially lethal consequences of chemical weapons. CWAs are a family of organic chemicals that are used as chemical weapons because of their enormous severity and lethal effects when faced with unforeseen challenges. To stop the spread of CWAs, it is critical to develop a platform that detects them in a sensitive, timely, selective, and minimally invasive manner. Rapid advances in the demand for on-site sensors, metal nanoparticles, and biomarker identification for CWAs have made it possible to use fluorescence as a precise real-time and point-of-care (POCT) testing technique. For POCT-based applications, the new capabilities of micro- and nanomotors offer enormous prospects. In recent decades, significant progress has been made in the design of fluorescent sensors and the further development of noble metal nanoparticles for the detection of organophosphorus CWAs, as described in this review. Through this work, recent attempts to fabricate sensors that can detect organophosphorus CWAs through changes in their fluorescence properties have been summarized. Finally, an integrated outlook on how noble metal nanoparticles could be used to develop smart sensors for organophosphorus CWAs that communicate with and control electronic devices to monitor and improve the health of individuals.

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Point-of-Care for Evaluating Antimicrobial Resistance through the Adoption of Functional Materials

Cited by 33 publications

References 168 publications

Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors

Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors

Site-Specific Evaluation of Bioactive Coumarin-Loaded Dendrimer G4 Nanoparticles against Methicillin Resistant Staphylococcus aureus

Advances in Noble-Metal Nanoparticle-Based Fluorescence Detection of Organophosphorus Chemical Warfare Agents

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