Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

Abstract

S. pneumoniae infection remains a serious public health concern despite the availability of vaccines covering up to 23 of more than 94 known serotypes. The purpose of the present study was to monitor recent serotype distribution data. PubMed, EMBASE, Cochrane Reviews and Ingenta databases were searched. Serotype data covering invasive pneumococcal disease (IPD) and non-IPD were extracted from

Direct and indirect impact of 10-valent pneumococcal conjugate vaccine introduction on pneumonia hospitalizations and economic burden in all age-groups in Brazil: A time-series analysis

“…There is also scarce data on which serotypes are responsible for the pneumococcal pneumonias. However, there seems to be an indication that, differently from children, in which the majority of serotypes causing IPD are covered by PCV10, there is a greater diversity in serotypes causing IPD in adults with 50 years and more [ 47 ]. As a result, PCV10 vaccination of children may not be affecting at least a proportion of the serotypes causing pneumonia in the elderly.…”

Clinical Relevance and Molecular Pathogenesis of the Emerging Serotypes 22F and 33F of Streptococcus pneumoniae in Spain

“…The effectiveness of current pneumococcal conjugate vaccines against targeted serotypes has been very successful decreasing the burden of disease caused by these serotypes, although unfortunately some countries have reported an increase of IPD cases by certain non-vaccine types in recent years (Feikin et al, 2013;Savulescu et al, 2017;Ladhani et al, 2018;Lewnard and Hanage, 2019). This is the case for serotypes 22F and 33F with different countries reporting increased rates in children and adults after PCV13 (Kaplan et al, 2013;Pichon et al, 2013;Moore et al, 2015;Golden et al, 2016;Balsells et al, 2017;Cui et al, 2017). Serotypes 22F and 33F are also important in terms of quality adjusted life years (QALY) as they caused the highest QALY loss among non-PCV13 serotypes in children (van Hoek et al, 2012).…”

Glomerulonefritis infecciosa y pleuroneumonía por Streptococcus pneumoniae. Caso clínico pediátrico

“…12 También, referente al desarrollo de infección invasora por neumococo, los serotipos 6C y 16F han sido los más prevalentes entre aquellos no incluidos en vacunas en población norteamericana y africana. 13 Con la introducción de la vacuna 13-valente, se cubre la cepa 19A, la cual es la más frecuentemente asociada al desarrollo de SHU por neumococo. 6 No obstante, la cepa 6C no se encuentra presente en las vacunas antineumocócicas disponibles en la actualidad.…”