2002
DOI: 10.1034/j.1600-051x.2002.290613.x
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PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase‐alpha‐1‐proteinase inhibitor complex

Abstract: The clinical healing in chronic periodontal disease is associated with a downregulation of the local PMN responses following periodontal therapy. The reorganization of periodontal tissues is characterized by a decrease of lysosomal enzyme activities and the alpha-1-proteinase inhibitor complex in gingival crevicular fluid.

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Cited by 39 publications
(41 citation statements)
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“…It can be argued that as PMNs are loaded with proteolytic enzymes that are capable of causing liquefaction of the soft tissue, a special, nonredundant pathway of clearance has been developed to effectively clear aging PMNs before the cell membrane integrity is compromised and the damaging proteases are released. In humans, under physiological conditions such a mechanism in conjunction with other pathways of clearance acts to remove 10 11 PMNs daily.…”
Section: Discussionmentioning
confidence: 99%
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“…It can be argued that as PMNs are loaded with proteolytic enzymes that are capable of causing liquefaction of the soft tissue, a special, nonredundant pathway of clearance has been developed to effectively clear aging PMNs before the cell membrane integrity is compromised and the damaging proteases are released. In humans, under physiological conditions such a mechanism in conjunction with other pathways of clearance acts to remove 10 11 PMNs daily.…”
Section: Discussionmentioning
confidence: 99%
“…This scenario fits very well into the clinical picture of adult onset of periodontal disease where high levels of proteolytic activity, both PMN and P. gingivalis derived, are present in the gingival exudates together with large numbers of necrotic PMNs. 11,15,44 Thus, periodontitis can be considered as another example of inflammatory disease caused by proteinase-induced dysfunctional clearance of apoptotic cells.…”
Section: Discussionmentioning
confidence: 99%
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“…Protein hidrolizinin ve hücre lizisinin bir belirteci olarak, artmış seviyeleri periodontal doku yıkımının son aşamasını gös-terir. 65 Katepsin D'nin temel görevi, hücre içi ve hücre dışından hücre içine alınan proteinlerin lizozomlarda parçalanmasıdır. 66,67 İnflame dokuda yüksek konsantrasyonlarda bulunur.…”
Section: Katepsi̇nlerunclassified
“…(33) and were expressed as mmol/L. Also, Nitric oxide was determined as described previously by Vodovotz (34) and Myeloperoxidase was quantified spectrophotometrically by the method described by Buchmann et al (35). However, Antioxidant status was studied by glutathione (GSH), glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD), Arylesterase (AE) and Paraoxonase (PON).…”
Section: Measurement Of Oxidative Stress Markers and Anti-oxidant Statusmentioning
confidence: 99%