PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase‐alpha‐1‐proteinase inhibitor complex

Buchmann, Rainer; Hasilík, Andrej; Nunn, Martha E.; Dyke, Thomas E. Van; Lange, Dieter

doi:10.1034/j.1600-051x.2002.290613.x

Cited by 39 publications

(41 citation statements)

References 49 publications

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“…It can be argued that as PMNs are loaded with proteolytic enzymes that are capable of causing liquefaction of the soft tissue, a special, nonredundant pathway of clearance has been developed to effectively clear aging PMNs before the cell membrane integrity is compromised and the damaging proteases are released. In humans, under physiological conditions such a mechanism in conjunction with other pathways of clearance acts to remove 10 11 PMNs daily.…”

Section: Discussionmentioning

confidence: 99%

“…This scenario fits very well into the clinical picture of adult onset of periodontal disease where high levels of proteolytic activity, both PMN and P. gingivalis derived, are present in the gingival exudates together with large numbers of necrotic PMNs. 11,15,44 Thus, periodontitis can be considered as another example of inflammatory disease caused by proteinase-induced dysfunctional clearance of apoptotic cells.…”

Section: Discussionmentioning

confidence: 99%

“…10 However, it has also been well documented that tissue damage associated with periodontal disease is related to extensive accumulation of PMNs and the release of their destructive hydrolytic enzymes. [11][12][13] In this context, it is interesting to note that large number of PMNs in gingival crevicular fluid are found at different stages of necrosis. 14,15 This may indicate that either the apoptotic program or clearance pathways of dying PMNs are malfunctioning at periodontal sites.…”

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confidence: 99%

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A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages

et al. 2006

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The recognition of phosphatidylserine (PS) on the surface of any apoptotic cell is considered to be a key event for its clearance. We challenge this concept by showing that pretreatment of neutrophils with either host or bacterial protease affects their uptake by human monocyte-derived macrophages without having an effect on cell-surface PS presentation. Specifically, whereas preincubation of apoptotic neutrophils with cathepsin G or thrombin significantly inhibited their uptake, gingipains R or clostripain enhanced phagocytosis by macrophages. Moreover, bacterial proteinases sensitized healthy neutrophils for uptake by macrophages, whereas endogenous proteinases were unable to elicit this effect. This stimulation was apparently owing to the combined effect of proteolytic cleavage of an antiphagocytic signal (CD31) and the generation of a novel 'eat-me' signal on the neutrophil surface. These results argue that neutrophil recognition and phagocytosis by macrophages is mediated by a protein ligand whose proteolytic modification could affect the local inflammatory process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages

et al. 2006

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“…Protein hidrolizinin ve hücre lizisinin bir belirteci olarak, artmış seviyeleri periodontal doku yıkımının son aşamasını gös-terir. 65 Katepsin D'nin temel görevi, hücre içi ve hücre dışından hücre içine alınan proteinlerin lizozomlarda parçalanmasıdır. 66,67 İnflame dokuda yüksek konsantrasyonlarda bulunur.…”

Section: Katepsi̇nlerunclassified

Host Derived Enzymes in Gingival Crevicular Fluid as a Periodontal Diagnostic Biomarker-Part 1: Review

Göktürk¹,

Turkal²,

Yarkaç³

et al. 2016

Turkiye Klinikleri J Dental Sci

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“…(33) and were expressed as mmol/L. Also, Nitric oxide was determined as described previously by Vodovotz (34) and Myeloperoxidase was quantified spectrophotometrically by the method described by Buchmann et al (35). However, Antioxidant status was studied by glutathione (GSH), glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD), Arylesterase (AE) and Paraoxonase (PON).…”

Section: Measurement Of Oxidative Stress Markers and Anti-oxidant Statusmentioning

confidence: 99%

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

Al-Jiffri

2016

Electron J Gen Med

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Objective: As oxidative status may be an influential factor for increasing the progress of the disease and decreasing the effectiveness of the treatment, the aim of this study was to measure the oxidative stress and anti-oxidative markers among Saudi patients with chronic hepatitis C (CHC) versus nonalcoholic steatohepatitis (NASH). Methods: This study was carried out on a sample of 150 consecutive patients (75 with CHC and 75 with NASH), selected from gastroenterology outpatient clinic, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Also, this study included 75 healthy volunteers, mostly, relatives of the patients who came with them to the clinic. Measurements of oxidative stress and anti-oxidative stress markers were measured for all participants. Results:The mean values of oxidative stress markers included conjugated dienes (CD), malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) were significantly elevated in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly elevated in patients with NASH than patients with CHC. However, the mean values of anti-oxidative stress markers include glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH), arylesterase (AE) and paraoxonase (PON) were significantly reduced in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly reduced in patients with NASH than patients with CHC. Conclusion: In this study, patients with NASH have higher levels of oxidative and lower anti-oxidant markers than patients with CHCs.

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PMN responses in chronic periodontal disease: evaluation by gingival crevicular fluid enzymes and elastase‐alpha‐1‐proteinase inhibitor complex

Cited by 39 publications

References 49 publications

A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages

A new insight into phagocytosis of apoptotic cells: proteolytic enzymes divert the recognition and clearance of polymorphonuclear leukocytes by macrophages

Host Derived Enzymes in Gingival Crevicular Fluid as a Periodontal Diagnostic Biomarker-Part 1: Review

Oxidative stress biomarkers among Saudi patients with non-alcoholic steatohepatitis versus chronic hepatitis C

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