PLMA-b-POEGMA Amphiphilic Block Copolymers as Nanocarriers for the Encapsulation of Magnetic Nanoparticles and Indomethacin

Abstract

Abstract:We report here on the utilization of poly(lauryl methacrylate)-b-poly(oligo ethylene glycol methacrylate) (PLMA-b-POEGMA) amphiphilic block copolymers, which form compound micelles in aqueous solutions, as nanocarriers for the encapsulation of either magnetic iron oxide nanoparticles or iron oxide nanoparticles, and the model hydrophobic drug indomethacin in the their hydrophobic core. The mixed nanostructures were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM) in terms of their structure and solution properties. Magnetophoresis experiments showed that the mixed solutions maintain the magnetic properties of the initial iron oxide nanoparticles. Results indicate that the cumulative hydrophilic/hydrophobic balance of all components determines the colloidal stability of the nanosystems. The effect of salt and bovine serum albumin (BSA) protein concentration on the structure of the mixed nanostructures was also investigated. Disintegration of the mixed nanostructures was observed in both cases, showing the importance of these parameters in the structure formation and stability of such complex mixed nanosystems.

Synthesis of doxorubicin‐loaded PBMA‐b‐POEGMA micelles and assessment of its anticancer activity against breast cancer cells (4T1)

“…There are many studies in this field that confirm the potential and function of the micellar structures for anticancer drug delivery 29–31 . In this regard, some monomers such as HEMA (2‐hydroxyethyl methacrylate), LMA (lauryl methacrylate), MMA (Methyl methacrylate), BMA (n‐butyl methacrylate), and OEGMA (Oligo ethylene glycol methyl ether methacrylate) can be suitable options for the synthesis of AmBCs due to hydrophilic/hydrophobic and biocompatible characters which are resulted from their side chains 24,32–34 …”

Amphiphilic P(OEGMA-co-DIPAEMA) Hyperbranched Copolymer/Magnetic Nanoparticle Hybrid Nanostructures by Co-Assembly

“…Therefore, they are being extensively developed and constructed due to their multi-functionality for the cure of various life-threatening diseases. A wide range of research has been reported to procure the effectiveness of such materials in theranostic applications [1][2][3][4][5][6][7][8][9]. Polymer nanomedicine is based on the development of copolymers that are biodegradable and biocompatible, and provides bioavailability and colloidal stability to the formed multifunctional hybrid nanomaterials and entrapped species.…”

Poly[oligo(ethylene glycol) methacrylate]-b-poly[(vinyl benzyl trimethylammonium chloride)] Based Multifunctional Hybrid Nanostructures Encapsulating Magnetic Nanoparticles and DNA

“…Magnetic nanoparticles (MNPs) have been used in a multitude of biomedical applications including magnetic resonance imaging (as negative contrast agents), gene therapy, targeted drug delivery, and magnetic hyperthermia treatment (under alternating magnetic fields) [ 22 , 23 , 24 , 25 , 26 ], rendering them ideal for the design of hybrid nanostructures based on polymers.…”