Amphiphilic P(OEGMA-co-DIPAEMA) Hyperbranched Copolymer/Magnetic Nanoparticle Hybrid Nanostructures by Co-Assembly

Abstract

This work presents the utilization of amphiphilic poly(oligo(ethylene glycol) methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched (HB) copolymers, forming polymeric aggregates in aqueous media, as building nanocomponents and nanocarriers for the entrapment of magnetic cobalt ferrite nanoparticles (CoFe2O4, MNPs), and the hydrophobic drug curcumin (CUR) in their hydrophobic domains. Dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM) techniques were used to evaluate the multifunctional hybrid nanostructures formed in aqueous media by co-assembly of the components and their solution properties. Magnetic nanoparticles (MNPs) or MNPs/CUR were co-assembled effectively with pre-existing polymer aggregates, leading to well-defined hybrid nanostructures. Magnetophoresis experiments revealed that the hybrid nanostructures retain the magnetic properties of MNPs after their co-assembly with the hyperbranched copolymers. The hybrid nanostructures demonstrate a significant colloidal stability under physiological conditions. Furthermore, MNPs/CUR-loaded aggregates displayed considerable fluorescence as demonstrated by fluorescence spectroscopy. These hybrid nanostructures could be promising candidates for drug delivery and bio-imaging applications.

Novel Multi-Responsive Hyperbranched Polyelectrolyte Polyplexes as Potential Gene Delivery Vectors

“…In addition, some interesting characteristics of hyperbranched copolymers are their low-level viscosity as well as their compact conformations because of their hyperbranched structure. These characteristics make hyperbranched copolymers a potential platform for a wide range of biomedical applications, such as drug [ 33 , 34 , 35 ] and gene delivery [ 36 , 37 , 38 ], as well as tissue engineering [ 39 , 40 , 41 ].…”

Thermo- and pH-responsive poly[(diethylene glycol methyl ether methacrylate)-co-(2-diisopropylamino ethyl methacrylate)] hyperbranched copolymers: self-assembly and drug-loading

“…6,7 Hyperbranched polymers compared to the corresponding linear polymers have the ability to self-assemble in more dense conformations in aqueous solutions. 8 These characteristics are attracting interest for a range of biomedical applications, 9 such as in drug 10–12 and gene delivery 13,14 and tissue engineering. 15,16…”

“…6,7 Hyperbranched polymers compared to the corresponding linear polymers have the ability to self-assemble in more dense conformations in aqueous solutions. 8 These characteristics are attracting interest for a range of biomedical applications, 9 such as in drug [10][11][12] and gene delivery 13,14 and tissue engineering. 15,16 In recent years, polymer-based nanomedicine has focused on functional polymeric materials that respond to physical and chemical stimuli such as temperature, [17][18][19] pH 20,21 and ionic strength.…”

Sulfonated Block Copolymers: Synthesis, Chemical Modification, Self-Assembly Morphologies, and Recent Applications

“…The growing interest in ABCs lies in the advantages that are obtained from the hybrid materials to form nanostructures with unique properties. This may include applications that require colloidal solubility, interface activity, stabilization of dispersed particles, and ionic conductivity for application such as fuel and solar cells [ 12 ], drug delivery systems [ 11 , 13 ], and nanomanufacturing of electronic devices [ 20 , 21 , 22 , 23 ].…”