Thermo- and pH-responsive poly[(diethylene glycol methyl ether methacrylate)-<i>co</i>-(2-diisopropylamino ethyl methacrylate)] hyperbranched copolymers: self-assembly and drug-loading

Selianitis, Dimitriοs; Pispas, Stergios

doi:10.1039/d2py01447e

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…On the contrary, the change from an acidic to an almost neutral pH, slightly alkaline, was illustrated by smaller-sized DSPC:DOPC configurations with larger mass. The more compact aggregates due to pH change have been mentioned before for PDIPAEMA nanostructures [68]. Despite the different physicochemical results, in all cases the decrease in hydrophilicity of the copolymer due to partial deprotonation of the amine group as well as hydration repulsions and osmotic phenomena due to the existence of PBS ions are the driving forces for the rearrangement of the molecules to different structures [51,73].…”

Section: The Impact Of Stimuli-responsive Copolymers On the Physicoch...mentioning

confidence: 56%

“…In general, the mass of colloidal systems based on intensity values shows fluctuations in a similar manner to particle size [52]. The increase in the dimensions of DSPC:DOPC hybrid systems could be linked to a swollen structure due to the protonated amino group carrying segments that are fully stretched, in accordance with PDIPAEMA behavior in other nanoparticles [68]. The opposite results of DSPC hybrid systems evince different interactions according to extended DLVO theory [51].…”

Section: The Impact Of Stimuli-responsive Copolymers On the Physicoch...mentioning

confidence: 82%

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Development of Hybrid DSPC:DOPC:P(OEGMA950-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter

et al. 2023

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Hybrid nanoparticles have gained a lot of attention due to their advantageous properties and versatility in pharmaceutical applications. In this perspective, the formation of novel systems and the exploration of their characteristics not only from a physicochemical but also from a biophysical perspective could promote the development of new nanoplatforms with well-defined features. In the current work, lipid/copolymer bilayers were formed in different lipid to copolymer ratios and examined via differential scanning calorimetry as a preformulation study to decipher the interactions between the biomaterials, followed by nanostructure preparation by the thin-film hydration method. Physicochemical and toxicological evaluations were conducted utilizing light scattering techniques, fluorescence spectroscopy, and MTS assay. 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in different weight ratios were the chosen lipids, while a linear random copolymer with pH- and thermoresponsive properties comprised of oligo (ethylene glycol) methyl ether methacrylate (OEGMA) and 2-(diisopropylamino) ethyl methacrylate (DIPAEMA) in different ratios was used. According to our results, non-toxic hybrid nanosystems with stimuli-responsive properties were successfully formulated, and the main parameters influencing their overall performance were the hydrophilic/hydrophobic balance, lipid to polymer ratio, and more importantly the random copolymer topology. Hopefully, this investigation can promote a better understanding of the factors affecting the behavior of hybrid systems.

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Section: The Impact Of Stimuli-responsive Copolymers On the Physicoch...mentioning

confidence: 56%

Section: The Impact Of Stimuli-responsive Copolymers On the Physicoch...mentioning

confidence: 82%

Development of Hybrid DSPC:DOPC:P(OEGMA950-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter

et al. 2023

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Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery

Guo,

He,

Williams

et al. 2024

Journal of Pharmaceutical Analysis

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Unveiling the Performance of Co-Assembled Hybrid Nanocarriers: Moving towards the Formation of a Multifunctional Lipid/Random Copolymer Nanoplatform

Triantafyllopoulou,

Perinelli,

Forys

et al. 2024

Pharmaceutics

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Despite the appealing properties of random copolymers, the use of these biomaterials in association with phospholipids is still limited, as several aspects of their performance have not been investigated. The aim of this work is the formulation of lipid/random copolymer platforms and the comprehensive study of their features by multiple advanced characterization techniques. Both biomaterials are amphiphilic, including two phospholipids (1,2-dioctadecanoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)) and a statistical copolymer of oligo (ethylene glycol) methyl ether methacrylate (OEGMA) and 2-(diisopropylamino) ethyl methacrylate (DIPAEMA). We examined the design parameters, including the lipid composition, the % comonomer ratio, and the lipid-to-polymer ratio that could be critical for their behavior. The structures were also probed in different conditions. To the best of the authors’ knowledge, this is the first time that P(OEGMA-co-DIPAEMA)/lipid hybrid colloidal dispersions have been investigated from a membrane mechanics, biophysical, and morphological perspective. Among other parameters, the copolymer architecture and the hydrophilic to hydrophobic balance are deemed fundamental parameters for the biomaterial co-assembly, having an impact on the membrane’s fluidity, morphology, and thermodynamics. Exploiting their unique characteristics, the most promising candidates were utilized for methotrexate (MTX) loading to explore their encapsulation capability and potential antitumor efficacy in vitro in various cell lines.

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Thermo- and pH-responsive poly[(diethylene glycol methyl ether methacrylate)-co-(2-diisopropylamino ethyl methacrylate)] hyperbranched copolymers: self-assembly and drug-loading

Abstract: We present the synthesis of a new series of thermo- and pH-responsive poly[(diethylene glycol methyl ether methacrylate)-co-(2-diisopropylamino ethyl methacrylate)], P(DEGMA-co-DIPAEMA), hyperbranched copolymers and studies regarding their self-assembly in aqueous media....

Cited by 3 publications

References 52 publications

Development of Hybrid DSPC:DOPC:P(OEGMA950-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter

Development of Hybrid DSPC:DOPC:P(OEGMA950-DIPAEMA) Nanostructures: The Random Architecture of Polymeric Guest as a Key Design Parameter

Tumor microenvironment-responsive hyperbranched polymers for controlled drug delivery

Unveiling the Performance of Co-Assembled Hybrid Nanocarriers: Moving towards the Formation of a Multifunctional Lipid/Random Copolymer Nanoplatform

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