PLGA: a Unique Polymer for Drug Delivery

Kapoor, Deepak; Bhatia, Amit; Kaur, Ripandeep; Sharma, Ruchi; Kaur, Gurpreet; Dhawan, Sanju

doi:10.4155/tde.14.91

Cited by 479 publications

(326 citation statements)

References 118 publications

Supporting

Mentioning

296

Contrasting

Unclassified

Order By: Relevance

“…Unlike LA and GA, PLGA is characterized to be soluble in several solvents, including tetrahydrofuran, dichloromethane, chloroform, ethyl acetate, hexafluoroisopropanol, acetone, and benzyl alcohol. [29] This solubility though, is described to decrease with the increase in the GA content. [13a] Similarly, the glass transition temperature (T g ) of PLGA is also correlated with its LA:GA proportions.…”

Section: Physical-chemical Propertiesmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

205

133

View full text Add to dashboard Cite

Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

show abstract

Section: Physical-chemical Propertiesmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

205

133

View full text Add to dashboard Cite

show abstract

“…[28][29][30][31] In recent years, with the advent of block copolymers, the use of PLGA in the development of controlled and targeted drug delivery systems has substantially increased. 32 The attractive features of PLGA-based NPs, such as their small size, high structural integrity, stability, ease of fabrication, tunable properties, controlled-release capabilities, and surface functionalization characteristics, make them versatile therapeutic delivery vehicles.…”

Section: Discussionmentioning

confidence: 99%

Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis

Liu¹,

Xu²,

Zhou³

et al. 2017

IJN

View full text Add to dashboard Cite

Thrombotic disease is a great threat to human health, and early detection is particularly important. Magnetic resonance (MR) molecular imaging provides noninvasive imaging with the potential for early disease diagnosis. In this study, we developed Fe 3 O 4 -based poly(lactic- co -glycolic acid) (PLGA) nanoparticles (NPs) surface-modified with a cyclic Arg-Gly-Asp (cRGD) peptide as an MR contrast agent for the detection of thrombosis. The physical and chemical characteristics, biological toxicity, ability to target thrombi, and biodistribution of the NPs were studied. The Fe 3 O 4 -PLGA-cRGD NPs were constructed successfully, and hematologic and pathologic assays indicated no in vivo toxicity of the NPs. In a rat model of FeCl 3 -induced abdominal aorta thrombosis, the NPs readily and selectively accumulated on the surface of the thrombosis and under vascular endothelial cells ex vivo and in vivo. In the in vivo experiment, the biodistribution of the NPs suggested that the NPs might be internalized by the macrophages of the reticuloendothelial system in the liver and the spleen. The T2 signal decreased at the mural thrombus 10 min after injection and then gradually increased until 50 min. These results suggest that the NPs are suitable for in vivo molecular imaging of thrombosis under high shear stress conditions and represent a very promising MR contrast agent for sensitive and specific detection of thrombosis.

show abstract

“…Furthermore, PLGA can be formulated as nanoparticles using several different methods, such as solvent displacement, solvent diffusion, emulsification–evaporation, and phase-inversion; with sizes ranging from 10 to 1000 nm. PLGA nanoparticles have been incorporated into gels using hydroxypropyl methylcellulose (HPMC) or Carbopol® to further enhance the penetration of drugs [38] into the deeper layers of the skin by increasing contact time with the skin and reducing the loss of water from the skin.…”

Section: Nanoparticles For Topical Therapymentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

443

227

View full text Add to dashboard Cite

This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

show abstract

PLGA: a Unique Polymer for Drug Delivery

Cited by 479 publications

References 118 publications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Fe<sub>3</sub>O<sub>4</sub>-based PLGA nanoparticles as MR contrast agents for the detection of thrombosis

Nanoparticles and nanofibers for topical drug delivery

Contact Info

Product

Resources

About