Pleomorphic liposarcoma: A cytologic study of five cases

Abstract

Pleomorphic liposarcoma represents one of the rarest variants of liposarcoma. It has a poor prognosis and unlike other variants of liposarcoma, lacks a molecular or genetic signature. Histologic studies of pleomorphic liposarcoma have defined this lesion as a high grade sarcoma, which contains a variable number of lipoblasts. We describe the cytologic features of five cases of pleomorphic liposarcoma, all of which had histologic confirmation. We consistently identified numerous lipoblasts as well as micro and macrovesicular fat vacuoles in the background of cellular, pleomorphic sarcomatoid neoplasms. The appearance of the aspirates differs substantially form other variants of liposarcoma.

Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis

“…10 Unlike the other subtypes of liposarcoma, the pleomorphic variant is unique in that it lacks a molecular signature, thus making it difficult to diagnose. 33 It also is often reported to be high grade and may even resemble de-differentiated morphologically. The pleomorphic subtype had the highest proportion of high-grade cases in the SEER database (Grades III & IV ¼ 86.4%), which is similar to other studies.…”

Large retroperitoneal soft tissue tumor: A cytopathological diagnosis

“…Well-differentiated and dedifferentiated liposarcomas show amplification of Murine double minute 2 homolog (MDM 2) and CDK4 genes. [ 6 7 8 9 ] These molecular alterations help in distinguishing well-differentiated liposarcoma from benign adipose tumors and dedifferentiated liposarcomas from other poorly differentiated sarcomas. Myxoid liposarcoma shows DNA damage - inducible transcript 3 (DD1T3) rearrangements.…”

“…Myxoid liposarcoma shows DNA damage - inducible transcript 3 (DD1T3) rearrangements. [ 6 7 8 9 ] PLS comprise only 5% of all liposarcoma, do not show any specific aberration, and can be differentiated from myxofibrosarcoma only by the presence of pleomorphic lipoblasts. [ 6 ] However, molecular studies in the present case could not be done due to unavailability and financial constraints.…”

“…The application of adjuvant chemotherapy has been tried in many research centers. [ 7 ] PLS has a propensity for recurrence and metastasis. [ 8 ] Recurrence rate of 15%–36% has been noted in numerous studies over a period of 10–30 years of follow-up.…”

<p>Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic Significance</p>

“… 2 WDLPS are low-grade tumors with more moderate behavior, whereas DDLPS, MLPS and PLPS are high-grade tumors with greater aggressiveness, recurrence and metastasis potential. 3 – 5 At present, surgical resection is still the only method to cure RLPS; however, surgical resection cannot resolve the problem of local recurrence and often becomes not applicable for advanced-stage patients. In addition, different subtypes of liposarcoma have heterogeneous biological behaviors and inconsistent responses to radiotherapy and chemotherapy.…”