OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth
factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral
maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age
range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood
samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on
lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and
cervical staging data of 30 female subjects were included and taken from records
of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test.
Bonferroni correction was carried out and alpha value was set at 0.003. RESULTS: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4
in males. Differences between males and females were observed in mean values of
IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed
in CS4 followed by CS5 and third highest in CS3; whereas in females the highest
mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5.
Trends of IGF-1 in relation to the cervical stages also differed between males and
females. The greatest mean serum IGF-1 value for both sexes was comparable, for
females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). CONCLUSIONS: Males and females showed differences in IGF-1 trends and levels at different
cervical stages.
FNA is a relatively reliable, safe and quick method of diagnosing pulmonary infection in immunocompromised patients. Cytomorphological features, when aided by special stains, can accurately detect the specific infection which is potentially treatable. Specific infections may be suggested based on specific imaging patterns.
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