Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis

Amer, Kamil; Congiusta, Dominick V.; Thomson, Jennifer E.; Elsamna, Samer T.; Chaudhry, Iftikhar M.; Bozzo, Anthony; Amer, Rami; Siracuse, Brianna L.; Ghert, Michelle; Beebe, Kathleen S.

doi:10.1016/j.jcot.2020.04.013

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…A recent large database analysis from United States and Canada also showed similar results; WDLS was the most common histology, with a high 5-year OS rate of 82%, followed by 76% for MLS, 63% for mixed tumors, 55% for round cell, 51% for PLS, and 49% for DDLS. 10 Our findings are consistent with these data, except for the extremely poor prognosis of PLS in our series but there were only four patients with PLS. The principal treatment modality for STS is still surgery.…”

Section: Discussionsupporting

confidence: 92%

Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience

Demir

Güven

Aktaş

et al. 2022

South Asian J Cancer

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Objective Liposarcomas are relatively rare tumors. Prognostic and predictive factors and treatment options are limited. We herein presented our 10-year experience with liposarcomas. Materials and Methods Adult patients with liposarcoma treated between 2005 and 2015 in our center were included. Demographic and clinicopathologic features of patients were retrieved from patient files. Statistical Analyses Outcomes in terms of disease-free survival (DFS) and overall survival (OS) were assessed along with potential prognostic factors using Kaplan–Meier analyses. Results A total of 88 patients were included. The median age was 52. Rates of well-differentiated (WDLS), dedifferentiated (DDLS), myxoid (MLS), and pleomorphic liposarcomas (PLS) were 42, 9.1, 37.5, and 4.5%, respectively. Only 10% of patients had high-grade tumors and 93% had localized disease. Ninety-six percent of patients (n = 84) underwent surgery. Adjuvant chemotherapy was delivered to 16 patients. The most common regimen was ifosfamide–doxorubicin. Recurrences were observed in 30 patients, 21 had local, and 9 had distant metastasis. Five-year DFS of patients with the localized disease was 68%. All patients with PLS had relapses and those had the highest distant relapse rates among all subtypes. Multivariate analysis showed T stage and grade were associated with DFS. Five-year OS of the entire population was 68%. Five-year OS was 79, 76, 50, and 0% in WDLS, MLS, DDLS, and PLS, respectively (p = 0.002). Conclusion Management of liposarcomas is still challenging. Surgery is the mainstay of treatment. Novel effective therapies are needed, particularly in advanced disease settings.

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Section: Discussionsupporting

confidence: 92%

Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience

Demir

Güven

Aktaş

et al. 2022

South Asian J Cancer

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“…Furthermore, the prognosis of sarcomas depends more strongly on the histological type than the mitotic status and necrosis. 15 Moreover, advances in genetic searches have led to advances in the diagnosis of sarcomas. However, the use of the FNCLCC classification is controversial, and a new system for grading the histological malignancy of RPS is required.…”

Section: Clinicopathological Gradingmentioning

confidence: 99%

Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review

Yamagata,

Komiyama,

Iwata

2023

Annals of Gastroent Surgery

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Retroperitoneal sarcoma (RPS) is a rare tumor classified into many histological types. It is also often detected only after it has grown to a considerable size and requires extensive resection of the surrounding organs, making it difficult to offer optimal patient‐tailored management. Evidence supporting specific treatment modalities for RPS is insufficient, owing to its rarity. The Japanese clinical practice guidelines for RPS were published in December 2021, with the aim of accumulating existing evidence and indicating the optimal practice for RPS. These guidelines provide important clinical questions (CQs) concerning the diagnosis and treatment of RPS. This review, with a particular focus on primary RPS, attempts to introduce clinical problems in the diagnosis and treatment of RPS and to assess those problems along with the CQs in the guidelines. According to these guidelines, although chemotherapy and radiotherapy are expected to have therapeutic effects, the level of evidence to support these treatments is not very high at present. Accordingly, complete resection of the tumor is the first and only option for managing primary RPS. However, as with other tumors, the demand for multidisciplinary treatment for RPS is increasing. These guidelines will undoubtedly represent a milestone in clinical practice in relation to RPS in the future, and further evidence is expected to be accumulated based on the CQs that have been proposed.

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“…Several factors influence the prognosis of RLPS and are summarized in Table 1 . It is commonly recognized that the two most important predictors of local recurrence (LR) and disease-specific survival (DSS) are complete surgical resection and histological grade ( Amer et al, 2020 ; Matthyssens et al, 2015 ; Singer et al, 2003 ; Tyler et al, 2020 ; Vijay & Ram, 2015 ; Wu et al, 2018 ; Zhao et al, 2015 ). Complete resection with negative microscopic margins (R0) is the optimal surgical outcome ( Keung et al, 2014 ; Vijay & Ram, 2015 ; Zhao et al, 2015 ).…”

Section: Literature Reviewmentioning

confidence: 99%

“…Bold indicates exclusive to subtype. Information from Amer et al (2020) ; Cancer Genome Atlas Research Network (2017) ; Creytens et al (2015) ; Trautmann et al (2019) ; Tyler et al (2020) .…”

Section: Literature Reviewmentioning

confidence: 99%

Retroperitoneal Liposarcoma: An Unusual Presentation of a Rare Cancer

Spicer¹,

Ma²,

Pa-C³

2021

JADPRO

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Retroperitoneal liposarcomas (RLPS) are rare tumors that have variable clinical behavior and complex treatment strategies based on presentation, histopathology, and genomics. Early identification is critical, and complete surgical resection remains the primary treatment, although chemotherapy and radiation are used on individual bases. Presenting symptoms are often nonspecific; therefore, a high degree of suspicion is essential for early diagnosis. In this report, the management of a 37-year-old otherwise healthy male with a large RLPS causing right groin/testicular pain is presented. After three evaluations in the emergency department, the patient was diagnosed and received two cycles of doxorubicin/ifosfamide/mesna (AIM) neoadjuvant chemotherapy. His physical exam on presentation for second opinion demonstrated a large palpable abdominal mass and fullness around the right spermatic cord. There was no appreciable change in tumor size or distant metastases on repeat scanning. Given some obstructive symptoms, a multidisciplinary team advised neoadjuvant radiation followed by radical resection of RLPS. Final pathology demonstrated a 31-cm grade II well-differentiated (WD) liposarcoma with low-grade dedifferentiation. Scattered foci of microscopic positive WD margins were noted, and the remainder of margins were negative. Genomic evaluation showed amplification of CDK4, MDM2, and FRS2. A concise literature review of common presentations, histopathology, genomics, and treatment information is discussed herein. Thorough physical exams, attention to subtle findings, appropriate medical imaging studies, and a high index of suspicion when evaluating vague symptomatology can lead to earlier diagnosis and treatment of RLPS, and ultimately better patient outcomes.

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Epidemiology and survival of liposarcoma and its subtypes: A dual database analysis

Cited by 16 publications

References 32 publications

Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience

Prognosis of Liposarcoma Patients in Modern ERA: Single-Center Experience

Clinical characteristics and management of primary retroperitoneal sarcoma: A literature review

Retroperitoneal Liposarcoma: An Unusual Presentation of a Rare Cancer

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