Pleomorphic adenoma of the eyelid with apocrine gland origin; an atypical location

Rothwell, Renata; Campelos, Sofia; Prazeres, Sandra

doi:10.4103/2008-322x.194144

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…Eyelid lesions that exhibit decapitation secretion have been described in such diverse entities as apocrine tubular adenoma, 3 hidradenoma, 4 pleomorphic adenoma, 5 and adenocarcinoma. 4,6 When decapitation is absent due to chronic hydrostatic pressure within a cyst lumen, the apocrine derivation may be inferred from the presence of the bilayer and supported by the positivity of characteristic immunostains such as GDCFP-15 (Gross Cystic Disease Fluid Protein 15) and CK7.…”

Section: Discussionmentioning

confidence: 99%

Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile

Charles

McGee²,

Kim³

2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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FIG. 3. Postulated mechanism of exogenous ochronosis from Teavigo. Excess of Teavigo competitively inhibits HA oxidase, leading to accumulation of homogentisic acid and its metabolites, ultimately resulting in accumulation of ochronotic pigment in the degraded collagen and elastic fibers. Ha, homogentisic acid.and pathologists should be aware of this entity and a thorough review of medication history should be performed in cases of atypical pigmentation affecting multiple sites of the body such as skin, conjunctiva, sclera, and cartilage.

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Section: Discussionmentioning

confidence: 99%

Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile

Charles

McGee²,

Kim³

2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Follow-up is indicated only if the excision is incomplete which may recur or transform into malignancy, which has been very rarely documented in the literature [12]. Other methods of treatment are electrodessication, dermabrasion, and vaporization with argon or CO 2 laser [13]. For malignant lesions, the initial treatment modality is aggressive surgery followed by adjuvant radiotherapy, with or without chemotherapy [8].…”

Section: Discussionmentioning

confidence: 99%

Chondroid Syringoma of Medial Canthus – A Rare Case Report

Kumar¹,

Sangma²,

Mishra³

et al. 2020

IJCR

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Chondroid syringoma of the skin is a rare, benign skin adnexal tumor, usually exhibited as a slowly growing intradermal or subcutaneous nodule, typically located in the head-and-neck region. Chondroid syringoma usually appears on the face; medial canthus being a rare site of predilection. The diagnosis is usually made retrospectively based on histological features of the surgically excised mass which is usually asymptomatic. We present a rare case of a 35-year-old man who presented with a painless, subcutaneous nodule in the medial canthus of the right eye. The diagnosis of chondroid syringoma was rendered. To the best of our knowledge, only one case of chondroid syringoma of the medial canthus has been documented in the literature. Histopathological examination is mandatory for arriving at the diagnosis. It should be considered in the differential diagnosis of all the slowly growing nodular lesions in the face.

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“…The lesion in our patient demonstrated focal spindle cell stromal proliferation in a myxoid background and squamous metaplasia reminiscent of apocrine variant of pleomorphic adenoma (chondroid syringoma), a rare adnexal neoplasm, which can arise in apocrine sweat glands. Similar to its salivary and lacrimal gland counterpart, the chondroid syringoma is characterized by proliferation of sweat gland ductules suspended in a myxoid, chondroid, adipocytic, or fibrous stroma, 11 which harbors PLAG1 rearrangements in 37–72% of cases 12 . The apocrine variant of chondroid syringoma features glandular epithelial component with apocrine differentiation.…”

Section: Discussionmentioning

confidence: 99%

Tubular apocrine adenoma of the eyelid – A case report and literature review

Eiger-Moscovich

Zhang

Lally

et al. 2019

Saudi Journal of Ophthalmology

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Tubular apocrine adenoma is a rare benign adnexal neoplasm most commonly identified in the scalp, composed of a dermal proliferation of apocrine tubules in a background of hyalinized stroma. Tubular apocrine adenoma can be a component of various sweat gland tumors and can also morphologically overlap with other sweat gland neoplasms. Isolated tubular apocrine adenoma arising in the glands of Moll is exceedingly rare, with only 4 previously reported cases. We present a 63-year-old male with tubular apocrine adenoma of the left upper eyelid, which recurred following initial incomplete excision. Although the lesion showed focal morphologic similarity to the apocrine variant of pleomorphic adenoma (chondroid syringoma), the diagnosis of tubular apocrine adenoma was supported by fluorescence in situ hybridization studies, which demonstrated absence of PLAG1 and HMGA2 gene rearrangements seen in pleomorphic adenoma. This case illustrates the clinical, microscopic and immunohistochemical features of tubular apocrine adenoma. The recent advances in our understanding of the molecular genetics of tubular apocrine adenoma and related tumors, and how these advances shape the evolving classification of sweat gland tumors are reviewed.

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Pleomorphic adenoma of the eyelid with apocrine gland origin; an atypical location

Cited by 8 publications

References 18 publications

Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile

Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile

Chondroid Syringoma of Medial Canthus – A Rare Case Report

Tubular apocrine adenoma of the eyelid – A case report and literature review

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