Apocrine Cystadenoma of the Eyelid, a Rare Neoplasm: Expanded Immunohistologic Profile

Abstract

FIG. 3. Postulated mechanism of exogenous ochronosis from Teavigo. Excess of Teavigo competitively inhibits HA oxidase, leading to accumulation of homogentisic acid and its metabolites, ultimately resulting in accumulation of ochronotic pigment in the degraded collagen and elastic fibers. Ha, homogentisic acid.and pathologists should be aware of this entity and a thorough review of medication history should be performed in cases of atypical pigmentation affecting multiple sites of the body such as skin, conjunctiva, sclera, and cartilage.