Pleomorphic adenoma of nasal septum, an unusual site: a case report from Nepal

Aryal, Gyan Raj; Shrestha, Nischal; Basnet, Meenakshi; Shrestha, Oshan; Sharma, Pratikshya

doi:10.1093/omcr/omac152

Cited by 2 publications

(3 citation statements)

References 10 publications

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“…2023 Jul;11 (7):2739-2741 carcinoma, malignant melanoma, lymphoma, cartilaginous tumors as differential diagnosis. 3 Our case is 65-year female with chronic unilateral nasal obstruction and nasal bleeding in right nasal cavity. Histopathological examination of resected nasal mass revealed the diagnosis of PA. PA is a circumscribed tumor characterized by its pleomorphic or mixed appearance consisting of proliferation of epithelial and spindle shaped myoepithelial cells in variable stroma.…”

Section: Malignant Intranasal Mass Includes Squamous Cellmentioning

confidence: 90%

“…Intranasal PA mostly occur at the age of 30-60 years and the incidence is more common in females. 3 Most common clinical presentation in unilateral nasal obstruction is epistaxis. Other signs and symptoms are nasal mass, epiphora and mucopurulent rhinorrhoea.…”

Section: Case Reportmentioning

confidence: 99%

“…Nasal PA s (0.4%) most often arise from the nasal septum followed by lateral nasal wall. Intranasal PA mostly occur at the age of 30-60 years and the incidence is more common in females 3.…”

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confidence: 99%

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A classic triphasic pleomorphic adenoma of nasal cavity mimicking as malignancy: a rare case report

R¹,

Pavithra²,

Sherin³

et al. 2023

Int J Res Med Sci

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Pleomorphic adenoma (PA) is the most common benign tumor of major salivary glands and intra nasal PA is unusual which may be misdiagnosed as malignancy. A 65-year-old female presented with unilateral nasal bleeding and nasal obstruction in right nasal cavity for 6 months. Local examination showed polypoid mass which surgically excised. HPE showed classic triphasic component of epithelial, myoepithelial with cartilaginous stromal elements and pathological diagnosis of PA made. High cellularity of tumor and predominant squamous epithelial component with keratin pearl created diagnostic confusion of malignancy and it confirmed by immune-histochemistry using p63 to demonstrate presence of myoepithelial component. Highlighted this case report for its unusual location and rare triphasic component of tumor tissue with keratin pearl formation which mimic as malignancy.

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Section: Malignant Intranasal Mass Includes Squamous Cellmentioning

confidence: 90%

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

A classic triphasic pleomorphic adenoma of nasal cavity mimicking as malignancy: a rare case report

R¹,

Pavithra²,

Sherin³

et al. 2023

Int J Res Med Sci

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A Review of the Current Literature on Pleomorphic Adenoma

Kalwaniya¹,

Meena²,

Kumar³

et al. 2023

Cureus

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Pleomorphic adenomas (PA) are the most common benign salivary gland tumors. They arise from the major salivary glands, as well as the minor salivary glands. They may arise rarely from the palate, oral cavity, neck, and nasal cavity also. Yet, the fourth, fifth, and sixth decades of life are the most common for them to manifest. Forty percent of them occur in males and 60% in females. It is a benign mixed tumor, which has three components: an epithelial component, a myoepithelial cell component, and a mesenchymal component. A fibrous capsule separates these cells from the surrounding tissues. It generally presents as a slowly progressing painless swelling, which is well-delineated, nonsymptomatic, and not involving the facial nerve. Salivary gland tumors can be accurately diagnosed before surgery using fine-needle aspiration (FNA), ultrasonography (USG), and computed tomography (CT) scan. Calponin, cluster of differentiation 9 (CD9), glial fibrillary acidic protein (GFAP), Mcl-2, metastasis suppressor gene (NM23), p63, S-100, smooth muscle actin (SMA), and SRY-box transcription factor 10 (SOX10) exhibit the majority of the positive reactions in pleomorphic adenomas. The diagnostic marker pleomorphic adenoma gene 1 (PLAG1) is frequently employed since it is specific for pleomorphic adenoma. Although benign, these epithelial tumors have a propensity to recur and undergo malignant transformation if incompletely excised, leading to increased morbidity in these patients. A review of the consensus guidelines and literature was conducted, and the online literature on the subject from 2002 was included. This article is not a complete review of all the available literature; rather, it is a comprehensive review of the topic.

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Pleomorphic adenoma of nasal septum, an unusual site: a case report from Nepal

Cited by 2 publications

References 10 publications

A classic triphasic pleomorphic adenoma of nasal cavity mimicking as malignancy: a rare case report

A classic triphasic pleomorphic adenoma of nasal cavity mimicking as malignancy: a rare case report

A Review of the Current Literature on Pleomorphic Adenoma

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