Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Hikosaka, Keisuke; Kim, Juewon; Kajita, Masashi; Kanayama, Atsuhiro; Miyamoto, Yusei

doi:10.1016/j.colsurfb.2008.06.008

Cited by 83 publications

(58 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bimetallic nanoparticles consisting of gold and platinum are effective in quenching reactive oxygen species (ROS), including hydrogen peroxide (H 2 O 2 ) and the superoxide anion radical (O 2 À ), in a dose-dependent manner, 4) and gold nanoparticles enhance the antioxidant activity of vitamin E. 5) In addition nanoparticles of gold and platinum have been found to catalyze oxidation of NADH to NAD. 6,7) ROS have been implicated in bone metabolism. Osteoclasts (OC) express NADPH oxidase, a ROSgenerating enzyme, 8) and a key differentiation signal generated by the receptor activator of nuclear factor-B ligand (RANKL)/RANK interaction generates ROS in OC cells.…”

Section: Gold Nanoparticles Inhibited the Receptor Activator Of Nuclementioning

confidence: 99%

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Sul¹,

Kim²,

Kyung³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

105

View full text Add to dashboard Cite

Section: Gold Nanoparticles Inhibited the Receptor Activator Of Nuclementioning

confidence: 99%

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Sul¹,

Kim²,

Kyung³

et al. 2010

Bioscience, Biotechnology, and Biochemistry

105

View full text Add to dashboard Cite

“…The nano-Pt were a gift from Apt Co., Ltd. (Tokyo) and prepared by the citrate reduction of H 2 PtCl 6 (21). The average diameter of the nano-Pt was 2.0 nm, and the nano-Pt were dissolved in a large quantity of a citric acid solution.…”

Section: Preparation Of the Nano-ptmentioning

confidence: 99%

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

et al. 2011

View full text Add to dashboard Cite

Abstract.Recent research has shown that platinum nanoparticles (nano-Pt) efficiently quench reactive oxygen species (ROS) as a reducing catalyst. ROS have been suggested to regulate receptor activator of NF-κB ligand (RANKL)-stimulated osteoclast differentiation. In the present study, we examined the direct effects of platinum nano-Pt on RANKL-induced osteoclast differentiation of murine pre-osteoclastic RAW 264.7 cells. The effect of the nano-Pt on the number of osteoclasts was measured and their effect on the mRNA expression for osteoclast differentiation was assayed using real-time PCR. Nano-Pt appeared to have a ROS-scavenging activity. Nano-Pt decreased the number of osteoclasts (2+ nuclei) and large osteoclasts (8+ nuclei) in a dose-dependent manner without affecting cell viability. In addition, this agent significantly blocked RANKL-induced mRNA expression of osteoclastic differentiation genes such as c-fms, NFATc1, NFATc2, and DC-STAMP as well as that of osteoclast-specific marker genes including MMP-9, Cath-K, CLC7, ATP6i, CTR, and TRAP. Although nano-Pt attenuated expression of the ROS-producing NOXfamily oxidases, Nox1 and Nox4, they up-regulated expression of Nox2, the major Nox enzyme in macrophages. These findings suggest that the nano-Pt inhibit RANKL-stimulated osteoclast differentiation via their ROS scavenging property. The use of nano-Pt as scavengers of ROS that is generated by RANKL may be a novel and innovative therapy for bone diseases.

show abstract

“…This property is associated with the inhibition of DNA replication and mitosis by the addition of nano-Pt to DNA strand. 12 On the other side, research of Hikosaka et al 13 has revealed that nano-Pt have a nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase-like activity. This finding suggests that nano-Pt can be used as a remedy for oxidative stress diseases with suppressed mitochondrial complex I.…”

mentioning

confidence: 99%

Visualization of gold and platinum nanoparticles interacting with Salmonella Enteritidis and Listeria monocytogenes

Sawosz

Chwalibog

Szeliga³

et al. 2010

IJN

View full text Add to dashboard Cite

Purpose: Rapid development of nanotechnology has recently brought significant attention to the extraordinary biological features of nanomaterials. The objective of the present investigation was to evaluate morphological characteristics of the assembles of gold and platinum nanoparticles (nano-Au and nano-Pt respectively), with Salmonella Enteritidis (Gram-negative) and Listeria monocytogenes (Gram-positive), to reveal possibilities of constructing bacteria-nanoparticle vehicles. Methods: Hydrocolloids of nano-Au or nano-Pt were added to two bacteria suspensions in the following order: nano-Au + Salmonella Enteritidis; nano-Au + Listeria monocytogenes; nano-Pt + Salmonella Enteritidis; nano-Pt + Listeria monocytogenes. Samples were inspected by transmission electron microscope. Results: Visualization of morphological interaction between nano-Au and Salmonella Enteritidis and Listeria monocytogenes, showed that nano-Au were aggregated within flagella or biofilm network and did not penetrate the bacterial cell. The analysis of morphological effects of interaction of nano-Pt with bacteria revealed that nano-Pt entered cells of Listeria monocytogenes and were removed from the cells. In the case of Salmonella Enteritidis, nano-Pt were seen inside bacteria cells, probably bound to DNA and partly left bacterial cells. After washing and centrifugation, some of the nano-Pt-DNA complexes were observed within Salmonella Enteritidis. Conclusion:The results indicate that the bacteria could be used as a vehicle to deliver nano-Pt to specific points in the body.

show abstract

Platinum nanoparticles have an activity similar to mitochondrial NADH:ubiquinone oxidoreductase

Cited by 83 publications

References 55 publications

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant

Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells

Visualization of gold and platinum nanoparticles interacting with Salmonella Enteritidis and Listeria monocytogenes

Contact Info

Product

Resources

About