Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis

Filardo, Giuseppe; Kon, Elizaveta; Buda, Roberto; Timoncini, Antonio; Martino, Alessandro Di; Cenacchi, Annarita; Fornasari, Pier Maria; Giannini, Sandro; Marcacci, Maurilio

doi:10.1007/s00167-010-1238-6

Cited by 391 publications

(367 citation statements)

References 29 publications

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“…The intra-articular injection of MSCs, autologous PL and dexamethasone in a human patient with osteoarthritis of the knee resulted in a significant decrease in cartilage defect size (Centeno et al 2008). Furthermore, in human patients with knee osteoarthritis, the use of intra-articular injections of various platelet-rich preparations as sources of growth factors resulted in significant clinical improvement and pain reduction up to 6 or 12 months post-treatment (Kon et al 2010;Filardo et al 2011). Similar results were reported when such treatment was compared with hyalunoral (S anchez et al 2008) or normal saline injections (Patel et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Tyrnenopoulou

Diakakis

Karayannopoulou

et al. 2016

Veterinary Quarterly

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Background: Regenerative medicine has become one of the most promising therapies of equine osteoarthritis. Platelet lysate (PL) is rich in bioactive proteins and growth factors that play a crucial role in tissue healing. Objective: To evaluate the efficacy of intra-articularly injected autologous PL in equine athletes with naturally occurring osteoarthritis. Animals and methods: Fifteen warmblood geldings aged 8À19 years with osteoarthritis of the distal interphalangeal joint were included in this study. They were randomly divided into two groups; 10 horses received intra-articular injections of PL and 5 of normal saline (controls). Before treatment, platelet-derived growth factor (PDGF) levels in basal plasma and prepared PL were estimated. Each joint was injected twice within a three-week period. Lameness was evaluated using the American Association of Equine Practitioners grading system, before treatment and 10 days after each intra-articular injection. Horses were examined fortnightly for one year. Radiographic examination was performed six months post-treatment. The generalized estimating equation test was used for statistical analysis. Results: Acceptable levels of PDGF were detected in PLs (mean § SD: 258.0 § 52.3 pg/ml). The majority of horses (9/10) responded positively to PL treatment presenting lower lameness grades (p < 0.0005) compared to controls 10 days after the second injection, and returned to normal athletic activity. Radiographs revealed no changes in osteoarthritis lesions six months after treatment. One year post-injections, however, all horses relapsed to their initial degree of lameness. Conclusion: Intra-articularly injected autologous PL is an efficient method for temporarily managing osteoarthritis of the distal interphalangeal joint in athletic horses.

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Section: Discussionmentioning

confidence: 99%

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Tyrnenopoulou

Diakakis

Karayannopoulou

et al. 2016

Veterinary Quarterly

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“…There is an increased use of platelet related products for the treatment of knee OA in human beings (Kon et al 2009, Filardo et al 2011. Platelet concentrates have also been used for the treatment of OA and OC in horses (Carmona et al 2009).…”

Section: Resultsmentioning

confidence: 99%

“…APC have been widely used in human and veterinary procedures. Recent results have shown that APC can be used safely to treat OA in horses (Carmona et al 2009) and human beings (Kon et al 2009, Filardo et al 2011. Further, recently was described the use of autologous conditioned plasma (a kind of PRP)…”

Section: Introductionmentioning

confidence: 99%

Use of intra-articular autologous platelet concentrates as coadjutants in the surgical arthroscopy treatment of elbow dysplasia in a bitch

2013

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“…16 Filardo et al reported that 3 injections of intra-articular PRP in 90 patients with chronic knee degenerative conditions revealed improvement in International Knee Documentation Committee (IKDC) and EQ-VAS scores at the 2-year follow-up and that it had discernible positive effects especially on younger patients with early osteoarthritis. 17 However which growth factors are more beneficial needs better understanding. Since there is a lack of research evidence on treatment and efficacy of PRP injection, preparation methods, site of injection, and dose for clinical efficacy needs to be determined.…”

Section: Discussionmentioning

confidence: 99%

To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

et al. 2017

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Background: Platelet rich plasma (PRP) is a concentrate extract of platelets from autologous blood. It is known to increase growth factor of plasma and helps to heal the injured tissue. Platelet-rich plasma (PRP) is an autologous biologic treatment including patients own plasma, containing growth factors released from platelets. The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by an increase release of platelet-derived factors directly at the site of treatment. This study is done to assess the effects of platelet rich plasma application on pain in osteoarthritis knee.Methods: Total of 40 cases was included in this study (18 male and 22 females) with mean age of 57.3 (Range 35-75). All patients received intra-articular PRP injection. This study was conducted on the patients coming to orthopaedic department at MGM medical college and hospital, Navi Mumbai.Results: In this study it was found that there is decrease in pain on vas pain score, with increasing time. We followed up the patients for period of 3 months. We found that average mean VAS score was decreased from 6.0 to 4.13 after follow up of 3 months after a single dose of intra-articular PRP injection. Conclusions: PRP is an effective treatment for pain in OA knee. It is one of the new approaches in the field of orthopaedics to solve the issues of pain management.

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Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis

Cited by 391 publications

References 29 publications

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

Use of intra-articular autologous platelet concentrates as coadjutants in the surgical arthroscopy treatment of elbow dysplasia in a bitch

To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

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