Platelet-rich plasma

Marx, Robert E.; Carlson, Eric R.; Eichstaedt, Ralph M.; Schimmele, Steven R.; Strauß, J; Georgeff, Karen R.

doi:10.1016/s1079-2104(98)90029-4

Cited by 2,193 publications

(610 citation statements)

References 13 publications

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“…Platelets, platelet-rich plasma (PRP), platelet lysates, platelet-derived growth factor (PDGF), and supernatants from activated platelets all have well-known stimulatory effects on mesenchymal cells in vitro (4-10) and in vivo (11). The clinical potential of platelet constituents is interesting and several clinical trials and observations on wound healing and bone formation have been published (12)(13)(14)(15)(16)(17)(18). Previously, it has also been described that mineralization and bone repair is pH dependent.…”

Section: Introductionmentioning

confidence: 99%

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

et al. 2007

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Interestingly, we also found BMP-2 in platelet lysate. However BMP-2 was only present in LPB pH 4.0. We suggest, based on these experimental findings, that acidic milieu influence platelets to release growth factors more potent to stimulate osteoblast proliferation than neutral and alkaline platelet preparations. Lysed platelet concentrates prepared at an alkaline pH might release additional components with stimulating effects pH of platelet concentrate and growth stimulation 4 resulting in other features than cell proliferation. This is the first report, to our knowledge, about the presence of BMP-2 in platelet lysate and about a pH dependent stimulatory effect of lysed platelet concentrates on human osteoblast-like cell proliferation. Lysed platelet concentrates, preincubated in acidic or alkaline buffers, may benefit fracture healing, implant fixation and might also be advantageous in the treatment of wounds with platelet constituents; however, this has to be investigated in extended experimental and clinical settings.pH of platelet concentrate and growth stimulation 5

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Section: Introductionmentioning

confidence: 99%

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

et al. 2007

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“…Successful clinical applications have been reported using platelet-rich plasma, such as periodontal [34] and oral surgery [35], cosmetic surgery [36], spinal fusion [37], cardiac bypass surgery [38], and treatment of soft tissue ulcers [39].…”

Section: Discussionmentioning

confidence: 99%

“…More than 5000 studies documented the benefits and safety of PRP in enhancement of bone regeneration [12], wound healing [13], tendon and cartilage healing [14], corneal healing [15], and skin rejuvenation [16]. PRP is thus used more and more often in the plastic, reconstructive and aesthetic surgery fields [17]- [19].…”

Section: Introductionmentioning

confidence: 99%

Initial Experience of Face Augmentation Using Fat Graft-Platlet Rich Plasma Mix

Tolba¹,

Nasr²

2015

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Plastic surgeons accustomed to use autologous fat grafs for augmentation of soft tissues in the last two decades. The main drawback of fat grafting is unpredictable graft resorption. Several studies have searched for new ways of increasing the viability of the transplanted tissue to overcome this disadvantage. The most recent and promising approach is to mix the fat graft with Platelet-Rich Plasma (PRP) before transplantation. The purpose of this article is to present the initial experience using the autologous fat injection with platlet rich plasma as a method for fascial augmentation.

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“…Autogenous bone graft is the most preferred graft although its donor site morbidity. To reduce donor site morbidity related to autogenous bone graft and enhance bone regeneration with reducing post operative resorbtion, growth factors such as bone morphogenic proteins (BMPs) and platelet derived growth factors (PDGF) in combination with different kinds of bone substitutes were examined [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Platelet-Rich Fibrin on The Regeneration Capacity of Bone Marrow Aspirate In Alveolar Cleft Grafting (Clinical and Radiographic Study)

Al-Ashmawy¹,

Ali²,

Baiomy³

2017

Dentistry

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The present study aimed to evaluate the enhancing effect of platelet-rich fibrin (PRF) on autogenous bone marrow aspirate (BMA) using in a resorbable matrix for repair of alveolar cleft defects. It was conducted on 12 patients (7 males and 5 females) with unilateral alveolar cleft and oronasal leakage. They divided into two random equal groups (group I and II). In group I, alveolar cleft defect packed with a mixture of PRF, β-Tricalcium phosphate, and BMA, and the same mixture without PRF for group II. Our clinical results revealed that, all patients had uneventful wound healing except some cases in group II. While, densitometric analysis showed a high statistical significant difference between two groups (p=0.011737) at 6 months interval but, at 12 months interval difference was not statistically significant (p=0.142480). Also, volumetric measurements of new bone showed that, there was highly statistical significant difference (p=0.037997) between group I and II at 12 month interval. The present study concluded that PRF may enhance the regeneration capacity of the stem cells when it added to BMA. Thereby, they may accelerate bone regeneration in alveolar cleft defects. Moreover, it may be used as membrane to cover grafted alveolar defect.

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Platelet-rich plasma

Cited by 2,193 publications

References 13 publications

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

Variation of pH in lysed platelet concentrates influence proliferation and alkaline phosphatase activity in human osteoblast-like cells

Initial Experience of Face Augmentation Using Fat Graft-Platlet Rich Plasma Mix

Effect of Platelet-Rich Fibrin on The Regeneration Capacity of Bone Marrow Aspirate In Alveolar Cleft Grafting (Clinical and Radiographic Study)

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