Platelet‐rich fibrin membranes as scaffolds for periosteal tissue engineering

Abstract

PRF appears to be superior to collagen (Bio-Gide) as a scaffold for human periosteal cell proliferation. PRF membranes are suitable for in vitro cultivation of periosteal cells for bone tissue engineering.

Platelet-Rich Fibrin as a New Approach in Treating Gingival Recession: Systematic Review and Meta-Analysis

“…Also, the present Meta-Analysis found that CAF + PRF did not increase %RC when compared to CAF alone (p = 0.60). In regards to healing and pain assessment, all the three studies that included HI and pain in their outcomes consistently reported a significant reduction in pain for the first 5-7 days and faster healing in the PRF intervention when compared to the use of CTG or EMD, which was consistent with numerous studies describing faster healing potential of growth factors in regenerative procedures [32,38,39,[47][48][49][50][51][52]. This finding is explained by PRF characteristics, when compared to other forms of blood derived growth factors like PRP, in the slow release of growth factors over a period of 10 days which is the time needed for revascularization and CT formation in a soft tissue regeneration procedure, while PRP was known for an earlier release of growth factors in the healing cascade [53][54][55].…”

Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

“…Moreover, the phagocytosis of neutrophils and the enzymatic degradation process are modulated by FDP [8] and hence fibrin also plays an important role in immunity control. Studies have shown that PRF appears to be superior to collagen as a scaffold for human periosteal cell proliferation [9] and, rapid healing of the wound is observed without pain, dryness or purulent complications [7].…”

Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration

“…Various pathological etiologies result in dysfunction of the oral tissues and creation of bony defects, thus affecting the quality of life in these patients. The pivotal goal in periodontal and maxillofacial tissue regeneration is to reconstruct these defects which led to the search of a biofuel [1]. Focus has constantly been on devising a "wonder material" that is most effective in its regenerative potential.…”