Platelet Monoamine Oxidase in Women with Premenstrual Syndrome

Feine, Ruth; Belmaker, Robert H.; Rimón, Ranan; Ebstein, Richard P.

doi:10.1159/000117594

Cited by 9 publications

(4 citation statements)

References 10 publications

(26 reference statements)

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“…Neither did we find any variation in the activity in PMS patients, who were examined at the two times during the cycle most likely to result in a difference (preovulatorily and premenstrually) according to previous reports (15J6). The lack of variations in the present study, on the other hand, is in agreement with other previous reports, both with respect to controls (18) and PMS patients (19).…”

Section: Discussionsupporting

confidence: 94%

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Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Hallman

Oreland

Edman

et al. 1987

Acta Psychiatr Scand

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Women with premenstrual syndrome (PMS) of such severity that they actively had sought medical attention for their symptoms were compared with healthy female students with regard to platelet MAO activity and temperamental correlates by means of the Karolinska Scales of Personality (KSP), scales from the Eysenck Personality Questionnaire (EPQ) and Eysenck's IVE inventory. The women with PMS were divided into two groups; irritability and depression as predominating symptom. No variation in platelet MAO was found during the menstrual cycle, either in patients or in controls. Both PMS groups had significantly lower platelet MAO activity than the controls. There was no difference between the two groups with PMS. Also with regard to personality traits there were considerable differences between the females with PMS and the controls. There were few differences between the two groups of PMS patients. Thus, the patients scored significantly higher as regards somatic anxiety, muscular tension, indirect aggression, verbal aggression and neuroticism and lower as regards socialization than the controls.

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Section: Discussionsupporting

confidence: 94%

“…To our knowledge there is only one study on platelet M A 0 in relation to PMS. Thus, Feine et al (19) found no significant variation in platelet M A 0 activity during thc menstrual cycle in women with PMS. No controls were, however, studied at the same time.…”

mentioning

confidence: 88%

Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Hallman

Oreland

Edman

et al. 1987

Acta Psychiatr Scand

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“…; Dbhler and Hancke, 1978). Further, hormonal influences on platelet M A 0 in women (Belmaker et al, 1974; Feine et al, 1977) and in adult rat brain M A 0 (Zolovick et al, 1966; Kamberi and Kobayashi, 1970; Holzbauer and Youdim, 1973; Kueng et al, 1976) during the sexual cycle have been shown. Finally, treatment of normal adult, pregnant, or newborn rats with sex hormones can affect brain M A 0 (Collins et al, 1970; Luine a n d McEwen, 1977;Breuer e t al., 1978;Franz e t al., 1978; Wilson et al, 1979).…”

Section: ;mentioning

confidence: 95%

Gonadal Influences on the Sexual Differentiation of Monoamine Oxidase Type A and B Activities in the Rat Brain

Vaccari¹,

Caviglia²,

Sparatore³

et al. 1982

Journal of Neurochemistry

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The sex-dependent differentiation of monoamine oxidase (MAO) in the hypothalamus of 60-day-old, Charles River rats was found to involve only type A (MAO-A), and not type B (MAO-B) enzyme. In vivo inhibition of type A by clorgyline, and type B by (--)deprenyl, however, tended to decrease the specific activity of both types of MAO to a smaller extent in the female than in the male hypothalamus. When masculinization was prevented by neonatal administration of estradiol (E) to males, hypothalamic MAO-A and MAO-B activities increased in both control and MAO-inhibited rats. Androgenization of females, however, had little effect on the MAO activity. Whereas the effects of neonatal estrogenization were attributable neither to a direct influence of E nor to a sexual difference in the peripheral clearance of the MAO-inhibitor used, single, high doses of steroids to adult, but not to newborn rats, did acutely affect the kinetics of MAO-A. The activity of MAO-A was also decreased by high concentrations of E or TS in vitro. The imprinting for patterns of hypothalamic MAO-A and MAO-B in the two sexes results, probably, from genetic predetermination. Neonatal changes in the homeostasis of gonadal hormones may result in type-MAO nonspecific effects in adulthood, whereas the short-term effects of high concentrations of steroids may be selective for the A form.

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“…Progesterone, on the other hand, is known to increase M A 0 activity in the rat hypothalamus (Holzbauer & Youdim, 1973). Platelet M A 0 also varies during the menstrual cycle (Belmaker, Murphy, Wuatt & Loriaux, 1974), however, not in women with PMS (Feine, Belmaker, Rimon & Ebstein, 1977). The turnover of serotonin and gamma amio butyric acid, and the activity of catecholamine-0-methyltransferase in the brain are all influenced by estradiol and progesterone (Breuer & Koster, 1974;Ladisich, 1977;Saad, 1970).…”

Section: Estradiol and Progesterone And The Cnsmentioning

confidence: 99%

Premenstrual syndrom

Bäckström

Bancroft

Bixo

et al. 1982

Scandinavian J Psychology

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Premenstrual syndrome is a condition with cyclical mood changes occurring in 30 % of the female population of fertile ages. The symptom development is very closely related to the luteal phase indicating the existence of one or more factors during the luteal phase that provoke mental symptoms in sensitive patients. This is further supported by the fact that hysterectomized women with no menstrual bleedings but with the ovarian hormone cycle continue to show cyclical mood changes without having the cycle phase. The nature of the symptom provocating factor is still unknown but the ovarian hormones progesterone and/or estradiol are suspected. This as certain women taking oral contraceptives and sequential postmenopausal estrogen‐progestagen treatment achieve mood changes. Psychological and personality factors are probably also involved, at least in the degree of the mood change and the type of mood experienced.

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Platelet Monoamine Oxidase in Women with Premenstrual Syndrome

Cited by 9 publications

References 10 publications

Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Gonadal Influences on the Sexual Differentiation of Monoamine Oxidase Type A and B Activities in the Rat Brain

Premenstrual syndrom

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