Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Hallman, Jarmila; Oreland, Lars; Edman, Gunnar; Schalling, Daisy

doi:10.1111/j.1600-0447.1987.tb02890.x

Cited by 95 publications

(36 citation statements)

References 28 publications

(30 reference statements)

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“…PCR reactions with subsequent estimations of allelic genotypes, and radiometric assay of catalytic trbc MAO activity with 14 C-␤-phenylethylamine as substrate were carried out as previously described. 54,63 Intron 2 genotypes for AP-2␤, KSP scores and trbc MAO activity were determined for all individuals. In the binge-eating patients, four patients (9%) were homozygous for the short AP-2␤ intron 2 allele, 13 patients (28%) were heterozygous, and 29 patients (63%) were homozygous for the long allele.…”

Section: Transcription Factor Ap-2␤ and Binge-eating Disordermentioning

confidence: 99%

Genetic mechanisms of behavior—don't forget about the transcription factors

et al. 2001

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Major changes in psychiatric phenotypes due to genetic factors are seldom the result of single gene polymorphisms, but more often the result of several genetic mechanisms. In this millennium article we discuss the notion that the expression of numerous candidate genes could be regulated by the same transcription factors, and that polymorphisms in transcription factor genes might explain some phenotypes. We describe recent results of studies on the biological marker thrombocyte monoamine oxidase (trbc MAO) and the transcription factor AP-2␤. Low levels of trbc MAO is associated with temperamental characteristics such as sensation seeking and impulsiveness, and the enzyme is genetically regulated by specific transcriptional mechanisms. Transcription factor AP-2␤ is important for the development of midbrain structures and AP-2␤ has several binding sites in the regulatory regions of genes encoding key proteins in the monoamine transmitter systems. We have recently shown AP-2␤ to be linked to personality, binge-eating disorder, treatment with antidepressant drugs, and also to trbc MAO. Regardless of whether transcriptions factors, such as AP-2␤, regulate the expression of eg, the number of monoamine neurons or a variety of candidate genes within the monoamine systems, or both, we would like to emphasize the role of transcription factors, besides polymorphisms in monoaminergic candidate genes, when explaining inter-individual differences in temperament and psychiatric vulnerability. Molecular Psychiatry (2001) 6, 503-510.

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Section: Transcription Factor Ap-2␤ and Binge-eating Disordermentioning

confidence: 99%

Genetic mechanisms of behavior—don't forget about the transcription factors

et al. 2001

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“…Thereafter, platelet concentrations of the plasma samples were estimated electronically and the plasma stored at -80°C. Catalytic activity of platelet MAO was analysed by a radiometric assay with 14 C-labelled 2-phenylethylamine (ß-PEA) as substrate, as previously described [24]. Briefly, 50 Ìl of sonicated plasma was added to 50 Ìl of 0.1 mM 14 C-ß-PEA (0.5 ÌCi/ml) in 0.1 M sodium phosphate buffer, pH 7.8.…”

Section: Personality Inventorymentioning

confidence: 99%

Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

et al. 2002

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Background: A Swedish male criminal population was grouped into personality disorder subgroups and investigated with regard to personality traits and platelet monoamine oxidase (MAO) activity. The main aim of the study was to examine the possibility of a risk factor combination by having low platelet MAO activity as well as belonging to a certain diagnostic DSM-IV axis I (drug abuse in the present series) and/or II subgroup. Methods: Personality disorders were grouped into clusters according to the cluster system used in DSM-IV axis II. The prisoners were grouped into five subgroups and each subject completed the Karolinska Scales of Personality self-report questionnaire. The comparison group for the personality data comprised 51 non-criminal males from a longitudinal Swedish project. Platelet MAO activity was assessed for the criminals as well as for a control group including 60 non-criminal healthy male Caucasians. For testing the existence of syndromes, a configuration frequency analysis (CFA) was used. Results: The results showed low scores on the socialisation and high scores on the sensation seeking-related traits impulsiveness and monotony avoidance, and the somatic anxiety-related muscular tension in the criminals with any DSM-IV mental disorder, however most markedly in cluster AB and cluster B subjects. In addition, cluster AB subjects had significantly lower platelet MAO activity than controls. Two significant ‘types’ were found among the criminals: one was characterised by low platelet MAO activity, cluster B personality diagnosis as well as drug abuse disorder diagnosis; and the other by a pattern of normal platelet MAO activity, no cluster B personality disorder and no drug abuse disorder diagnosis. Conclusion: The aggregation of certain risk factors in the same individual has been shown to contribute to the development of criminal behaviour.

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“…These authors, using the Eysenck Personality Inventory, found that the severity of perimenstrual mood symptoms was highly related with neuroticism [24], a personality trait reflecting a condition of ill-being and often related to the presence of a psychiatric disorder (in particular a depressive disorder), and a tendency to seek medical help for these problems [25]. The correlation between neuroticism and LLPD has also been reported by other authors [26, 27, 28, 29, 30], whereas some studies did not find any differences between women with LLPD and asymptomatic controls in terms of neuroticism [31, 32]. Moreover, while some studies, which attempted to evaluate the personality correlates of LLPD by using standardized assessment instruments, reported a low prevalence of comorbid Axis II personality disorders in women with this condition [28, 33, 34], others found that passive-aggressive, borderline-cycloid, hypomanic traits were higher in LLPD women as compared to matched controls [35].…”

Section: Introductionmentioning

confidence: 62%

Personality Disorders and Depressive Symptoms in Late Luteal Phase Dysphoric Disorder

Ronchi¹,

Muro²,

Marziani³

et al. 1999

Psychother Psychosom

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Background: Although many significant studies of late luteal phase dysphoric disorder (LLPD) have been carried out, some conflicting findings on the relationships between personality disorders, depressive symptoms, hostility and LLPD deserve further investigation. Methods: Forty-three LLPD patients and 85 control subjects, evaluated by prospective daily ratings during two symptomatic cycles, received a detailed psychiatric evaluation, including the sections for psychotic, affective and anxiety disorders of the Structured Clinical Interview for DSM-III-R nonpatient version and the section for personality disorders; the Buss Durkee Inventory for Assessing Different Kinds of Hostility and the Montgomery-Åsberg Depression Rating Scale. Results: The odds of suffering from LLPD are about nine-fold (crude odds ratio, OR = 9.23, 95% confidence interval, CI 3.98–21.39) among women with mild or moderate depressive symptoms. When two age strata (below and above 30) are analyzed separately, the association between LLPD and depressive symptoms is strong and positive in both strata, while the association between LLPD and avoidant personality disorder is found only among older women (adjusted OR = 8.26, p < 0.05, 95% CI 1.03–66.35). Conclusions: The major finding from this preliminary study is the association between LLPD and depressive symptoms. Conversely, the association between LLPD and avoidant personality disorder remains controversial and seems to be dependent on age. Our findings support the hypothesis that LLPD and avoidant personality disorder may be considered as part of the spectrum of recurrent mood disorder rather than as qualitatively distinct nosological entities. Future studies are needed, adopting prospective, longitudinal assessments of personality prior to the onset of LLPD.

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Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Cited by 95 publications

References 28 publications

Genetic mechanisms of behavior—don't forget about the transcription factors

Genetic mechanisms of behavior—don't forget about the transcription factors

Personality Traits and Platelet Monoamine Oxidase Activity in a Swedish Male Criminal Population

Personality Disorders and Depressive Symptoms in Late Luteal Phase Dysphoric Disorder

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