Gonadal Influences on the Sexual Differentiation of Monoamine Oxidase Type A and B Activities in the Rat Brain

Vaccari, Andrea; Caviglia, Annamaria; Sparatore, Anna; Biassoni, Roberto

doi:10.1111/j.1471-4159.1982.tb12535.x

Cited by 10 publications

(1 citation statement)

References 30 publications

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“…Similarly, gonadectomy also increases MAO A activity in the PFC (Meyers et al, 2010), suggesting that acute treatment with androgens may enhance MAO activity, while chronic treatment exerts the opposite effect. In contrast to androgens, estrogen administration to neonatal, but not adult males elicits an increase in hypothalamic MAO activities (Vaccari et al, 1981). In females, estradiol reduces MAO A activity in the hypothalamus and amygdala (Luine et al, 1975; Ma et al, 1993; Gundlah et al, 2002).…”

Section: The Role Of Daergic Genes In G×s Interactions In Schizophreniamentioning

confidence: 99%

Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

Godar

Bortolato

2014

Front. Behav. Neurosci.

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Schizophrenia is a severe mental disorder, with a highly complex and heterogenous clinical presentation. Our current perspectives posit that the pathogenic mechanisms of this illness lie in complex arrays of gene × environment interactions. Furthermore, several findings indicate that males have a higher susceptibility for schizophrenia, with earlier age of onset and overall poorer clinical prognosis. Based on these premises, several authors have recently begun exploring the possibility that the greater schizophrenia vulnerability in males may reflect specific gene × sex (G×S) interactions. Our knowledge on such G×S interactions in schizophrenia is still rudimentary; nevertheless, the bulk of preclinical evidence suggests that the molecular mechanisms for such interactions are likely contributed by the neurobiological effects of sex steroids on dopamine (DA) neurotransmission. Accordingly, several recent studies suggest a gender-specific association of certain DAergic genes with schizophrenia. These G×S interactions have been particularly documented for catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), the main enzymes catalyzing DA metabolism. In the present review, we will outline the current evidence on the interactions of DA-related genes and sex-related factors, and discuss the potential molecular substrates that may mediate their cooperative actions in schizophrenia pathogenesis.

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Section: The Role Of Daergic Genes In G×s Interactions In Schizophreniamentioning

confidence: 99%

Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

Godar

Bortolato

2014

Front. Behav. Neurosci.

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Gonadal influences on the inhibition of monoamine oxidase type B activity

Vaccari

Biassoni

1982

J of Neuroscience Research

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Monoamine oxidase type B (MAO-B) was similarly active in the hypothalamus of 60-day-old male and female Charles River rats. A single, 2 mg/kg IP injection of deprenyl, however, resulted in a significantly greater inhibition of hypothalamic MAO-B in normal males than in normal females. Repeated administration of estrogen (estradiol valerate) to intact males postnatally, a treatment which disrupts the masculinization process, although not provoking true "feminization," decreased the inhibition of MAO-B, thus abolishing the sex-specific difference. The intensity of deprenyl-provoked hypothermia and ptosis in males exceeded that of females; neonatal and postnatal estrogenization of males resulted in diminution of these effects. Androgen administration to neonate females did little affect the biochemical and in vivo parameters of MAO inhibition. It is concluded that sex-specific, biochemical differences in MAO-B inhibition may have pharmacological correlates, and both facets of MAO inhibition are sensitive to neonatal exposure to estrogen.

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Constancy of adult hypothalamic tyrosine hydroxylase after gonadal steroid treatment during development

Vaccari

Biassoni

1982

J of Neuroscience Research

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Tyrosine hydroxylase (TH) was studied in the entire hypothalamus of 60-day-old male and female rats, and its activity was similar in both sexes. Administration of estrogen or androgen to male or female pups soon after birth and during development did not affect the kinetic parameters of TH. It is, thus, suggested that sexual dimorphism in the levels and turnover of catecholamines (CA) and their sensitivity to fluctuations in gonadal steroids during development do not depend on corresponding sex-related or steroid-sensitive differences in the synthesis of hypothalamic CA.

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Gonadal Influences on the Sexual Differentiation of Monoamine Oxidase Type A and B Activities in the Rat Brain

Cited by 10 publications

References 30 publications

Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission

Gonadal influences on the inhibition of monoamine oxidase type B activity

Constancy of adult hypothalamic tyrosine hydroxylase after gonadal steroid treatment during development

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