Gonadal influences on the inhibition of monoamine oxidase type B activity

Vaccari, Andrea; Biassoni, Roberto

doi:10.1002/jnr.490080104

Cited by 5 publications

(2 citation statements)

References 14 publications

(2 reference statements)

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“…Despite the known effects of gonadal steroids on aminergic metabolism [25][26][27], these results do not allow us to relate personality to monoaminergic activity throughout the action of gonadal steroids.…”

Section: Discussionmentioning

confidence: 74%

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Balada

Torrubia²,

Arqué³

1993

Neuropsychobiology

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The present study focused on exploring the relationship between a number of personality measures (Sensation Seeking Scale, SSS; State-Trait Anxiety Inventory, STAI; and Susceptibility to Punishment Scale, SP) and some parameters of the pituitary-gonadal axis (FSH, LH and 17β-estradiol). The study was carried out with a group of 37 female volunteers. The subjects were physically and mentally fit. None of them had a personal history of psychiatric or endocrine illness. All subjects were studied at the beginning of the follicular phase. The most relevant results showed an ‘inverted U shape’ relationship between sensation seeking and plasma FSH levels. Lower Thrill and Adventure Seeking (TAS) scores were also found in subjects with higher levels of 17β-estradiol.

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Section: Discussionmentioning

confidence: 74%

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Balada

Torrubia²,

Arqué³

1993

Neuropsychobiology

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“…Because in man both serotonin and dopamine are metabolized by MAO A and MAO B, the possibility that a change in MAO activity may change the relation between 5-HIAA and HV A in CSF should not be ignored. In this context, the well established influence of estradiol, testosterone, and progesterone on brain MAO A and MAO B activity (Luine et al 1975;Leung et al 1980;Chevillard et al 1981;Vaccari and Biassoni 1982;Luine and Rhodes 1983) is worth recalling; however, the physiological significance of this steroid influence on MAO activity still remains to be established. Moreover, animal experiments have revealed multiple examples of interactions between serotopin and dopamine not related to MAO activity (e.g.…”

Section: Influence Of Sex Steroids On the Hva To 5-hiaa Ratiomentioning

confidence: 99%

Cerebrospinal Fluid Levels of Monoamine Metabolites

Eriksson

Alling

Andersch

et al. 1994

Neuropsychopharmacol

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The cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), and the dopamine metabolite homovanillic acid (HVA) were measured in a group of drug-free non-depressed women with premenstrual syndrome (PMS) (late luteal phase dysphoric disorder) (n = 13) and in controls with no premenstrual complaints (n = 13). In six patients and eight controls, CSF samples from both the luteal and the follicular phase were obtained, whereas in the remainder of the subjects, samples from either the follicular phase (patients: 4, controls: 2) or the luteal phase (patients: 3, controls: 3) were taken. The following observations were made: (1) Neither in the follicular phase nor in the luteal phase did the mean concentrations of CSF monoamine metabolites in the PMS group differ from the corresponding values in the control group. (2) Neither in the PMS group nor in the control group did the mean concentrations of monoamine metabolites in CSF samples obtained in the luteal phase differ from the corresponding values obtained in the follicular phase. (3) The intraindividual, intersample variations of CSF HVA and 5-HIAA concentrations were significantly smaller in the PMS group than in the control group. (4) CSF HVA correlated strongly to CSF 5-HIAA in the luteal phase of both patients and controls whereas in the follicular phase, particularly in controls, this correlation was much weaker. (5) In the luteal phase, the CSF HVA/5-HIAA ratio correlated negatively to serum levels of estradiol, progesterone, and testosterone. (6) The CSF HVA/5-HIAA ratio was significantly lower in PMS patients than in controls. (7) A positive correlation between CSF MHPG and serum luteinizing hormone was observed in the follicular phase. (8) A positive correlation between CSF HVA and serum prolactin was observed in the luteal phase. Because the study was comprised of a small number of subjects, the reported findings until replicated should be interpreted with caution.

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Monoamine oxidase inhibition byl-deprenyl depends on both sex and route of administration in the rat

Murphy

Milgram

et al. 1993

Neurochem Res

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The monoamine oxidase B (MAO-B) inhibitor L-deprenyl, widely used to treat Parkinson's disease, has frequently been studied in animal models. We have examined the effects of several variables on activity levels of MAO-A and B in rat brain and liver following chronic (3 wks) treatment with L-deprenyl. Significant effects were observed for sex (females showed lower overall MAO-B activity in the liver), dose (MAO-A and B inhibition increased with dose, with females exhibiting greater sensitivity), route of administration (subcutaneous injection was more efficient than oral dosing), and dosing interval (MAO-B was significantly inhibited when dosing interval was increased to as long as 168 hours). Our results thus indicate that the effectiveness of L-deprenyl in vivo is dependent on several factors and that these must be taken into account in studies involving the benefits or risks of this drug.

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Gonadal influences on the inhibition of monoamine oxidase type B activity

Cited by 5 publications

References 14 publications

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Gonadal Hormone Correlates of Sensation Seeking and Anxiety in Healthy Human Females

Cerebrospinal Fluid Levels of Monoamine Metabolites

Monoamine oxidase inhibition byl-deprenyl depends on both sex and route of administration in the rat

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