Platelet indices- evaluation of their diagnostic role in pediatric thrombocytopenias (one year study)

Baig, Mirza Asif

doi:10.18203/2320-6012.ijrms20150618

Cited by 14 publications

(9 citation statements)

References 6 publications

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“…Moreover, our results showed significant increase in MPV in ITP children when compared to control group which is similar to data in the study done by Baig 2015 [ 32 ] who found significant increase in MPV within ITP patients and recommended the use of platelet indices as a diagnostic tool to differentiate ITP from acute leukemias.…”

Section: Discussionsupporting

confidence: 91%

IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

et al. 2021

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Background Immune thrombocytopenic purpura (ITP) is an acquired complex autoimmune thrombocytopenia. Uncontrolled cellular immune response is one of the key triggers for the loss of immune tolerance in ITP patients. The purpose of this study was to investigate the association of IL-23/Th17, IL-17A and IL-17A rs2275913 gene polymorphism with ITP in Egyptian children. Methods 60 patients with ITP and 50 healthy control children from Minia city- Egypt were involved. Serum levels of IL-23 and IL-17A were determined by enzyme-linked immunosorbent assay. The frequency of Th17 cells was measured using flow cytometer. Genotyping for IL-17A was performed via polymerase chain reaction-restriction fragment length polymorphism. Results Comparing children with ITP to controls, serum levels of IL-23 and IL-17A as well as Th17 cells percentage were significantly increased (p < 0.001). Also, higher levels of these ILs and Th17 cells percentage were associated with decreased platelet count within ITP patients (p < 0.001). Analysis of genotype frequencies for IL-17A rs2275913 polymorphism and its alleles (A, G) showed no significant difference between cases and controls. Likewise, no significant differences were demonstrated between acute and chronic ITP regarding both IL-17A rs2275913 polymorphism prevalence and levels of IL-23, IL-17A plus Th17 cells percentage. The frequency of A alleles was 85 and 86% within patients and controls, respectively. Conclusions Elevated levels of IL-23, IL-17A and Th17 cells may be involved in ITP pathogenesis while IL-17A polymorphism rs2275913 is not prevalent in Egyptian children with ITP.

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Section: Discussionsupporting

confidence: 91%

IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

et al. 2021

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“…Thrombocytopenia is defined as platelet count below 150,000/mm 3 . It is a frequent complication in patients admitted in an emergency care, 21 hence its early detection is important for proper management of the patients. Hence, the methods to distinguish between the types of thrombocytopenia like hypoproductive due to reduced production and hyperdestructive thrombocytopenia is necessary.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Platelet Indices and Its Predictive Value in Diagnosis of Thrombocytopenia

K¹,

Heena²,

Lavanya³

2018

jemds

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BACKGROUND Thrombocytopenia can be due to decreased production of platelets in bone marrow or due to increased destruction. Aetiology of thrombocytopenia can be evaluated by determination of platelet indices, whether it is hypoproductive or hyperdestructive type. Platelet indices (MPV, PDW, P-LCR, Platelet-Crit) are simple, cost-effective, non-invasive and reliable tool to differentiate types of thrombocytopenias. The main objective of the study was to evaluate the variation and relationship of platelet indices in hypoproductive and hyperdestructive thrombocytopenia cases. MATERIALS AND METHODS Automated Haematology Analyzer Sysmex XN-1000i is used to assess platelet indices. 70 cases of thrombocytopenia were included in our study. Inclusion and exclusion criteria applied. RESULTS This study includes 70 patients of thrombocytopenia over a period of 2 months, who were classified into hypoproductive (32 cases) and hyperdestructive (38 cases). The mean platelet count in hypoproduction group was (56.5 ± 18.5) x 103/mm and mean platelet indices were MPV= (10.6 ± 0.12) fL, PDW= (10.6 ± 0.13) fL, P-LCR= (28.93 ± 1.3) % and Platelet-Crit (0.05 ± 0.02). The mean platelet count of hyperdestructive group (41.3 ± 15.3) x 103/mm, mean platelet indices MPV= (11.4 ± 0.89) fL, PDW= (12.2 ± 2.16) fL, P-LCR= (36.1 ± 5.3) % and Platelet-Crit (0.05 ± 0.01). CONCLUSION The combined interpretation of MPV, PDW and P-LCR by automated cell counters can be very useful parameters in differentiating thrombocytopenias due to various aetiologies. Platelet indices showed inverse relationship with platelet count as they are increased in hyperdestructive type and shows linear relationship in hypoproliferative type. Platelet-Crit is a less sensitive parameter to differentiate these thrombocytopenias.

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“…Age range between 18 to 38 years, Gestational age (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) weeks, BMI (≥18-≤30) kg/m 2 and Recurrent pregnancy loss…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…[7] Mean platelet volume (MPV) , platelet crit (PCT), and platelet distribution width (PDW) were significantly higher in studies that investigated platelet parameters in cases with recurrent pregnancy loss. [7][8][9][10][11][12] . The aim of this study is To evaluate the change of platelet indices namely platelet count (PLC), platelet crit (PCT), platelet distribution width (PDW ) and mean platelet volume (MPV) among patients with recurrent pregnancy loss (RPL) and spontaneous abortion.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of platelet indices in cases of spontaneous abortion and recurrent pregnancy loss

Kassem

Elkhyat

El-Dakhakhni

et al. 2022

ijhs

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Background: Spontaneous abortion is defined as a clinically recognized pregnancy loss before the 20th week of gestation, or an expulsion of an embryo weighing 500 g or less. .Pregnancy is a condition of hypercoagulation. study aimed to evaluate the change of platelet indices namely platelet count, platelet crit , platelet distribution width and mean platelet volume among patients . Methods: This study is observational case control study . participants were 135 and divided into three groups Group1: 45 women with spontaneous abortion. Group2: 45 women with recurrent pregnancy loss.Group3: 45 normally pregnant women Results At cut off 14.12, platelet distribution width diagnose abortion (P=0.008) with sensitivity, specificity, PPV, NPV and accuracy of 74.4%, 53.3%, 76.1%, 51.1%, 67.4% respectively.At cut off 6.98, Mean platelet volume diagnose abortion (P=0.002) with sensitivity, specificity, PPV, NPV and accuracy of 76.7%, 44.4%, 75.0%, 57.1%, 70.4% respectively. At cut off 0.31, Platelet crit diagnose abortion with sensitivity, specificity, PPV, NPV and accuracy of 31.1%, 97.8%, 96.6%, 41.5%, 53.3% respectively. There were univariate regression for value of platelet indices in prediction of abortion in the studied sample. Conclusions: Platelet indices are markers for the prediction of spontaneous abortion and recurrent pregnancy loss

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Platelet indices- evaluation of their diagnostic role in pediatric thrombocytopenias (one year study)

Cited by 14 publications

References 6 publications

IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

IL-23/Th17 pathway and IL-17A gene polymorphism in Egyptian children with immune thrombocytopenic purpura

Analysis of Platelet Indices and Its Predictive Value in Diagnosis of Thrombocytopenia

Evaluation of platelet indices in cases of spontaneous abortion and recurrent pregnancy loss

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